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the one I wanted to do is that new macro study on gp1s which I think is super interesting oh tell us do you guys
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remember I talked a while ago about how they were able to mine VA data so the VA
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right they they take care of veterans and they have all the medical records and on an anonymized basis they can make
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that data available to researchers and so if you guys remember this this is how they identified that the Epstein bar
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virus or the virus that causes mono as being statistically certain to be the trigger for multiple sclerosis in the
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cohort of hundreds of thousands of patients that were in this this data set no one got Ms that didn't get Epstein bar
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virus if you did not get Epstein bar virus you did not get Ms I don't know if you guys remember I did the science
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Corner a while ago anyway so the data set that you can mine at the VA is incredible so they pulled all the data
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from everyone that's been on the glp1 agonists and they identified all of the health effects across multiple
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indications the statistical difference between the cohorts okay so this research team out of St Louis pulled all
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the data from the VA database and basically they looked at you know 1.2 million people with diabetes that didn't
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take anything compared to 215,000 that took the glp1 receptor agonists and another 600,000 people that took other
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drugs for diabetes so basically this cohort segmentation allows them to isolate the
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effect of the glp1 drugs um and as you can see here this shows across hundreds of thousands of patients the effect of
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the glp1 on a hazard ratio which means like How likely are you to have the following health condition versus the
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population that's not taking the glp ones and then uh on the right if you scroll to the right Nick are the
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increase in risk and on the left are the things that go down so the increase the
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only thing that increased is like you know 8% or 10% increase in nausea and vomiting y confirm uh muscular skeletal
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complications grd which is you know gastric reflux from sleep indigestion yeah and sleep disturbance to
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indigestion so it's all abdominal stuff now if you go over here to the benefit side so the benefit side is what
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conditions did you see a decrease in so you have a decrease in shock a decrease in uh he hepatic failure so liver
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failure respiratory failure cardiac arrest in fact on cardiac arrest you see a 30% decrease in the probability of
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having cardiac arrest from the cohort that's on the gp1 verus Bia wow schizophrenia so so this goes to the
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point if you guys remember the interview I did a couple months ago with the CEO of Eli Lily that they have all these
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clinical trials going on right now for different indications for the glp1 receptor agonists that they're seeing
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that there's health benefits Beyond just the weight loss in reducing things like
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kidney disease obviously liver problems mental problems and so on do we know why
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and and if we don't know why do you think it's because this is suppressing the food and
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it's the the lack of food or the change in the food consumption that's creating this do you know what I'm asking like do
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you think the drug is actually yeah yeah so um you should watch the interview I did with RX in fact this is a good
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moment to call it out if you haven't seen it yeah I think he highlights that this class of drugs there are you know
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genes get turned on and off so there's a you know what's called a gene expression
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Cascade that occurs with certain compounds so we know that the gp1 receptor Agonist means that it binds to
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these glp1 sites and there's a cascading effect of genes that then get expressed
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and what that seems to do is turn off things like inflammatory markers it turns on things like C two genes which
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can actually increase cellular repair so there seem to be other benefits from these drugs Beyond just the appetite
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control and it's not the appetite control itself but there seems to be other effects let me ask you a question
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from these these receptors being activated would you put your kids on this no okay would you put your wife on
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this I would consider it and I would consider it for myself too just for the anti-inflammatory effects how will you
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make that decision well for me personally and the thing that I weigh against is the muscle loss and uh the
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the bone density loss so I think that if you look at the the biggest kind of effect on these on a on the downside
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basis is you should increase your protein in your diet you have to do weightlifting there's things that you
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would do and frankly if you do those things anyway if you increase protein in your diet and do more weightlifting
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you're actually going to see very good health benefits from just doing those things that may actually outweigh the
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benefits you get from on the G I have a question D which is and this is the question is when when you look at that
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data and you talk to the the CEOs how much you think really longterm when the longterm sites are out is going
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to be that it was the drug or just that being obese is very bad for you and so when you take your body fat down
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dramatically all these other Gene Expressions happen anyway right so you think it which one will it be well this
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is this is what they're starting to isolate and I will say Antonio they are starting to see that there are other
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Expressions that are not related to the Obesity and people that don't have obesity that they're using that are
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using these drugs so they're they're seeing that cohort data now clinical studies uh phase two were published and
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I think we're going to see phase three and some of these indications soon but it is looking very positive that it's
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not just the loss of obesity now to your point being obese not exercising eating poorly destroys
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your health you stop that right right everything gets better um if you lift weight freeer can you tell us when you
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decide to do this I will yeah if I if I do do a glp1 um receptor Agonist I will let you guys know right now I'm I I
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actually feel like I want to go through a process of increasing uh my weightlifting routine
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more I I you know I've been trying to create a more kind of rigorous my schedule just sucks so that's been the
