00:00:00
the one I wanted to do is that new macro
00:00:03
study on gp1s which I think is super
00:00:05
interesting oh tell us do you guys
00:00:07
remember I talked a while ago about how
00:00:09
they were able to mine VA data so the VA
00:00:12
right they they take care of veterans
00:00:15
and they have all the medical records
00:00:17
and on an anonymized basis they can make
00:00:20
that data available to researchers and
00:00:22
so if you guys remember this this is how
00:00:23
they identified that the Epstein bar
00:00:25
virus or the virus that causes mono as
00:00:27
being statistically certain to be the
00:00:29
trigger for multiple sclerosis in the
00:00:31
cohort of hundreds of thousands of
00:00:33
patients that were in this this data set
00:00:36
no
00:00:38
one got Ms that didn't get Epstein bar
00:00:41
virus if you did not get Epstein bar
00:00:43
virus you did not get Ms I don't know if
00:00:45
you guys remember I did the science
00:00:46
Corner a while ago anyway so the data
00:00:48
set that you can mine at the VA is
00:00:49
incredible so they pulled all the data
00:00:51
from everyone that's been on the glp1
00:00:53
agonists and they identified all of the
00:00:55
health effects across multiple
00:00:57
indications the statistical difference
00:00:58
between the cohorts okay so this
00:01:00
research team out of St Louis pulled all
00:01:04
the data from the VA database and
00:01:06
basically they looked at you know 1.2
00:01:09
million people with diabetes that didn't
00:01:10
take anything compared to 215,000 that
00:01:14
took the glp1 receptor agonists and
00:01:17
another 600,000 people that took other
00:01:19
drugs for diabetes so basically this
00:01:23
cohort
00:01:25
segmentation allows them to isolate the
00:01:28
effect of the glp1 drugs um and as you
00:01:31
can see here this shows across hundreds
00:01:33
of thousands of patients the effect of
00:01:35
the glp1 on a hazard ratio which means
00:01:38
like How likely are you to have the
00:01:40
following health condition versus the
00:01:42
population that's not taking the glp
00:01:44
ones and then uh on the right if you
00:01:47
scroll to the right Nick are the
00:01:49
increase in risk and on the left are the
00:01:51
things that go down so the increase the
00:01:53
only thing that increased is like you
00:01:54
know 8% or 10% increase in nausea and
00:01:57
vomiting y confirm uh muscular skeletal
00:02:01
complications grd which is you know
00:02:03
gastric reflux from sleep indigestion
00:02:08
yeah and sleep disturbance to
00:02:10
indigestion so it's all abdominal stuff
00:02:12
now if you go over here to the benefit
00:02:14
side so the benefit side is what
00:02:16
conditions did you see a decrease in so
00:02:18
you have a decrease in shock a decrease
00:02:20
in uh he hepatic failure so liver
00:02:23
failure respiratory failure cardiac
00:02:26
arrest in fact on cardiac arrest you see
00:02:28
a 30% decrease in the probability of
00:02:31
having cardiac arrest from the cohort
00:02:33
that's on the gp1 verus Bia wow
00:02:38
schizophrenia so so this goes to the
00:02:40
point if you guys remember the interview
00:02:41
I did a couple months ago with the CEO
00:02:43
of Eli Lily that they have all these
00:02:46
clinical trials going on right now for
00:02:48
different indications for the glp1
00:02:50
receptor agonists that they're seeing
00:02:51
that there's health benefits Beyond just
00:02:54
the weight loss in reducing things like
00:02:56
kidney disease obviously liver problems
00:02:58
mental problems and so on do we know why
00:03:01
and and if we don't know why do you
00:03:04
think it's
00:03:05
because this is suppressing the food and
00:03:08
it's the the lack of food or the change
00:03:10
in the food consumption that's creating
00:03:12
this do you know what I'm asking like do
00:03:13
you think the drug is actually yeah yeah
00:03:15
so um you should watch the interview I
00:03:18
did with RX in fact this is a good
00:03:19
moment to call it out if you haven't
00:03:20
seen it yeah I think he highlights that
00:03:23
this class of drugs there are you know
00:03:25
genes get turned on and off so there's a
00:03:27
you know what's called a gene expression
00:03:30
Cascade that occurs with certain
00:03:33
compounds so we know that the gp1
00:03:35
receptor Agonist means that it binds to
00:03:37
these glp1 sites and there's a cascading
00:03:40
effect of genes that then get expressed
00:03:42
and what that seems to do is turn off
00:03:44
things like inflammatory markers it
00:03:46
turns on things like C two genes which
00:03:49
can actually increase cellular repair so
00:03:51
there seem to be other benefits from
00:03:53
these drugs Beyond just the appetite
00:03:54
control and it's not the appetite
00:03:56
control itself but there seems to be
00:03:58
other effects let me ask you a question
00:04:00
from these these receptors being
00:04:01
activated would you put your kids on
00:04:04
this no okay would you put your wife on
00:04:08
this I would consider it and I would
00:04:11
consider it for myself too just for the
00:04:12
anti-inflammatory effects how will you
00:04:15
make that decision well for me
00:04:17
