00:00:00
You have an envelope in front of you there that says confidential on the front of it. What is in that envelope?
00:00:04
>> It's a paper that's under embargo because the world thinks it's going to be very important and it's going to be a
00:00:09
lead article in the frontiers in science because this is a strategy to manage cancer effectively and we have a lot of
00:00:15
evidence to keep these people alive a hell of a lot longer. We have given hope to the hopeless
00:00:20
>> and you have a perspective on treating cancer and other metabolic diseases that
00:00:24
others don't have. >> Yes. But the problem is the field doesn't understand what I'm saying about
00:00:29
the origin of cancer. So everything comes back to mitochondria and all chronic diseases in cancer are the
00:00:35
result of damage to this and the science is telling us this. But the field of cancer has yet to accept it. That is a
00:00:42
tragedy. >> Are you pissed off about this? >> Well, who wouldn't be? There's 1,700
00:00:46
people a day in this country dying from cancer. That's 70 an hour. And it gets worse every single year. When is the
00:00:53
people going to wake up? So give me a prescription of how I should live my life to keep my mitochondria healthy.
00:00:58
>> So it all comes down to what you do to maintain the health and vitality of the
00:01:02
mitochondria that reduce the risk. But we are now in a new environment where we have massive amounts of highly processed
00:01:08
carbohydrates, inactivity, emotional stress, poor sleep habits and you chronically damage this organel. And
00:01:15
then if you look at the domestic dog, cancer is the number one killer of the domestic dog. But wolves in the wild
00:01:20
rarely have cancer. But the wolf is out running around eating natural foods. Yet
00:01:24
the dog is in an apartment somewhere gets a dog walker once a day, right? And the next thing the dog is obese and full
00:01:30
of cancer. >> And I want to give people actionable things that they can think about.
00:01:33
>> So this is what's really important. This is a bioenergetic road map to health.
00:01:38
This is what we call the zone of prevention. It's very hard to get cancer or chronic diseases when you're in these
00:01:43
zones. >> So let's talk about that. >> So this is super interesting to me. My team
00:01:49
given me this report to show me how many of you that watch this show subscribe. And some of you have told us according
00:01:54
to this that you are unsubscribed from the channel randomly. So favor to ask all of you, please could you check right
00:01:59
now if you've hit the subscribe button if you are a regular viewer of the show and you like what we do here. We're
00:02:04
approaching quite a significant landmark on this show in terms of a subscriber number. So, if there was one simple free
00:02:09
thing that you could do to help us, my team, everyone here, to keep this show free, to keep it improving year over
00:02:15
year and week over week, it is just to hit that subscribe button and to double check if you've hit it. Only thing I'll
00:02:20
ever ask of you. Do we have a deal? If you do it, I'll tell you what I'll do. I'll make sure every single week, every
00:02:26
single month, we fight harder and harder and harder and harder to bring you the guests and conversations that you want
00:02:30
to hear. I've stayed true to that promise since the very beginning of the DEO, and I will not let you down. Please
00:02:36
help us. Really appreciate it. Let's get on with the show. >> Professor Thomas Seaf Freed, what is it
00:02:45
that you've committed your life to doing, Thomas? >> Well, we're right now committed our
00:02:50
lives to managing cancer effectively uh without toxicity which is based on based on the science that I and other
00:02:59
others have done in this field. >> You have a perspective on treating cancer and other metabolic diseases that
00:03:04
others don't have. the mainstream should I say. >> Oh yeah. Well, mainstream doesn't have
00:03:09
it for sure. But it's based on science. I mean I'm my work is based on what Otto
00:03:15
Warberg the famous German scientist said from the 1920s30s and 40s. He clearly showed that cancer was a mitochondrial
00:03:23
metabolic disease. >> What does that mean mitochondrial metabolic disease? >> Okay. It means that the origin of the
00:03:30
disease resides in the organel called the mitochondrian. It's it's in the cytoplasm of the cell. It used to be
00:03:39
called still is the the powerhouse of the cell. Gives the cell the energy. >> I think we have a mitochondria. Could
00:03:45
one of my team bring in a mitochondria? >> Well, this is you have a a mitochondria
00:03:50
in here. Oh, here we go. >> You got one each here. >> Yeah. Well, see, this is the little
00:03:53
organel that you see. It looks like a bean shape, but it's actually a tubular network. These are tubes
00:04:01
>> and they respond dynamically inside the cell to uh both internal uh activities
00:04:08
as well as external activities. So you have to realize that at the time of conception
00:04:15
uh all of the mitochondria for the developing embryo are in the cytoplasm from the mother.
00:04:21
>> The cytoplasm >> the mitochondria are not in the nucleus. They're in the cytool. Oh, outside of
00:04:26
the >> outside of the nuke, but in the cell body itself. So all of the mitochondria,
00:04:31
they determine our destiny. They will determine how long you will live on the planet if if you don't have an
00:04:37
unfortunate accident or something like this. They have an expiration date. Different species die at different
00:04:44
times. You don't find people living 400 years. Mice live about two and a half years. Elephants live, you know, as long
00:04:50
as we do or whatever. But that's all determined by this organel. So you can see I have wrinkles and this kind of
00:04:56
thing. This is from living on the planet and this is from wear and tear on this organel which allows us to make energy
00:05:04
efficiently. >> So when this organel starts to falter with age uh you die you die from old
00:05:10
age. This organel has to be protected and respected if you would like to live a normal lifespan. But in diets and
00:05:18
lifestyles and way we are today we we we damage this organel and this organel then can present itself damage to this
00:05:26
organel which is a tubular network inside the cell. But let me say something else. It not only controls the
00:05:33
internal environment of the cell. It also controls the neighboring cells. The liver neighborhood the lung neighborhood
00:05:40
the colon neighborhood the brain neighborhood the gal neighborhood the neuron neighborhood. But they're all
00:05:44
come from the same origin in that cytoplasm and they determine the overall metabolic health of your body. It's a
00:05:52
systemic they communicate uh with each other across cells across tissues. I'll tell you this organel
00:05:59
controls a lot of what goes what that nucleus does. It tells the cell when to divide. It tells the cell when to slow
00:06:09
down. >> It's kind of like a brain but also like an engine room. >> It's kind of like that. Certainly
00:06:13
certainly the brain part of it is really mysterious uh in the sense of of how it
00:06:20
controls the destiny of the cell in the body. So sickness sickness disease cancer what do we know
00:06:28
about the role that this little thing plays in these chronic diseases and illnesses and cancers that so many
00:06:33
people suffer with? >> Yeah. Well, this is the organel that becomes damaged. Um and it can be
00:06:38
damaged in many many different ways. uh for cancer is what we have spent a lot of our time on and now we've moved into
00:06:46
the whole chronic disease issue because each each chronic disease can have different manifestations of ill health
00:06:54
to the mitochondria in a particular population of cells. But in the case of cancer which is what we call the most
00:07:02
serious of the chronic diseases creating the most trauma uh the most emotional distress but we have clearly shown based
00:07:12
on on many many works that any multiple things from our environment can damage this organel in a particular population
00:07:22
of cells in a particular organ. For example, when you talk about carcinogens, it's a chemical that causes cancer. How
00:07:30
does that chemical cause cancer? It damages the proteins and the lipids. These little squiggles are delicate
00:07:39
internal membranes. They they contain the proteins and the lipids that allows us to generate energy when we breathe.
00:07:47
Okay, you're breathing. I'm breathing. I take in oxygen. Oxygen serves as a kind
00:07:53
a a final acceptor for electrons that allows ATP uh to come out of this little and don't forget it's a tubular network
00:08:01
>> and ATP is the energy currency. >> It's the chemical energy currency. It allows us to enzymes to work allow
00:08:08
allows all the metabolic machinery inside of a cell to work optimally. >> So just to play this back to you so I
00:08:14
know I'm clear. Oxygen comes in because I breathe in. I then eat food >> in in that mitochondria. It does a
00:08:20
process and it spits out ATP as the energy. >> Well, and and the waste products of a
00:08:25
good energy metabolism would be CO2 and water. So, when we burn gasoline in an engine of a car, we break down the
00:08:33
octane, the carbon hydrogen bonds in an octane and and we have an internal explosion that drives pistons. Okay? The
00:08:40
exhaust is a lot of waste products uh from breaking down the M that we're doing the same thing inside the cell.
00:08:46
We're combusting carbon hydrogen bonds and that combustion of carbon hydrogen bonds is a graded process. So it's not
00:08:54
an immediate explosion. It's a it's a you're you're breaking down the carbon hydrogen bonds in a very precise way
00:09:00
producing ATP which then drives the entire machinery of the neurons and the rest of the body.
