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CML is kind of the predominant molecule that that gets formed in this extracellular matrix that's driving
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aging and nothing breaks it down. So, these scientists set out to try and create an enzyme. An enzyme is a protein
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that breaks something down that can break down CML. And so, these guys kind of went out and they took the target,
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which is CML and tried to figure out, okay, how do we actually degrade CML, clear that extracellular matrix and
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reverse aging. They started to test it on the proteins that we would find in our body, casein, collagen, retinal
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proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97%
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of the CML. Just degrade it away. And then they they found several sites where they were able to degrade over 90%
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and then they took actual human skin from elderly patients that had donated their skin and they put this enzyme onto
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that skin and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to
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the age of a 31-year-old. This is from greater than 70-year-old patients just by putting this enzyme on the skin. And
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so, it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed
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evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins,
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do high-throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can
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do something pretty profound for human health. >> It will be a trillion-dollar market.
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>> [laughter] >> Yeah. You can create a cream >> if you could put this enzyme literally
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on your skin and have it absorbed in >> cream. >> Yeah. >> Game over. >> Unbelievable.
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>> That alone is $2 trillion.