personally and the thing that I weigh
00:04:18
against is the muscle loss and uh the
00:04:21
the bone density loss so I think that if
00:04:23
you look at the the biggest kind of
00:04:25
effect on these on a on the downside
00:04:26
basis is you should increase your
00:04:29
protein in your diet you have to do
00:04:30
weightlifting there's things that you
00:04:32
would do and frankly if you do those
00:04:34
things anyway if you increase protein in
00:04:35
your diet and do more weightlifting
00:04:37
you're actually going to see very good
00:04:39
health benefits from just doing those
00:04:40
things that may actually outweigh the
00:04:42
benefits you get from on the G I have a
00:04:44
question D which is and this is the
00:04:45
question is when when you look at that
00:04:47
data and you talk to the the
00:04:49
CEOs how much you think really longterm
00:04:51
when the longterm sites are out is going
00:04:53
to be that it was the drug or just that
00:04:55
being obese is very bad for you and so
00:04:58
when you take your body fat down
00:04:59
dramatically all these other Gene
00:05:01
Expressions happen anyway right so you
00:05:03
think it which one will it be well this
00:05:04
is this is what they're starting to
00:05:05
isolate and I will say Antonio they are
00:05:07
starting to see that there are other
00:05:10
Expressions that are not related to the
00:05:12
Obesity and people that don't have
00:05:13
obesity that they're using that are
00:05:15
using these drugs so they're they're
00:05:16
seeing that cohort data now clinical
00:05:18
studies uh phase two were published and
00:05:20
I think we're going to see phase three
00:05:22
and some of these indications soon but
00:05:24
it is looking very positive that it's
00:05:26
not just the loss of obesity now to your
00:05:28
point being obese
00:05:30
not exercising eating poorly destroys
00:05:33
your health you stop that right right
00:05:35
everything gets better um if you lift
00:05:37
weight freeer can you tell us when you
00:05:39
decide to do this I will yeah if I if I
00:05:41
do do a glp1 um receptor Agonist I will
00:05:44
let you guys know right now I'm I I
00:05:46
actually feel like I want to go through
00:05:48
a process of
00:05:50
increasing uh my weightlifting routine
00:05:52
more I I you know I've been trying to
00:05:54
create a more kind of rigorous my
00:05:56
schedule just sucks so that's been the
00:05:57
hardest thing for me but I actually want
00:05:58
to go through that first before making
00:06:00
that
00:06:01
decision kind of cool David I'm sorry no
00:06:04
I was just curious why why that order I
00:06:06
don't understand I want to measure the
00:06:07
effects because I do think that if you
00:06:09
actually get into a regular
00:06:10
weightlifting routine and you increase
00:06:13
protein in your diet which is another
00:06:14
thing I've been making a a concerted
00:06:16
measured effort to do which is hard as a
00:06:19
vegetarian by the
00:06:21
way you see pretty significant uh health
00:06:24
effects and so I'm trying to get through
00:06:25
the process of increasing muscle
00:06:27
composition before I make the de ision
00:06:29
on whether or not to add G one I don't
00:06:31
want to kind of confound the two factors
00:06:32
you know what I did that made it super
00:06:34
easy for me um is I got uh egg whites in
00:06:37
a carton and I have and I have this
00:06:40
incredible uh
00:06:42
crunchy spicy garlic thing that
00:06:45
everybody muku and everybody makes and
00:06:47
everybody's crazy about just in the
00:06:49
mornings I'll eat whatever it is 10
00:06:51
ounces 12 ounces of egg whites with that
00:06:54
spicy stuff it's delicious it's awesome
00:06:56
and I just try to you know get that
00:06:59
whatever 30 40 grams of protein first
00:07:01
thing in the morning and then doing the
00:07:03
rucking well this is is easy like you
00:07:05
just wear a 35 lb weight vest freeberg
00:07:08
and you walk a mile or two and you will
00:07:10
get like my problem Jason with all of
00:07:13
this is that every time I see something
00:07:15
so I saw Gary Brea on the Shawn Ryan
00:07:17
podcast recently and Shan Ryan asks him
00:07:21
like what are a handful of things that
00:07:23
you recommend for everybody right and he
00:07:26
recommends mineral salt and then he
00:07:27
recommends a methylated vitamin
00:07:29
recommends amino acids whatever there's
00:07:31
a protocol then if you happen to catch a
00:07:33
clip on X of Andrew huberman he'll have
00:07:36
a protocol and then Brian Johnson has a
00:07:38
protocol and the problem is all these
00:07:40
Protocols are slightly the same but
00:07:43
they're just different enough where it
00:07:44
creates a huge cognitive load in a
00:07:46
normal person like myself to your point
00:07:48
freeberg Who's busy who's got a job
00:07:50
who's got kids how do you decide and so
00:07:54
I would really love something to be sort
00:07:57
of like I don't want to say gold
00:07:59
standard because you can't say that but
00:08:02
that is like what's the real bank for
00:08:03
your buck what Antonio said you know are
00:08:06
you just better off just losing the 50
00:08:07
pounds and then this is why these