00:09:06
>> It can respond dramatically to energetic stress, emotional stress. Anyway, I gave
00:09:11
you an example of a carcinogen uh intermittent hypoxia like people who have sleep apnea. They stop breathing
00:09:18
for 30 seconds or more in that general and then they that creates rust RO and that's what carcinogens do ROS. These
00:09:26
are called reactive oxygen species. They damage those delicate membranes. And then what happens if it's too acute, too
00:09:36
stressful, the whole cell will die. the cell loses its energy and we get uh apoptosis or necrosis cell death. But if
00:09:45
it's gradual chronic over years, months, years, this organel loses its ability to produce sufficient
00:09:53
energy. But the the cell compensates interestingly enough by using these ancient pathways heirlooms of our
00:10:03
evolutionary past. So um because all life on the planet evolved in in oxygen but without oxygen in the dark uh these
00:10:14
cells grew like crazy. There was no they were single cells. They unbridled proliferation and all this kind of
00:10:20
stuff. They didn't have mitochondria. They had bacteria and the bacteria which this organel came from was a
00:10:27
fusion between one cell uh that had a nucleus and and was was fermenting through the cytoplasm and this bacteria
00:10:37
which is the mitochondria came in and now you have two different forms of energy. You have um the energy in the
00:10:44
cytoplasm, the ancient fermentation, and then you have this new form which can take in oxygen and generate energy much
00:10:50
much more efficiently than the airlumic. Listen, one of our big discoveries, if you can believe it. But you see that
00:10:58
space in the middle there? >> Yeah. >> That's called the matrix. And that's where the KB cycle, the TCA cycle, which
00:11:04
breaks down the food that we eat. But they have an ancient part of a fermentation mechanism inside because
00:11:11
before oxygen came every all life forms were fermenttors. They they produced energy without oxygen because there was
00:11:18
no oxygen. We had to wait for those bacteria to make oxygen through a photosynthetic process. But all
00:11:24
organisms were fermenttors in the beginning after this organel came in and was able to take in oxygen make energy
00:11:30
really really quick. But in that matrix they have a uh in the cycle there's a little pathway there that makes energy
00:11:37
without oxygen from the evolutionary past. So we have it in the cytoplasm of the cell because they can use they can
00:11:43
ferment in the cytoplasm. But this organ that our big discovery with the work of
00:11:48
of Christounis from semlice university he's the world leader on that little pathway. When this organel becomes
00:11:57
impaired, these ancient pathways of energy through fermentation arise. Okay, they they try
00:12:04
to replace the lost energy from the efficiency of this organel. That space starts throwing out ATP
00:12:12
from glutamine. It's another fermentation fuel and and it's making it's making ancient energy in the
00:12:20
sophisticated organel that was that was that that evolved to make efficient energy. So let me let me tell you. So
00:12:28
you get you asked me what about damaging this organel and what happens if the damage to oxidative phosphorilation
00:12:35
>> what does that mean? >> Which means energy through oxygen >> is too acute the cell will die.
00:12:43
Cyanide is a a perfect example of this. You take a mouse or a rat or a person and you drink Kool-Aid, the cyanide
00:12:50
laced Kool-Aid, you die because what happens is that cyanide binds to the protein that's going to um um use oxygen
00:12:59
for energy and the whole system shuts down. >> Suffocates you basically. >> Yeah. You die in instantly. Um and there
00:13:05
are other things that can kill uh can kill uh quickly aid and a variety of other chemicals but for chronic diseases
00:13:12
it's usually u not an acute stress on this organel it's a it's a chronic stress and in cancer what happens in a
00:13:21
particular tissue whether it's bone lung bladder brain they gradually compensate
00:13:27
with these ancient fermentation pathways so so this thing this organel cell signals to the nucleus I'm suffoc I'm
00:13:38
not getting enough energy. Um so the nucleus turns on the transporters on the surface of the cell to bring in fuels
00:13:48
that will elevate energy through what we call uh oxygen independent mechanisms. This is an oxygen dependent organel.
00:13:55
This gets most of its energy because we breathe, all of our cells are using oxygen and the CO2 that we're blowing
00:14:01
out and the water that will be collected in the form of urine when you might put
00:14:05
uh other waste products in there. That's efficient metabolic homeostasis. This organel makes not only the cell but the
00:14:13
whole body in a state of of metabolic homeostasis where all systems are working at optimal efficiency. But with
00:14:21
chronic disruption, uh, smoking, uh, lack of exercise, you can go right down the list of all of the different things
00:14:28
that can elicit cancer, any kind of carcinogens, microplastics, forever chemicals, uh, uh, uh, glyphosate and
00:14:37
any of these kinds of things that would chronically damage uh, the ability of this organel to produce energy. Viruses,
00:14:44
ankcoenic viruses, inflammation. you have chronic inflammation. Any of those things damage this the sophisticated
00:14:52
ability of this organel to produce sufficient energy. That's why that's why um uh the ankcogenic paradox which we
00:14:59
solved. >> What's the ankcogenic paradox? >> That was the paradox that was first put
00:15:03
out by Albert St. Gorgi Hungarian uh scientist who received a Nobel Prize I think for vitamin C. He said he said he
00:15:12
was very interested in cancer and living systems. He said there's a paradox. He said we know multiple things in the
00:15:20
environment can elicit cancer. We've identified these ankcogenic viruses, chronic inflammation, carcinogens,
00:15:27
intermittent hypoxia, rare rare germline mutations. He said we don't understand the common pathophysiological
00:15:36
mechanism by which any of those provocative agents would elicit disregulated cell growth which is
00:15:44
cancer. When you talk about cancer, what do people say what is cancer? It's cell
00:15:48
division out of control. It's disregulated cell growth. This organel determines when cells should divide and
00:15:57
when they should not divide. It regulates the destiny of the cell. So what happens when this organel becomes
00:16:04
chronically impaired? It falls back on these ancient pathways, these or or these or um uh pathways that existed
00:16:13
before oxygen came into the environment where all the cells were disregulated in
00:16:17
the growth because they didn't have this regulatory system which is the mitochondria coming from a from a
00:16:23
bacteria. >> So let me play that back to you in a way just so I you know make sure I
00:16:25
understand. >> I I know it can be kind of deep. >> Okay. So in this mitochondria here that
00:16:30
I have in front of me, there is an ancient um because this came from the >> bacteria
00:16:36
>> a fusion of bacteras a long long time ago. >> Yeah. >> The old bacteria >> about several billion years ago
00:16:42
>> used to be very selfish and just think about itself. It used to grow on its own
00:16:45
and didn't communicate with anybody. Had its own way of growing and multiplying that was really not um in cohesion with
00:16:51
anything else. That is still in there somewhere. And although now in its modern form because there's been that
00:16:58
fusion it grows thinking about the wider organism um when it becomes damaged it falls back on that old selfish way of
00:17:08
growing and sometime and that's kind of what can cause cancers. So if you if there's stresses on this which could be
00:17:15
all the car carogenic things you described then sometimes this falls back on that prehistoric selfish way of
00:17:22
growing where it doesn't think about the wider organism. >> It's close um um in the sense of
00:17:29
thinking we don't know about that we just know the consequences of what happens when it falls back on those
00:17:35
ancient pathways. Now here's the situation. People knew from Otto Warberg said cancer is a energy problem in the cell.
00:17:46
This why would the cells start to ferment and produce a massive amount of fermentation waste product which is
00:17:53
lactic acid. Even in the presence of oxygen, 100% oxygen, they're still fermenting. Why? That shouldn't happen.
00:18:02
Uh when you and I hold our breath or have a heart attack, let me tell you something. This is really remarkable and
00:18:07
this is another piece of information that got us on this whole thing. When people have heart attacks, uh they stop
00:18:14
breathing, the heart seizes, okay, the bloodstream immediately fills with these fermentation waste products which are
00:18:21
lactic acid and the other one which we now know is suinic acid. Okay. Wow. These two waste products. Now, if you
00:18:30
don't start breathing in a short period of time, you're going to be dead. >> Mhm. And you and what you die because
00:18:36
the neurons in your brain cannot sustain this kind of fermentation energy for very long. As soon as you the heart you
00:18:44
you give them cardiac massage and whatever the guy's heart starts beating again. The lac the waste products
00:18:51
of lactic acid and suinic acid go away. They disappear because you're breathing now. You don't need to ferment when you
00:18:57
have oxygen in the environment. And it's and the mitochondria can can utilize the
00:19:01
oxygen in the environment. cancer cells to Warberg said it's the weirdest thing.
00:19:07
These cancer cells um continue to ferment even in 100% of oxygen. Why are they doing that? And he speculated that
00:19:17
this organel was damaged. Irre irreversible damage to the organel happened in these cancer cells. He
00:19:26
didn't have an electron microscope at the time. He didn't have the sophisticated tools that we have today.
00:19:32
So he projected that all on biochemistry at that time. He was a biochemist and he
00:19:37
said you don't should not produce fermentation if you have ox oxygen should shut that off and these guys
00:19:43
should return to a normal metabolic homeostasis. And he said that's because there's something irreplace irre
00:19:48
irreversibly damaged in this organel. So a lot of people attacked him and they said oh we don't have any evidence for
00:19:54
that. Here's the beautiful thing. Some cancer cells continue to take in oxygen and make ATP. Therefore Warberg must be
00:20:00
wrong. Uhhuh. We showed that that we showed the cancer cell takes in oxygen, but it's not making energy through ATP
00:20:08
in any great amount. It's using it for ROS react these radicals that further damage and cause the DNA mutations that
00:20:15
everybody is chasing. It's all downstream effects of damage. >> So what does this what does this mean in
00:20:21
simple terms? Because I'm aware a lot of my >> Well, it it means I say, okay, so so I
00:20:25
have disregulated cell growth. That's ultimately what the problem we're dealing with. We can't control how these
00:20:31
cells are dividing. We're throwing all kinds of crazy stuff at them. Trying to poison or radiate surgically remove
00:20:36
them. We're trying to do everything to stop this disregulated cell growth. >> Mhm.
