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David Friedberg: Is This Pesticide Causing a Colon Cancer Spike in Young People?

April 28, 2026 / 02:27

This episode discusses the alarming rise in colon cancer among young people under 50, with a focus on the pesticide piclorum and its environmental impact. The conversation highlights that colon cancer rates have increased by over 80% in the last two decades among younger individuals, contrasting with the historical trend of the disease affecting older populations.

The hosts examine the persistence of piclorum in the environment, noting that it does not biodegrade easily and can contaminate groundwater. They emphasize that the last EPA safety study on piclorum was conducted in 1995, raising concerns about regulatory oversight.

Research findings are presented, showing a correlation between piclorum usage in various U.S. counties and increased colon cancer rates. The discussion suggests that long-term exposure to certain chemicals may alter the epigenome, potentially leading to cancer development.

The episode calls for more comprehensive research and government action to address the use of harmful chemicals in the food supply and environment, urging a reevaluation of industry practices.

TLDR

The episode highlights the rise of colon cancer in young people linked to the pesticide piclorum and calls for regulatory action.

Episode

2:27
00:00:00
There's been a scary rise in the number of young people, people generally under
00:00:04
50 years old that are getting colon cancer. That number has climbed by over 80%. In just the last two decades,
00:00:12
historically, it's been an age related disease. So, as you get older, over 70
00:00:15
years old, your probability of getting colon cancer shoots through the roof. But this rise in young people getting
00:00:20
colon cancer has been pretty alarming. And there's been a real question mark on
00:00:24
what is causing it. This is the difference between people that got colon cancer that were over 70. when you
00:00:29
typically have a very high chance of getting it and people that are under 50 when you don't. And what is going on
00:00:35
with people under 50? And you can see there's this one row here that's all
00:00:40
orange. That row is a pesticide called piclorum. And piclorum became a very widely used herbicide in our
00:00:49
environment. And the problem with piclorum, one of the the things that's been known about it is it's very
00:00:53
persistent. It doesn't biodegrade very well. Picllorum sticks around for well
00:00:57
over a year. It stays in the water. It moves into groundwater and it's persistently in the environment after
00:01:03
it's been used for some period of time. The last time there was an EPA safety
00:01:07
study done was in 1995. And so this was before we had this capacity to do epigenomic studies like
00:01:14
what was just done to elucidate that even though a chemical might not be causing cancer immediately and you can't
00:01:21
apply it to a cell and see it trigger a cancer, the long-term use or exposure to
00:01:26
certain chemicals in our environment causes a change in the epiggenome, which means that these genes are being turned
00:01:31
on and off. And when certain genes are turned on or off in the wrong way, it can trigger cells in the tissue to start
00:01:38
to malfunction and go haywire and ultimately lead to cancer. They then took that piclorum exposure. And then
00:01:45
they looked at all the counties across the United States. They were able to gather data and they were able to look
00:01:50
at piclorum use estimates from the pesticide national synthesis project and try and deduce in places where piclorum
00:01:57
was highly used and not highly used. And once again, it elucidated signal, which
00:02:01
is that when pllorum was used in the environment in the counties more frequently, there was a much higher
00:02:06
frequency of colon cancer in those counties. This shouldn't just be a one-off research project conducted by a
00:02:11
team in Spain, but maybe should be a fundamental role that some of the government agencies play, which is to
00:02:16
stop Americans and the world from getting frigin cancer. Let's figure out the things that we got wrong in industry
00:02:23
and go back and delete them out of our food supply and out of our industrial

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Episode Highlights

  • Alarming Rise in Colon Cancer
    A significant increase in colon cancer among those under 50 raises serious concerns.
    “This rise in young people getting colon cancer has been pretty alarming.”
    @ 00m 19s
    April 28, 2026
  • The Role of Piclorum
    Research links the pesticide piclorum to higher colon cancer rates in certain counties.
    “When piclorum was used in the environment, there was a much higher frequency of colon cancer.”
    @ 02m 06s
    April 28, 2026

Episode Quotes

  • This rise in young people getting colon cancer has been pretty alarming.
    David Friedberg: Is This Pesticide Causing a Colon Cancer Spike in Young People?
  • Let’s figure out the things that we got wrong in industry.
    David Friedberg: Is This Pesticide Causing a Colon Cancer Spike in Young People?

Key Moments

  • Colon Cancer Crisis00:19
  • Pesticide Concerns00:40
  • Government Responsibility02:20

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