00:08:10
products are successful and I think will
00:08:12
be continue to grow pretty dramatically
00:08:14
Antonio is because it is pop a pill and
00:08:17
it solves all those problems it doesn't
00:08:18
require a cognitive load it will be in a
00:08:20
pill format soon right I mean the pills
00:08:23
are almost here I would be very cool
00:08:25
actually DAV if you do this U to Jamal's
00:08:27
point about you know people being
00:08:29
confused if you did the every the every
00:08:32
person's um kind of story around this
00:08:35
journey and you documented it you know
00:08:37
like you you did like this is my weight
00:08:39
I did weightlifting first and I did the
00:08:40
gop1 and you actually did like a weekly
00:08:42
thing where you checked in and even it
00:08:44
was 10 minutes up on X or something
00:08:45
where you just gave people the journey
00:08:49
um in a way that wasn't so complicated
00:08:50
because I think people are confused Jam
00:08:52
me I have I have very good doctors you
00:08:53
guys get doctors but if you don't you
00:08:56
don't know what to do by the way that
00:08:57
the problem for me just to give you a
00:08:59
sense of it I had a doctor in La I had a
00:09:02
doctor in San Francisco I would have
00:09:04
them do their own versions of things
00:09:05
then I would have somebody else help me
00:09:08
compare it cost me way too much money
00:09:10
and all that complexity did was make the
00:09:13
quality of my healthare actually go down
00:09:15
yeah and instead what I really wanted
00:09:17
was just a very simple protocol that
00:09:19
said take the metformin because it's
00:09:21
good for you take the vitamin D take the
00:09:23
omega-3 fatty acids otherwise just eat
00:09:25
this meal plan and it would help me a
00:09:28
lot more than then I've had to Cobble it
00:09:30
together myself because by the way when
00:09:32
you see something like you know Gary
00:09:33
Brea is very very articulate very smart
00:09:36
but when I see him on the Shan Ryan
00:09:37
podcast the first thing I do is I go and
00:09:40
populate an Amazon cart with all the
00:09:41
things that he said because my instinct
00:09:44
is well I should do the right thing for
00:09:45
myself this is a couple hundred bucks
00:09:47
it's worth the investment but then the
00:09:49
day after somebody else say something
00:09:52
else you know so I'll be really you have
00:09:54
a little OCD though jamad I've known you
00:09:55
for a long time you get very obsessive
00:09:58
with died because of poor health my best
00:10:01
friend died of poor health I feel like
00:10:04
you you should at least do the things
00:10:06
that are preventable have you guys seen
00:10:08
that that post jamat did with he was
00:10:09
like half naked in the mirror he looks
00:10:11
great what are you talking about he
00:10:13
looks great if if you you could look
00:10:15
like that you you'd do it too no no no
00:10:17
I'm talking about like when you had the
00:10:18
glucose monitor I'm sitting with him at
00:10:20
the poker table he's got the glucose
00:10:22
monitor and he's taking a sip of wine
00:10:24
he's checking the glucose he's he's
00:10:26
having like a piece of BJ then he's
00:10:28
checking the glucose
00:10:30
it just like literally becomes obsessive
00:10:32
then with the you know then we had
00:10:35
a i me come on that's this AI stuff this
00:10:38
Genera you know what's so funny about
00:10:40
this picture all these clowns all these
00:10:42
clowns on the internet are like they
00:10:44
don't understand that when you're 6'2
00:10:47
these are big legs when you're six not
00:10:51
big when you're short King when you're
00:10:55
short King when you're like my Chopstick
00:10:57
I lost my chopsticks when you're 57 58 I
00:11:01
get I get it while you guys cuz you guys
00:11:02
are all stubby and short I don't get it
00:11:04
this is the problem with generative AI
00:11:05
you can tell it's a fake photo you can
00:11:07
tell that that was generative AI because
00:11:09
nobody has legs that thin how could you
00:11:11
have biceps and then legs that th
00:11:14
doesn't make sense
00:11:16
blushing unbelievable what a thirst trap
00:11:19
now you guys are going to find photos of
00:11:21
Antonio and I we're going to throw them
00:11:22
unb listen I have have four pieces of
00:11:26
advice for people number one get good
00:11:28
sleep number two exercise number three
00:11:31
diet number four meditation and if you
00:11:33
want to do that it's very simple you get
00:11:35
you get the calm meditation app you get
00:11:37
the eight sleep sleep you get the fitbod
00:11:39
for fitness and then you get neutri
00:11:46
forut your diet those are the four
00:11:49
things you focus
00:11:50
on make sure you have a AA you get a
00:11:54
good Athena assistant all of this is
00:11:56
brought to you by my NGO which is all in
00:11:58
Ng USA gave us18 Million last year guys
00:12:01
I forgot to tell you about it but don't
00:12:04
worry it's in an offshore account for
00:12:05
all of us when we get back to Ethiopia
00:12:08
Vietnam we have an all-in castle built
00:12:10
there okay we built uh with our NGO
00:12:13
we'll see everybody next week love you
00:12:16
boys