00:20:41
>> So when we look at this organel under the micro under the electron microscope,
00:20:45
we find these cry are often missing. You have what they call ghost mitochondria.
00:20:49
You got the shell but nothing inside or if they're inside, they're all deformed.
00:20:53
So we know there's a foundational principle in biology. Structure determines function. If the structure is
00:21:00
abnormal, the function will be abnormal. This is known to all biologists except oncologists. They don't seem to
00:21:07
understand it. >> What's an oncologist? >> Those are the people who study cancer.
00:21:11
>> So, what are you then? >> I'm a biologist. >> You're a biologist. >> Yeah. I mean, when we know that if the
00:21:17
organel is damaged, you're not going to be able to produce energy efficiently by
00:21:20
oxidative phosphorilation. Okay. >> I think you're a bit further down the road, Thomas, than a lot of my viewers
00:21:25
are. for me hearing that there's this energy engine in my cells that and there's trillions of them or billions of
00:21:32
them and they also communicate with each other and when this becomes stressed or
00:21:38
hurt or damaged because of lifestyle choices that I make energy production and inefficiency will change and that
00:21:44
could cause this to die or malfunction in some way that is as for me I go I've got it
00:21:49
>> okay that's a major step forward now we build upon that yes now we build upon
00:21:55
that okay so so here's the situation we've discussed cancer cells all of them that we have ever looked at have defects
00:22:04
in the number structure and function of that organel okay I have looked at I published that big paper where I spent
00:22:13
uh over a year of my time going through the ancient the well the early electron microscopy literature warberg didn't
00:22:20
have that opportunity because that technology was not there for him. So he speculated that based on the
00:22:26
biochemistry, but I went back and I looked at these um electron microraphs of mitochondria in various cancers and
00:22:33
they're all damaged. There is few of them that risk Christ are gone. I work with some of the best like Aris Aris
00:22:40
Mendy Marillo uh who is a world leader in beautiful electron microscopy of of cancer cells and you can see and and all
00:22:47
the damage uh under his magnificently beautiful and one we have a couple of papers but let me tell you something
00:22:52
else Stephen in the cytoplasm these organels are also in contact with other cellular membranes like the endopplasmic
00:23:00
reticulum there's a lot of we call organels inside a cell you have the nucleus you have the mitochondrian
00:23:07
you you you have loss. There's intimate contacts between some of the other membranes, mitochondrial associated
00:23:14
membranes we see and they're also abnormal when you look at them under the electron microscope.
00:23:19
>> The ones it's talking to are abnormal. >> Yeah. The ones you can see the the mitochondria are abnormal and the
00:23:24
membranes that contact them are abnormal. Okay. And that intimate contact >> uh I'll get into the calcium signaling a
00:23:30
little bit later which controls the destiny of the cell. Why the cell is growing out of control? Well, first of
00:23:36
all, it's fermenting. Okay, that means it's getting energy from sources other than oxidative phosphorilation. You can
00:23:41
take a cancer cell and and treat it with cyanide or aid or in absence of and it's
00:23:47
still living. It's still growing because it's not using >> the oxygen path. >> They're not using the oxy falling back
00:23:53
on on on oxygen independent mechanisms which are called fermentation. So I understand that to be that there's a
00:24:00
malfunction in a mitochondria which means that it no longer uses its oxygen pathway
00:24:05
>> as sufficiently as it should. There's always some residual level >> and it finds another way to make the
00:24:10
energy which is how it survives. >> Yes. >> And then it stops communicating with the
00:24:13
rest of the cell. >> Well, it actually communicates with the nucleus >> to open up the floodgates to bring in
00:24:18
the fuels that drive this fermentation energy. >> It gets more and more greedy. It it has
00:24:23
to because you're you're taking an organel that produces energy highly efficiently. Okay. Um like 34 to 36 ATPs
00:24:32
>> with oxygen >> with oxygen. And now you're you're trying to replace that with fuels that
00:24:38
give you two uh two moles of energy. Uh >> so it's inefficient >> very and then and then you get you get
00:24:45
two out of the in so you're getting four. So you you you have to take in in order to make up the efficiency you must
00:24:52
have a tremendous logistic you must have tremendous supply >> of >> of the fuels that will give us energy
00:24:58
>> which are >> glucose the sugar >> and the amino acid glutamine >> okay >> okay our bodies are loaded with
00:25:05
glutamine that's the most abundant amino acid in our bloodstream and evolution provided that for us because if we stop
00:25:11
breathing we use that fuel to keep the cells alive we our gut is controlled by glutamine Our immune system uses
00:25:18
glutamine. >> What is glutamine? >> It's an amino acid. Okay. >> Which we make from food.
00:25:23
>> Yeah. Which we can make from food. True. Or they call essential and non-essential
00:25:27
amino acids. Essentials are from that we must eat. We must have certain foods that provide these. Glutamine is
00:25:33
considered a non-essential amino acid. It's an essential amino acid biochemically called non-essential
00:25:39
because we can make it from sugar. >> But basically, it's the most abundant amino acid in our body. I think I get it
00:25:46
now. >> Okay, feed me back. Tell me, let me let me test you. There should be a button
00:25:52
just down below here. And if it says subscribed, you're already subscribed. If it says subscriber, that means you're
00:25:58
not yet. And if you're not subscribed, please could you do us a favor and hit that button? It helps the show more than
00:26:02
you know. And according to the algorithm, you're someone that watches our show, but you haven't yet hit that
00:26:06
button. Thank you so much. When we fall, the mitochondria falls to that prehistoric pathway where it starts
00:26:13
making energy in a really really inefficient way without using oxygen in the same way. It starts relying now on
00:26:20
glucose and glutamine um to produce that energy which is a much less efficient source of energy. So it gets a bit more
00:26:26
greedy. It needs much more to make the same amount of ATP which is energy. >> Mh.
00:26:30
>> So these a cancer cell can be very very greedy. It's not responding to oxygen in
00:26:34
the same way and they they're a bit more selfish. they start they start sort of multiplying without thought of the
00:26:40
broader organism. >> Yes. Yes. >> So the question I have is how does this happen?
00:26:46
>> Malfunctioning of the m what is it that I've done? You know what I ask this question?
00:26:50
>> Okay. Well, I Okay. >> It's because children can get these cancers >> or a 90-year-old can get the cancer. And
00:26:57
it doesn't appear to me that a three-year-old has necessarily made life choices yet
00:27:02
that could >> but as I said when you consider forever chemicals uh that are in the environment
00:27:08
uh things that we have that we use in our technologically advanced societies can get through the placental wall and
00:27:16
get these into the ch into these children's uh organs. Um you know you have to put it together. We usually it's
00:27:23
a a constellation of things because don't forget I said carcinogens. Some of these carcinogens are fat soluble. Some
00:27:29
of these carcinogens can get in and damage those during early stages of development. People always say how you
00:27:35
explain brain cancer in in a in a six-month old baby. Okay. What what did he what what he he wasn't smoking and
00:27:43
drinking and partying all the time, but but his the mitochondria and a population of cells in his brain became
00:27:49
damaged. And that damage then led to this disregulated cell growth because the organel controls when cells should
00:27:56
divide and not divide. And then and then where's the energy coming from? How do you how do you take a highly
00:28:03
sophisticated piece of an organel and making energy so incredibly efficient and now we're using energy.
00:28:10
So uh this organel signals to the nucleus called mitochondrial stress response retrograde signaling. The
00:28:17
nucleus acts as a respondent to what this organel wants. So the nucleus then ankco genes which that you've heard a
00:28:25
lot about. They open the floodgates to bring in the glucose and glutamine that allow the cell to grow in a disregulated
00:28:32
way. So we've as you said they go back to these ancient fermentation pathways where there was no regulation because
00:28:39
this organel was not part of the problem part of the situation the regulation. So
00:28:43
is there what are the lifestyle factors that are causing this to were drastically increasing the probability
00:28:48
of this happening. >> It's not necessarily what the person did or all cases it's what the person was
00:28:54
exposed to uh that could have elicited this. That's the ankcoenic paradox. So uh we have shown uh that inflammation
00:29:04
produces these cytoines when you have an inflammatory heat in inflammation they they damage the ability of this organel
00:29:12
to make energy efficiently. Chronic inflammation is known to be a risk factor for cancer. Chronic inflammation
00:29:21
intermittent hypoxia carcinogens. >> What's intermittent hypoxia? >> It's like the sleep apnea that kind of
00:29:27
thing. Warberg had clearly shown that intermittent hypoxia on cells would damage the efficiency of oxidative
00:29:34
phosphorilation leading to a compensatory fermentation. So you have to compensate because let me tell you if
00:29:40
you don't compensate you're dead. The I mean the cell dies. When we look at the populations around the world that have
00:29:47
the most prevalence of cancer, it doesn't appear to be some of the countries like Nijer, Gambia, Nepal
00:29:57
consistently rank at the very bottom for cancer cancer incidents. Conversely, high-income countries like Australia,
00:30:03
New Zealand, and the United States have the highest rates of cancer. Why is that?