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hardest thing for me but I actually want to go through that first before making that
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decision kind of cool David I'm sorry no I was just curious why why that order I
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don't understand I want to measure the effects because I do think that if you actually get into a regular
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weightlifting routine and you increase protein in your diet which is another thing I've been making a a concerted
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measured effort to do which is hard as a vegetarian by the way you see pretty significant uh health
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effects and so I'm trying to get through the process of increasing muscle composition before I make the de ision
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on whether or not to add G one I don't want to kind of confound the two factors you know what I did that made it super
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easy for me um is I got uh egg whites in a carton and I have and I have this incredible uh
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crunchy spicy garlic thing that everybody muku and everybody makes and everybody's crazy about just in the
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mornings I'll eat whatever it is 10 ounces 12 ounces of egg whites with that spicy stuff it's delicious it's awesome
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and I just try to you know get that whatever 30 40 grams of protein first thing in the morning and then doing the
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rucking well this is is easy like you just wear a 35 lb weight vest freeberg and you walk a mile or two and you will
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get like my problem Jason with all of this is that every time I see something so I saw Gary Brea on the Shawn Ryan
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podcast recently and Shan Ryan asks him like what are a handful of things that you recommend for everybody right and he
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recommends mineral salt and then he recommends a methylated vitamin recommends amino acids whatever there's
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a protocol then if you happen to catch a clip on X of Andrew huberman he'll have
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a protocol and then Brian Johnson has a protocol and the problem is all these Protocols are slightly the same but
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they're just different enough where it creates a huge cognitive load in a normal person like myself to your point
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freeberg Who's busy who's got a job who's got kids how do you decide and so I would really love something to be sort
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of like I don't want to say gold standard because you can't say that but that is like what's the real bank for
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your buck what Antonio said you know are you just better off just losing the 50 pounds and then this is why these
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products are successful and I think will be continue to grow pretty dramatically
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Antonio is because it is pop a pill and it solves all those problems it doesn't require a cognitive load it will be in a
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pill format soon right I mean the pills are almost here I would be very cool actually DAV if you do this U to Jamal's
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point about you know people being confused if you did the every the every person's um kind of story around this
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journey and you documented it you know like you you did like this is my weight I did weightlifting first and I did the
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gop1 and you actually did like a weekly thing where you checked in and even it was 10 minutes up on X or something
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where you just gave people the journey um in a way that wasn't so complicated because I think people are confused Jam
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me I have I have very good doctors you guys get doctors but if you don't you don't know what to do by the way that
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the problem for me just to give you a sense of it I had a doctor in La I had a doctor in San Francisco I would have
00:09:04
them do their own versions of things then I would have somebody else help me compare it cost me way too much money
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and all that complexity did was make the quality of my healthare actually go down
00:09:15
yeah and instead what I really wanted was just a very simple protocol that said take the metformin because it's
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good for you take the vitamin D take the omega-3 fatty acids otherwise just eat this meal plan and it would help me a
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lot more than then I've had to Cobble it together myself because by the way when
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you see something like you know Gary Brea is very very articulate very smart but when I see him on the Shan Ryan
00:09:37
podcast the first thing I do is I go and populate an Amazon cart with all the things that he said because my instinct
00:09:44
is well I should do the right thing for myself this is a couple hundred bucks it's worth the investment but then the
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day after somebody else say something else you know so I'll be really you have a little OCD though jamad I've known you
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for a long time you get very obsessive with died because of poor health my best friend died of poor health I feel like
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you you should at least do the things that are preventable have you guys seen that that post jamat did with he was
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like half naked in the mirror he looks great what are you talking about he looks great if if you you could look
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like that you you'd do it too no no no I'm talking about like when you had the glucose monitor I'm sitting with him at
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the poker table he's got the glucose monitor and he's taking a sip of wine he's checking the glucose he's he's
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having like a piece of BJ then he's checking the glucose it just like literally becomes obsessive
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then with the you know then we had a i me come on that's this AI stuff this Genera you know what's so funny about
00:10:40
this picture all these clowns all these clowns on the internet are like they don't understand that when you're 6'2
00:10:47
these are big legs when you're six not big when you're short King when you're short King when you're like my Chopstick
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I lost my chopsticks when you're 57 58 I get I get it while you guys cuz you guys
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are all stubby and short I don't get it this is the problem with generative AI you can tell it's a fake photo you can
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tell that that was generative AI because nobody has legs that thin how could you
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have biceps and then legs that th doesn't make sense blushing unbelievable what a thirst trap
00:11:19
now you guys are going to find photos of Antonio and I we're going to throw them
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unb listen I have have four pieces of advice for people number one get good sleep number two exercise number three
00:11:31
diet number four meditation and if you want to do that it's very simple you get you get the calm meditation app you get
00:11:37
the eight sleep sleep you get the fitbod for fitness and then you get neutri forut your diet those are the four
00:11:49
things you focus on make sure you have a AA you get a good Athena assistant all of this is
00:11:56
brought to you by my NGO which is all in Ng USA gave us18 Million last year guys
00:12:01
I forgot to tell you about it but don't worry it's in an offshore account for all of us when we get back to Ethiopia
00:12:08
Vietnam we have an all-in castle built there okay we built uh with our NGO we'll see everybody next week love you
00:12:16
boys