00:30:09
>> It's because of our um technology. Uh we are still paleolithic man and uh our
00:30:16
biology has allowed us to store energy efficiently uh because of times of famine. We are
00:30:25
now in a new environment where we have massive amounts of highly processed carbohydrates, inactivity, emotional
00:30:31
stress, we have poor sleep habits. You you pile all those together with availab the exposure to carcinogens and whatever
00:30:41
and you chronically damage this organel and uh in some organs you can get breast
00:30:47
cancer if it's a lung if it's a whatever it is that organel becomes chronically damaged in some populations of cells in
00:30:55
a particular uh in a particular organ and and you can elicit disregulated cell growth as the result of that. You know
00:31:03
what I find is in in that in the paper that we have with the chart uh if you can keep your mitochondria healthy
00:31:10
because don't forget Paleolithic man our ancestors from 500,000 years ago uh or modern men like you said in these
00:31:19
countries living according to traditional ways with minimal in interference from modern diet and
00:31:25
lifestyle issues have lower amount of cancer in general and this is what Albert Schwitzer found the the famous
00:31:32
humanitarian physician. He was specifically looking for cancer in African tribes and he said remarkably
00:31:38
it's extremely low. What what are these guys doing where western society has has
00:31:43
a lot of cancer and these Africans have living living according to the traditional ways. So they have a lot of
00:31:49
exercise. They're eating all organic foods. Uh they're not under the same kind of stress or exposure to chemicals
00:31:54
that modern societies have. And you find out you have very low cancer. Like for example, uh dogs are all evolved from
00:32:01
the wolf. Uh wolves in the wild rarely have cancer. The domestic dog, cancer is the number one killer of the domestic
00:32:09
dog. What is the dog doing that the wolf? The wolf is out running around eating natural foods. The dog the dog is
00:32:14
in an apartment somewhere gets a dog walker once a day, right? And the next thing the dog dog is obese and full of
00:32:20
cancer. So it all it all comes down to what what you do to maintain the health and vitality of the mitochondria that
00:32:28
reduce the risk and that's what this chart I'll show you has reduce the risk of damaging this chronically. Okay. So
00:32:36
that can explain in large part why modern societies are struggling with chronic diseases not only cancer we have
00:32:44
diet type 2 diabetes we have obesity we high blood pressure we we have a whole even neuroscsychiatric problems. If you
00:32:51
can protect and keep this organel healthy, you reduce risk. Now people say, well, cancer has to be genetic
00:32:58
because we have inherited genes that put us at higher risk like the Bracka one for breast cancer and the leaf ramen for
00:33:05
variety of other cancers. Our paper in this pile done by Bob Kaplan uh he went through uh and looked at all the genetic
00:33:14
risk. >> Which paper is it? >> Um it's one of the ones published in oncology. But none of these mutations
00:33:20
are 100% penetrant, meaning that they're secondary risk factors. A primary risk factor would be every time that mutation
00:33:27
is there, 100% of the people because I work in Tesax's disease. I work in inborn errors of metabolism. Those
00:33:33
mutations are 100% responsible for that condition. There's no gene mutation that's 100% pen. You have that gene,
00:33:39
you're going to 100% get cancer. Uh most of them are are uh um are what they call
00:33:44
incompletely penetrint. So what does that tell us about the nature of >> well it tell and then we went back what
00:33:48
Bob did is he went back and he looked at what every one of those gene mutations in some way disturbs the efficiency of
00:33:57
oxidative phosphorilation in that organel >> in the mitochondria >> in the mitochondria we we looked at we
00:34:02
have all the evidence all the risk factor all the genetically just just the front page there I was going to show you
00:34:09
the hard data but you got so anyway that all of them damage this the efficiency of energy through through through this
00:34:16
organel. So that's like carcinogens, that's like um viral infections. The viruses that like hepatoma and
00:34:24
papilloma, they they their their products will go in here and damage it or they will replicate inside this
00:34:30
organel, screwing up the efficiency, causing a compensatory fermentation, causing the disregulated cell growth
00:34:37
through abnormal calcium signaling, causing cells to no longer uh be responsive to their neighbors. Is that
00:34:44
clear? If I can make you understand this, we can make everybody understand this.
00:34:48
>> Yeah. So, the the reason I uh spend a lot of time asking why and asking for clarification is because when I do the
00:34:55
show, I then go out into the real world and I meet the people that listen. >> Yeah.
00:34:58
>> And one of the groups of people that listens are young offenders. And when I went and visited them, I pointed at the
00:35:03
episodes that I thought would help them. Yeah. And a young one of the young offenders said to me, "I can't listen to
00:35:07
that episode because the words you used were too big." >> And I remember thinking to myself,
00:35:10
>> "Okay, that I get that all the time, but guess what? Now we have AI and you can
00:35:15
take this statements and put it into AI right on the and and it'll it'll it'll dumb it down for you.
00:35:23
>> So So that's a tool that we previously did not have. >> So So I use that all the time. I said
00:35:30
when you hear me speak like this, don't think I'm arrog I I I these are the terms that we use
00:35:35
when you're part of the academy. Yeah. >> Okay. But we can take those terms now and AI can do a wonderful job in in in
00:35:41
synthesizing. Oh yeah, I know what he's talking about now. But without that tool, then it becomes like you said,
00:35:47
well, I can't understand anything. >> I've got 60 seconds and I'm going to show you how much I can get done because
00:35:53
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Big opportunity. I am not kidding. Give it a try. I really want to just make sure I tick off the box of um cause
00:37:50
factors. So you mentioned stress, >> you mentioned sleep. >> I currently don't have cancer as far as
00:37:57
I'm aware. God forbid. Um but I but I want to do everything I can to prevent the probability. Yeah.
00:38:02
>> And I from what I've understood that means protecting my mitochondrial function.
00:38:06
>> Yes. >> By living a lifestyle where I'm not creating this sort of like crazy oxidative stress on the mitochondria.
00:38:12
>> Right. >> So give me a prescription of how I should live my life to keep my mitochondria healthy.
00:38:17
>> Well, that's why we developed the glucose ke ketone index calculator. the first biomarket tool that can allow
00:38:22
people to know the level of health of their mitochondria because um when you shift from carbohydrate fuel
00:38:30
to lip lipid fuel, >> what's lipid fuel? >> Fat. >> So ketones, >> ketones are a water- soluble breakdown
00:38:37
product of fatty acids. >> Okay. So we store atapose tissue. We store fat >> which is the belly fat
00:38:45
>> all over. We have fat on our >> on the outside. >> Yeah. So on the outside that was there
00:38:50
because as a species we had to survive in the most harsh environments and we were um food was not always there. So we
00:39:00
had to survive all kinds of famine all kinds of absence of food. Our bodies are so our it's a machine that was home over
00:39:09
millions of years to be super efficient. So glucose is gold sugar. Okay. You either burn it or you can store it as
00:39:18
fat. Okay, that's that's the key. But when you have you're not bringing in sugar, that stored fat now moves into
00:39:25
the bloodstream, goes to the liver, and it's like taking a branch and putting it
00:39:29
in a chopper and you outcome these little soluble ketone bodies. They're breakdown products of longchain fatty
00:39:36
acids. They can replace sugar for the brain, for the muscles, for most other cells in the body except ariththraittes,
00:39:43
but they can replace they can replace the energy of glucose. Okay? So, uh, and that's how we evolved. But we're now in
00:39:52
an environment where we have massive amounts of highly processed carbohydrates and we we don't want to
00:39:59
pee them out unless you have diabetes or something. So, we store them as fat. So
00:40:03
we have an obesity epidemic as the result of our evolutionary ability to store energy which kept us alive as a
00:40:10
species because if we were unable to store the fat in 500,000 we would have all been extinct. You and I this
00:40:16
conversation would never exist. >> We would never have existed as a species except for our ability to store energy
00:40:22
and we burn energy efficiently in these organels. So this is all a very highly efficient machine. So when we lose that
00:40:29
ability, uh when we have so much energy in the environment, stress, no exercise,
00:40:34
all this, we store more and more fat, we produce an an environment that's very damaging to this organal.
00:40:41
>> Well, say that again. So how does stress impact that? >> Stress elevates corticosteroids. When
00:40:46
you're under stress, you get into a fight, you get into an argument, or you're stressed out by business deal
00:40:51
going bad, whatever. uh corticosteroids elevate elevate blood sugar contributing
00:40:57
to uh systemic inflammation. It's okay for a short period of time to be pissed off at something. But it's the chronic
00:41:04
stress, the chronic like looking at the cell phone, doom scrolling, all this kind of crazy stuff while eating the big
00:41:10
Twinkie, doom scrolling, eating Twinkies, not moving. All of this creates uh stress on this organel in
00:41:17
some population of cells. >> It makes it work harder. It's damaging because you produce reactive species
00:41:23
that damage the efficiency of this organel to produce energy effectively and that either will kill the cell
00:41:31
gradually if it can't comp use compensatory fermentation or predispose you to cancer. So either way is
00:41:39
unhealthy. So we have chronic disease. Cancer is the number one big dog in the chronic disease world. I mean it's the
00:41:44
one that people fear the most. um type two diabetes, cardiovascular disease, you know, dementia, uh all of these are
00:41:53
part of damage to this organel in one way or another. In like I said for Parkinson's disease, when that organel
00:42:00
gets damaged, the cells of the substantion aigrate die. They are incapable of compensating with
00:42:05
fermentation. So they up and die. Cancer is very rare in neurons of the brain. Neurons the gal cells of the brain form
00:42:13
these brain tumors mostly but neurons can't compensate with fermentation so they die. So you you either get comp
00:42:20
compensatory ancient fermentation leading to disregulated cell growth which we call cancer or we get cell
00:42:26
death leading to chronic diseases. >> What about sleep then? What's going on with sleep that's causing
00:42:30
>> sleep is a way we can restore the energy efficiency of the mitochondria >> if we're well slept.
00:42:34
>> If we have good sleep. Yeah. You know everybody feels good when you have a good night's sleep. your body feels
00:42:38
rejuvenated because you're not you're not stressing out. You're reducing the ability of this organel to manage the
00:42:46
the the the metabolic uh environment. uh if you're up all night and you're and you're like stressed out and you're
00:42:52
never given this uh organel in a particular cell in a particular part of the organ of the body, you know, you you
00:42:59
get neuroscychiatric problems, you can get digestive problems, you can get cancer, you can get type 2 diabetes, you
00:43:06
have a whole and we put it in the paper there, all the different stress, all the
00:43:09
different things that can chronically uh or acutely damage oxidative phosphorilation.
00:43:14
>> So sleep basically gives the mitochondria a little bit of a break. Yes. It's a it's it gives your whole
00:43:19
body a break, let's be honest. So, so, but you you pile those things on together. Lack of exercise. Our
00:43:26
ancestors, what do you think our ancestors, you know, how hard it is to run down and kill a big buffalo or a
00:43:30
woolly mammoth? I mean, you're you're exhausted after doing something. As a matter of fact, you chase these animals,
00:43:37
uh, you separate. And this is another thing that was really interesting. Came out of Israel. I think it was last year.
00:43:42
They looked at the cavemen, what they were eating. they were eating the the strongest members of the herd uh leading
00:43:48
to the indirect extinction of these animals. They found out that if you can eat the strongest member of the herd,
00:43:55
you'll get the vitality of that uh of that or buffalo or elephant or whatever the hell they were eating because they
00:44:01
knew the marrow and the and the the physiology of that of that organism at that point in its life could provide you
00:44:09
with the strength that that had. Now, when you eat the strongest members of the herd because you want to be tough,
00:44:15
you're putting the old and the young at vulnerable to predators leading to the extinction. Uh, and this is what a big
00:44:22
paper came out of out of uh, Israel. They looked at these cavemen, what they were eating like 500,000 years ago or
00:44:27
whatever they're doing. So, humans indirectly caused extinction of other species in part in not in part because
00:44:33
they were eating the toughest guys in the herd. So, because they felt that if I eat those guys, I'm gonna be strong
00:44:39
too. And in a way, they're right. But all of it has to do with the energy efficiency of your muscles, your brain,
00:44:45
your ability to be resilient, endurance. I'm telling you, these guys were chiseled. They they weren't dying from
00:44:54
type 2 diabetes, cancer, right? Dementia. They were dying from infections and injuries and child
00:45:01
mortality. Uh we're mostly killing our paleolithic ancestors. But when you bring your body back into a low glucose
00:45:07
ketone, you're actually going back like you were. This is why we developed the glucose ketone index.
00:45:13
>> What is in that envelope in front of you? >> Well, this is um it's a paper that's
00:45:16
under embargo because they they think it's going to be the world thinks it's going to be very important and um and it
00:45:23
is. So, and what it is, this is a um a way to keep that organel healthy. So this is a way to manage uh um energy
00:45:36
efficiency in the body. >> And this hasn't been released yet. >> It hasn't been released. Okay. It's
00:45:41
coming out. It's a it's going to be a lead article in the frontiers in science. And not only that, we the paper
00:45:47
the paper was written uh for the scientists and then the journal decided to make a second copy
00:45:55
for they call young minds. So letting kids that are like 8 to 12 or 14 years old synthesize it down and and and one
00:46:04
of my colleagues said that's probably what most people will be reading because they don't want to know about the
00:46:09
bioenergetics that actually goes on inside this organel to explain why this chart means something.
00:46:15
>> And you've been working on this for some time. >> Well, I I I built the GKI. So let me
00:46:19
tell you the story. There was a woman uh an American woman a lawyer Trudy Dupant
00:46:24
who uh developed um a kind of a brain stem tumor and after I wrote my book that book there that's my only book
00:46:32
anyway Trudy Trudy wanted to use this metabolic therapy she stayed alive much longer over 10 years with this we kept
00:46:40
the she eventually passed away unfortunately but so I was measuring because we knew that the tumor cells
00:46:47
needed sugar to grow out of Worberg showed that and many other people show that and they can't burn ketones because
00:46:54
because the fatty you need a very efficient mitochondria to burn ketones for energy. Our normal cells can burn
00:47:03
ketones for energy and that gives us tremendous uh uh we can actually breathe lower oxygen more energy if you have
00:47:10
efficient if you can burn ketones efficiently in this organel. But if the organel is damaged, they can't use the
00:47:16
ketones. They can't burn fatty acids or ketones, which stores lipid drops. It's one of these big papers here. These
00:47:24
Stephen, you can't believe how people misinterpret information. They see droplets of fatty acids in the cytoplan
00:47:29
say, you see the cancer cell needs all that fatty acid. No, they can't. It's there to protect them. If they try to
00:47:33
burn it, they blow this up and die. So there is a storage of fat. They can't burn fatty acids or ketone bodies. So, I
00:47:39
knew cancer needed glucose, and I knew cancer couldn't burn fatty acids or ketones because this organel is is
00:47:45
broken. So, I'm measuring glucose and ketones independently in Trudy. She's doing the
00:47:53
finger prick thing, sending me the information back and saying, "Oh, here's my glucose. Here's my ketones."
00:48:00
>> Okay, so I have a a ketone glucose reader in front of me. >> Right. Right. >> If I put my blood on this strip, it
00:48:06
tells me my glucose levels. If I put my blood on this strip, yeah, it tells me my ketone levels.
00:48:10
>> Right. Right. But if you if you look at them independently, >> glucose is very volatile, very variable.
00:48:17
>> And this is why I developed the glucose ketone ratio because Trudy had a parking
00:48:22
spot that was for handicapped because she had a cane. Her brain stem gloma was preventing her from walking as
00:48:30
effectively as normal people. So she somebody took her parking spot. She was So she ran upstairs and took
00:48:39
her blood sugar and it was 186 milligram per deciliter. It was very very high. So
00:48:45
and I know she was on a ke ketoic diet and and she emails me and says I'm going to die. My cancer is going to grow fast.
00:48:51
What's going on? She said my blood sugar is like 186 and you know it's supposed to be you told me it was supposed to be
00:48:56
60 or you know 50 65 or in that zone. She says so I said what's your ketone level? Oh, it's still, you know, like
00:49:02
you just had point4 millmer or I think it was 0.9 millmer. I said, well, that didn't change, right? No, just the sugar
00:49:09
changed. So, I said to the students that were working with Josh Fidenbower, I said, Josh, this this trying to measure
00:49:16
these two independently is a You can't this is hard to figure out. So, what we decided to do in miller
00:49:21
because glucose comes out in milligram per deciliter whereas ketones come out in millimmer. So we had to convert
00:49:27
glucose to millimmer and divide it by the ketone in millimmer and then you get a number that's not all over the world.
00:49:34
It's very stable. So so we were able to because of Trudy that one cancer patient
00:49:41
we developed the ratio of of this. Then later on we realized that this ratio is a statement of how healthy your
00:49:49
mitochondria actually are. So when you when you have these low ratio you're in paleolithic man. you're back in the zone
00:49:56
where we didn't have chronic diseases because we didn't have damage to the organel that would cause those diseases.
00:50:02
So, paleolithic men think where are they getting their pastries? Where where are
00:50:06
they getting their cakes and sweets and all this other they didn't have it. They
00:50:10
weren't there because of of choice. They were there because of circumstance. So,
00:50:14
our new and we learned paleolithic man was always in some sort of a state of some ketosis because they wouldn't have
00:50:21
food for periods. They were very active in their exercise. They had they didn't have chronic diseases, but they had
00:50:27
other kinds of diseases. So, so then um my my my my student um Derek Lee, myself
00:50:35
and Christo Shinopoulos, we started to make a ratio chart. Now, these are the numbers that you get when you divide
00:50:41
your sugar by your ketones. >> Okay. So, my sugar by my ketones. So, if I did my glucose measure now on this
00:50:47
little >> Okay, let's see what your GKI is. >> Oh, you want me to do it? Okay. >> Okay. What? You had a glucose. You had a
00:50:52
a ketone was 0.4 millmer. >> Yeah. >> Okay. What was your sugar? >> I haven't. >> So, we can divide. We can do the divi
00:50:58
division right now and tell you what you have. >> You can get these little uh ketone
00:51:02
>> Oh, yeah. It's a keto mojo. And you can also get them now for for uh >> Wow, these guys skilled at doing this.
00:51:08
>> I travel with one of these, believe it or not. >> Yeah. >> So, I I have one all the time.
00:51:13
>> Wow. >> 90. >> 90. Okay. So, you have to you have to divide. You have to divide. You're not
00:51:19
getting the Doesn't this give you the push button and give you the GKI right away? Cuz the new ones have it. So, you
00:51:24
have to divide 90 by 18 and you get a number. >> Uh, five. >> Five. So, divide five by 0.4.
00:51:32
>> 12.5. >> Okay. So, here you are. 12.5. You're down here in the in the in the prevention zone.
00:51:40
>> Ah, nice. >> Okay. So, so you This is where Paleolithic man mostly lived. Paleolithic man lived in the yellow
00:51:49
green zones because they didn't have access to all of the things that would drive up your blue blood sugar and keep
00:51:56
your key when your blood sugar goes through the roof your ketones are really low because insulin is now driving it
00:52:01
up. So So that's good. Um 12, huh? >> So I I did the I did the carnivore diet for a week.
00:52:09
>> Uh eating big ribe eyes. You like ribeye steak? >> Yes, of course. ribe eyes, bacon and eggs, lamb. I I so
00:52:18
I did it for a week and um I was able to get down to 10. >> Okay. >> Okay. And I could get lower, but I was
00:52:25
loving the ribeye so much I ate a little too much of it. Right. You have to be have some level of discipline. Yeah.
00:52:30
>> So, uh so so but people people this is what we call the zone of prevention. It's very hard to get cancer or chronic
00:52:38
diseases when you're in these zones because you're keeping this organel quite healthy. When you live in these
00:52:44
zones consistently, >> you you don't have to live consistently because humans, we we evolved as a
00:52:49
scavenger species. We would engorgorge ourselves because we knew it wasn't happening every day.
00:52:54
>> Modern man is live is living in the feast every single day. And that's why we're are we have an out all the chronic
00:53:02
diseases. This is the red zone is the zone of risk for chronic diseases and cancer. And when you look at the obesity
00:53:11
epidemic, you look at all these things, these guys are and it's it's like we can
00:53:16
visit the red zone. We don't want to live in the red zone. >> So if I was to visit the red zone, it
00:53:22
would look like meeting high carbohydrate diets, lots of sugar. >> Yeah. No exercise.
00:53:28
>> No exercise. >> Yeah. And basically modern man. >> And also eating five meals a day, like
00:53:33
snacking all the time. >> Yeah. Oh, then you'd be, you know, we have uh there's document cases. We have
00:53:38
them up to 500. >> You can get GKIS of 500. >> You have people with, you know, blood
00:53:44
sugars about 4 or 500 milligram per deciliter. I mean, you could do the and zero ketones. I mean, you you do the you
00:53:51
do the math. It's it's unbelievable. >> You're basically saying, I want to keep my my blood glucose levels
00:53:55
>> and you want to you want to have some level of ketones >> and high and my ketone levels somewhat
00:53:59
as high as I can. >> Well, it's you don't want to go because people then have the physicians
00:54:03
listening. They go, "Oh, he's going to go with the keto acidosis." People give me a break. Keto acidosis is like when
00:54:09
you have ketone levels of 15 to 20 millmer. Are you kidding me? What is yours? 0.4. That's called nutritional
00:54:15
ketosis. That's how we evolved. When you have type 1 diabetes where you can't control sugar or or or insulin, you have
00:54:23
no insulin responsive. You're going to get high levels of sugar and ketones. This is this is a pathological
00:54:29
condition. Most of type two diabetes, these are all pathologies based on damaging oxidative phosphorilation. So
00:54:37
what this chart does is for the first time and we put it together because we did all the B in the paper discusses the
00:54:44
bioenergetics. What we're finding in cancer is that if you can get into the green zones where your blood sugar is
00:54:51
low and your ketones are elevated, you hammer the hell out of these tumor cells because they they they you're taking
00:54:58
away one of their two primary fuels driving disregulated cell growth. Okay? And as the and as the and as the ketones
00:55:08
go up, the rest of your cells in the body are getting super healthy. The tumor cells can't tap into the value of
00:55:16
a ketone because the organel needed in the tumor cell to do that is corrupted structurally and functionally is am I
00:55:26
clear about that? >> Yes. >> Okay. So ketones will make you healthy, the normal cells of your body, but
00:55:32
cannot be used to help the cancer cell because you need a good structural functional organel to burn them. So they
00:55:39
become marginalized and if the ketones go up, they're actually toxic to that to that cell to some extent. So but they're
00:55:47
still alive. Uh the cancer cells are now incapacitated. there. Uh we we showed you get rid of
00:55:54
the abnormal inflammation, you get rid of the angioen, the abnormal blood vessels. You're taking an angry tumor
00:56:00
and making it much less angry, much less inflamed, uh uh more indolent uh kind of
00:56:07
a tumor, but it's still there. It's not because the other fuel that's keeping this cancer cell going is the glutamine.
00:56:14
Okay. So now when you have the patient in this green zone, this is for management. Now, Stephen, this is
00:56:22
prevention is is never having to deal with what I'm talking about. If you're living in the yellow zone, the
00:56:28
probability of getting cancer or chronic diseases is already reduced. Okay? But now you have some poor guy out there.
00:56:37
He's living in the red zone his whole life. He wants to manage the cancer that he has. He he has to get down in the
00:56:42
green zone and try to stay there as long as he can. But the cancer will still grow because it has access to glutamine.
00:56:48
Okay? And glutamine is always here's the bloodstream. Look at look at you have this much blood. Cancer needs that. So
00:56:54
you always have a surfitit of glutamine. So you have to come in now with drugs and the drugs like repurposed drugs to
00:57:02
target the the glutaminolysis with this one here this BMC big paper here. >> Mhm.
00:57:08
>> Okay. This paper and the new one we have with the ketogenic for the high childhood um high-grade gloma for kids.
00:57:15
So once once you get down here, you come in with drugs that target glutamine. I've looked at one and that's Mbendazol.
00:57:24
Okay. How did I come to that realization? People knew that embendazol had some therapeutic benefit about
00:57:29
cancer, but they don't believe it until you show the mechanism. That paper shows
00:57:32
the mechanism. It targets glucose and glutamine. That was this one targets glucose and glutamine, the two fuels
00:57:38
driving the disregulated growth of the tumor. Okay. So here's the here's the mitochondria.
00:57:45
So it's getting the glucose and the cytoplasm from the sugar uh and making and it's fermenting that and then also
00:57:52
the the amino acid glutamine comes in. You have to block the glycolysis and the gluc these two pathways. You have to
00:57:59
restrict availability of glucose and glutamine together at the same time. Yeah. >> I speak only about things that I have
00:58:06
tested in my lab and published papers on like this. So you have to real the cancer field doesn't understand that the
00:58:14
cancer can't grow without glucose and glutamine and can't switch to fatty acids or ketone bodies.
00:58:21
>> That's still not going to kill the cancer though, is it? It's just going to >> Yeah, we don't ever use the term cure
00:58:25
because some of these tumors, now let me tell you, we have people like Pablo Kelly from Devon, England, he had the
00:58:31
glyobblasto uh he didn't take any radiation or chemo. He just did metabolic therapy. He
00:58:37
lived for 10 years. He was diagnosed with an inoperable glyopblast. They wanted to irdiate and poison him with
00:58:44
the drugs. He said no. He was one of these naturalistic kind of guys. And um he he lived for 10 years and the tumor
00:58:52
became operable. He had four debulking surgeries on an originally described inoperable cancer cut out four times
00:58:59
because once we put the metabolic therapy the circle the demarcation of the tumor. Whoa. A neurosurgeon says I
00:59:04
think I can get this out. But he never never got rid he lived with it for 10 years. Had a couple of kids. He died
00:59:10
from a cerebral hemorrhage on the last debulking surgery. He never died from the tumor.
00:59:13
>> But you're saying you're saying that the two work together in in tandem. You're
00:59:17
saying that the chemotherapy works in >> the Now that's where that's another thing. So what we do u this is very
00:59:24
interesting. So if you put the patient in nutritional ketosis, the the ketogenic
00:59:31
state of nutritional ketosis facilitates the delivery of drugs to the tumor cell.
00:59:37
It actually makes you can use lower doses of drugs and you and and and you get bigger effect. The therapeutic
00:59:44
benefit increases with lower dosing. >> So you want to be in ketosis when you do
00:59:48
these chemotherapy, radiation therapy. >> Yeah. And then you use much lower doses.
00:59:52
This is what we're doing in a stimul clinic. We're taking pancreatic cancers. These guys live in four and five years.
00:59:58
What are we doing? And advanced breast cancer and all these terminal cancers. We put them into some level of ketosis
01:00:04
and then you come in with the standard drugs, cis platin, carboplatin, whatever you want to do, but you cut the dosages
01:00:11
down big time and then they have tremend the the uh and this is what the title of
01:00:17
the paper is ketogenic diet uh as a metabolic vehicle uh for enhancing therapeutic efficacy.
01:00:28
The current body of research suggests that being in a state of ketosis can act as a helper therapy, enhancing the
01:00:33
cancer killing effects of chemotherapy while simultaneously protecting healthy cells.
01:00:36
>> Yeah. Yeah. Right. Right. >> Progressive oncologists are currently using ketogenic diets alongside standard
01:00:42
chemo to maximize its efficacy. >> That's right. That's what we're doing in Istanbul
01:00:49
and and and also in in in Greece. We're doing we're doing those same things. So you you can use this
01:00:55
>> when you enter a fasted or ketogenic state. Your healthy cells essentially go
01:00:58
into bunker mode. They slow their division, conserve energy, and build up their defenses. Cancer cells, however,
01:01:04
do not have this evolutionary off switch. They continue trying to rapidly divide. When the toxic chemotherapy
01:01:09
hits, your shielded healthy cells survive it much better. While the exposed rapidly dividing cancer cells
01:01:16
take the full hit. >> Yeah. >> Oh, okay. Interesting. >> Yeah. In other words, you make with the
01:01:22
tools you have work better. The problem in the field of cancer today is they're not using the tools in the correct way.
01:01:29
Now, let me give you another example. If you take imunotherapies, you hear about
01:01:33
these things, chimeic acid, G receptor, PDL, PD1, PDL1 inhibitors, they're called precision medicines, right? So
01:01:42
look, they're designed to attack a a molecule on the surface or stop that cell from uh being resistant.
01:01:51
>> Mhm. >> If you would try to attack and what they do often times, they come at after
01:01:55
you've failed chemo and radiation, they then come at you with an imunotherapy. The metabolic pressure shrinks down your
01:02:01
tumor, makes it very indolent, >> non-aggressive, and the rest of your body is healthy. You're not going bald.
01:02:06
You're not bleeding gums. Your microbiome isn't blown to hell. So, and then you can come in with lowdose chemo
01:02:13
imunotherapy because what'sever left in that remaining residual mass, they may all have something in common for having
01:02:20
survived all this, right? So now you can come in with a precision medicine and possibly resolution. I thought this was
01:02:27
fascinating. It says chemotherapy creates massive oxidative stress, i.e. damage inside the tumor. To repair the
01:02:32
damage and survive, the cancer cell requires massive amounts of glucose. So, if the patient is in ketosis, the
01:02:37
tumor's glucose supply is essentially cut off. It can't the cancer cell can't repair the DNA damage caused by your
01:02:43
chemo, leading to faster tumor death. Um, yeah, interesting. >> Well, don't forget also, listen to this,
01:02:51
and there's another thing people go in. What protects the tumor cell from chemo and radiation is the waste products of
01:02:58
fermentation. The lactic acid and the suxinic acid that are dumped out of this raging beast prevent these other
01:03:06
therapies from working. So if you want your therapy to work, you got to target those two fuels together at the same
01:03:13
time. And when you do that now this cell the shield is off. These things are super vulnerable to even low doses of
01:03:20
chemo and radiation. And the imunotherapies, look at if you have an imunotherapy, you try to attack the
01:03:27
beast when it's at its strongest. H you're not going to win. And this is what happens. You get only partial
01:03:32
response. They in the field of cancer today, they think living an extra six months is a major breakthrough. We're
01:03:37
talking about living an extra five and six years. This is what's really important. I just um I was reading some
01:03:43
research to figure out if oncologists so cancer doctors are currently recommending the ketogenic diet and it
01:03:50
says the vast majority of mainstream oncologists do not recommend the ketogenic diet to the to their newly
01:03:55
diagnosed patients. Um in fact if a patient brings it up many doctors will actively advise against it and the
01:04:02
reasons for that number one is the fear of cacettia. Cexia. Yeah. >> Cexia. Cancer. Cexia is a severe wasting
01:04:10
syndrome where patients rapidly lose muscle and fat. It is a massive problem and a leading cause of mortality in
01:04:15
cancer patients. Because the ketogenic diet suppresses appetite and often leads to weight loss. Encologists are
01:04:20
terrified that a strict keto diet will accelerate cexia and weaken the patient. >> Well, that's because they they have not
01:04:27
heard what I just said with respect to the biology and biochemistry. Okay. Cexia there's two ways you can lose in
01:04:34
cancer patients. CEXIA is the ability of the tumor cell to mobilize energy out of
01:04:39
the muscles. It's taking the glutamine out of your muscles and feeding. This is one of the two fuels that's driving the
01:04:45
beast is glutamine. Where are they getting the glutamine from? They're getting the glutamine not only from the
01:04:50
bloodstream, but they dissolve your muscles as a uh as part of that part of that process. So, when you put a patient
01:04:58
in nutritional ketosis, the weight loss is therapeutic weight loss. CEXIA is pathological weight loss.
01:05:05
Now, the only way you can lose weight is you take a high dose of chemotherapy. I travel all the time. So, I made a rule
01:05:12
in my life that I'll only travel with a cabin bag. The problem with this is there's not much space. And here's the
01:05:17
solution. It is called an extra 1% travel pack. And I teamed up with Extra to make this. Typically, I can only
01:05:24
bring some of my black shirts. And it's a trade-off of which black shirt should I bring? How many of these do you think
01:05:28
I can get in here? So, let's try 1 2 3 4 5 6 7 8 9 10 11 12 13 14. Let's try 15.
01:05:41
16 17 18 19 20 21 22 23 24. Okay, so that's 24 black t-shirts. Here's where the magic comes in. Zip it
01:05:51
up. Make sure it's nice and sealed. And then you use this little contraption. Stick it on there. I can now take more
01:05:57
than 20 black shirts with me, which will last me 3 weeks. So, if you travel frequently and you want to get one of
01:06:03
these so you can save more space and be away for longer, go to extra.com and use
01:06:07
code DOAC for 10% off our collection. And I think some of the background context here is that mainstream oncology
01:06:14
operates on the um sort of sematic mutation therapy, which is the belief that cancer is fundamentally a genetic
01:06:20
disease driven by DNA mutations. And because their training focuses on genetics, their treatments are designed
01:06:26
to target DNA and cell division like heradiation targeted genetic therapies rather than manipulating um cellular
01:06:33
metabolism. And lastly, as mentioned, I think we talked about this earlier, mainstream medicine requires massive
01:06:39
multic-enter double blind phase 3 clinical trials before a protocol becomes the standard of care. So dietary
01:06:45
interventions rarely get the level of funding. So on ancologists lack the institutional green light to prescribe
01:06:50
them to patients and they tend to say to them eat what you can. >> I I don't blame them. They're good. Many
01:06:56
of them are good people. The problem is the system doesn't train them to understand the biology and biochemistry
01:07:01
of the disease they're treating. Uh some of them become very resistant to this. They say get angry because if I why
01:07:06
didn't I why wasn't I told this? Well, first of all, they're not reading these papers. Uh you ask them about it. They I
01:07:12
never read it. Well, how are you going to know anything if you don't read the literature? Um, listen to this. The
01:07:17
National Cancer Institute, the NCI, on their website, on their website says cancer is a genetic disease caused by
01:07:23
what you just said. Okay, they I well I said why don't they put the articles in there showing all the tumors they can't
01:07:30
find any mutations. The somatic mutation theory says that cancer is caused by random genetic mutations. So now new
01:07:39
sequencing of normal people like you and me are finding mutations in all these driver genes in cells in our body that
01:07:46
aren't in disregulated cell growth. So we're calling them wild type cancers. What do you mean a wild type cancer?
01:07:51
>> You lost me. >> Okay. The nucleus of a tumor cell, a raging tumor cell. >> What's causing him that cell to grow? Is
01:07:58
it the mitochondria and the cytoplasm or is it the mutations in the nucleus? Okay. So according to the sematic
01:08:05
mutation theory, it's the mutations in the nucleus that are causing the disregulated cell growth. You take that
01:08:10
nucleus and put it into into a enucleated normal cell. >> Yeah. And there's no cancer.
01:08:16
>> No can there's no disregulation. >> There must be something else. >> Then you take the nucleus of the normal
01:08:21
cell and put it into the cytoplasm of a tumor cell and you get disregulated cell
01:08:27
growth. >> So it must be something other than the nucleus. >> Yes. The mitochondria.
01:08:30
>> Interesting. And it says >> so with mitochondria controlling our destiny and and and the the field of
01:08:36
cancer has yet to understand it, accept it, and then say, "Well, we can't do any
01:08:42
of this until we double the line crossover." That's just what do you mean? The science is telling us this.
01:08:46
That's your way of protecting a broken system. >> Are you pissed off about this? Cuz you
01:08:50
do seem pissed off about this. >> Well, who wouldn't be, Stephen? There's 1,700 people a day in this country dying from
01:09:00
cancer. I don't know the English. Listen, that that comes out to 70 an hour. And it gets worse every single
01:09:07
year. And the last time I was on the show, you guys use some old data. Look it up today. It's 2026. American Cancer
01:09:14
Society says this year in 2026 we will have 626,000 souls leave the planet from cancer.
01:09:25
Okay, this 2026 and every year it gets worse. So when you hear all the breakthroughs, we have we have
01:09:32
television ads in Boston for the cancer. Breakthrough after breakthrough after breakthrough. All these different they
01:09:40
come on and and and and all we do is get more dead cancer patients. Raise money for cancer. Where's the where's the
01:09:46
accountability for all the money you're raising? When are the work when is the people going to wake up? You don't make
01:09:51
someone healthy by irdiating and poisoning them. You've got to understand the biology and the biochemistry of the
01:09:58
disease. I have the concepts and the proofs, but the physician who works with the patient on a clinic basis, they're
01:10:05
the ones that must apply this to the clinic. So, there's two different things here. There's the hard science that's
01:10:10
the that's the bedrock for this and then there's the clinical person who has the
01:10:15
practice that practice does that. Together, you get great success or better I say success better than
01:10:20
anything that's out there today. The American Cancer Society recently released its latest projections for 25
01:10:26
and 26, and the data paints a fascinating dual-sided picture. More people are getting diagnosed with
01:10:31
cancer. Um, new cases. The ACS projects over 2.11 million new cancer diagnoses in 2026. This translates roughly to
01:10:41
5,800 new cases every single day. >> Approximately 626,000 Americans are expected to die from cancer in 2026.
01:10:50
>> Right. about 1,700 deaths per day. Lung cancer remains the leading cause of cancer death projected to cause more
01:10:57
fatalities than colurectal >> colurectal and pancre pancreatic cancers combined. I also just want wanted to
01:11:04
pick a point we were talking about earlier which is about the metabolic approach to cancers.
01:11:08
>> It says here and this is going to the point about you know people telling you
01:11:11
to just eat whatever you want while you're you know managing cancer. Um because the primary goal of the hospital
01:11:16
dietitian is to prevent weight loss during brutal chemotherapy regimes, patients are frequently told to eat
01:11:22
whatever they can and eat whatever they can keep down. It is incredibly common for cancer patients to be handed meal
01:11:27
replacement shakes which are often packed with corn syrups and refined sugars, ice cream, and high carbohydrate
01:11:32
comfort foods just to keep their calorific intake up. From a metabolic perspective, this is a tragedy. While it
01:11:40
keeps weight on the patient, it simultaneously floods the bloodstream with glucose and insulin directly
01:11:44
feeding the tumor. Um, and while keto is not the standard of care, the landscape
01:11:49
is beginning to slowly shift. There is a growing minority of integrative oncologists and specialized metabolic
01:11:56
clinicians worldwide that actively prescribe therapeutic ketosis alongside conventional treatments. Those doctors
01:12:03
use the keto diet and fasting protocols to protect healthy cells and um and and sanitize tumors before administering
01:12:09
lower more targeted doses of chemo. Yeah, that's what we developed. That's our that's our plan. That's that's what
01:12:14
we're doing. Okay. We we we do that because we understand the biology and biochemistry. And that's why we
01:12:20
developed we're developing the new society called more the more alliance metabolic oncology research and
01:12:27
education. This is bringing uh together what you just mentioned there in a logical approach to manage cancer. This
01:12:34
is a logical approach based on the hard science of decades of research initiated
01:12:40
originally by Otter Werberg and then continued by our group at Boston College. The American Cancer Society
01:12:46
says that breast cancer is increasing, prostate cancer is increasing, pancreatic cancer, melanoma, HPV
01:12:51
associated oral cancers are steadily increasing in the incidence of severe um cancers.
01:12:58
>> Yeah, there has been no major advance in managing glyopblast in 100 years. >> What's glyobblasto?
01:13:05
>> That's the the the deadly brain cancer. Okay, that killed uh Teddy Kennedy from
01:13:10
Massachusetts, Senator Kennedy, John McCain, President Biden's son, Bo Biden. It's killed a lot of various people and
01:13:18
it's considered a death sentence. No, no, no, no. We we we're keeping these guys alive. Okay, we're not saying we
01:13:23
cure the cancer, but we can certainly keep them alive a lot longer. Pancreatic cancer always considered so bad. We're
01:13:29
getting very excellent results in managing pancreatic cancer using metabolic therapies. We know what to do
01:13:35
and we know how to do it. I have clinicians that work with me, dieticians that know how to manage cancer
01:13:41
effectively. We can do it right now today. If someone were to say, Seaf Freed, get your get your group together.
01:13:48
Let me see what you can do. I will put up our metabolic therapy against any trial from any of these pharmaceutical
01:13:54
companies. We can keep these people alive a hell of a lot longer to participate in our society. We're not
01:13:59
doing that. >> If you were made president today, Thomas, >> of the United States,
01:14:03
>> of the United States, >> don't go there. I'm going to go there. >> Those guys are
01:14:12
uh not, let's put it this way, they're not scientifically literate. >> But I would have to be. Yeah. Right.
01:14:17
>> You, Professor Thomas, you're now president of the United States, and your primary objective is to bring down this
01:14:25
1,700 Americans that are going to get cancer a day. >> Um, is it is it get cancer or die from
01:14:32
cancer? >> No, they die from cancer. Okay. 1,700 a day dying from cancer in the United 70
01:14:37
an hour. Think about it. >> You you can put in place policies to stop this happening and to also help
01:14:43
people manage it better. What is it you do? >> First of all, we wouldn't throw out
01:14:46
everything. Just like I said, we have a strategy now to manage cancer effectively.
01:14:51
>> Okay. So, you we're not going to get rid of the drugs that are making billions
01:14:55
and billions of dollars. We're just going to use them at lower dosages in a different different
01:14:59
>> But we also want to prevent it in the first place. Well, preventing it that comes back to our chart.
01:15:03
>> I'm going to write down the manifesto. So, what what is what do we do to prevent these 71 people an hour dying of
01:15:08
cancer? >> Well, that has to come from government policies. >> Okay. You just got promotion. You're now
01:15:12
the king of the United States. So, you don't even need to ask anybody. >> What do you do to prevent the 71 people
01:15:17
a day dying of cancer? >> It's going to be education. >> Education number one. >> Education number one.
01:15:23
>> Okay. >> You have to let people know that those. And now let me tell you another thing
01:15:28
that's really important. It should not be any government or government official telling anyone what
01:15:36
they should or should not eat. Okay? The the power of this chart is um personal.
01:15:43
You're embolding the patient. They have to know. We're not going to tell somebody, "Oh, if you continue to eat
01:15:51
bad food, you're going to have you're at high risk." And that person, I don't care. I'll smoke cigarettes and I'm
01:15:56
going to Well, the government's not going to come into this guy's house and take away the bad food. No, no, no, no.
01:16:00
That should never happen. Those foods are there because they give us pleasure, but they should be the the knowledgeable
01:16:07
person would be to say, I'd like to have it every now and then, but I can't live
01:16:12
in that environment. And the other thing we do terribly in this country, the poor
01:16:16
people in these food deserts where you only get crap food and and as a tragedy in itself there they to go to whole uh
01:16:25
whole foods where they have the expensive ribe eyes and all this stuff that's much more expensive. A lot of
01:16:30
people can't afford the kinds of foods that will put them in these better healthy zones.
01:16:35
>> So we're going to make food healthy food more cost cost effective cheaper. Those
01:16:40
are easy words to say, but in practicality it's not. >> Now, what kinds of foods should people
01:16:45
be eating? >> Well, I I think they should just try to avoid the highly processed carbs. Okay.
01:16:49
You don't listen to this. You and and exercise. There's a lot of things we can do that would mitigate the the
01:16:59
inflammatory conditions put on this chart. The goal here is we know what keeps us healthy. It's the efficiency of
01:17:06
that organel. We want to do everything possible to keep that organel healthy. We will reduce dementia. We will reduce
01:17:14
diabetes. We will reduce obesity. And they say, "Well, GLP, why don't I why don't do and human beings are are the
01:17:21
kind that I want a quick fix for everything?" Right? >> Ampeg. How about some ampeg?
01:17:25
>> Is this what is this GLP? >> GLP1. >> Okay. We don't, you know, first of all,
01:17:31
we haven't done any research yet to know where a GLP would put you on the chart.
01:17:36
We do know one thing. It lowers blood sugar. How level how high of a level would it bring to ketone? Because it's
01:17:42
the ketones that keep the organel healthy. So, I'm lowering blood sugar, but am I raising the ketones that
01:17:48
enhance the bioenergetic efficiency of the organel? I don't know what number and hasn't been done yet. I don't I
01:17:54
haven't seen any papers coming out. >> Okay. So, we'll keep the zen peek off the table, but you're saying exercise
01:17:59
number three. So, I've got I've got education, kill the food deserts so people can get
01:18:04
healthy food. >> Yeah. Um, stay away from the ultra processed stuff. Number three, exercise.
01:18:08
We're going to give everybody free gym memberships and whatever else they need. >> Reduce stress, emotional stress. You got
01:18:12
to you got to do that. And there's a lot of ways. Music therapy. There's a lot of
01:18:15
different ways you can meditation, >> friends, happiness, all of those reduce stress. So, I had I had a guy from uh
01:18:22
Korea. I think it was Japan or Korea. We did a big meeting one time and he he didn't
01:18:28
tell me what to do. He says, "Um, you want to get cancer? If your job and if your goal in life is to get cancer, you
01:18:34
got to eat crap food all the time, you have to have terrible sleep, make sure you never unass the couch, sit in front
01:18:41
of the TV all day, look at doom scrolling, do all that kind of stuff. Make sure you never exercise, and make
01:18:47
sure you don't have any friends or be happy. He says, you're on a fast track for for not only cancer, but all these
01:18:54
other chronic diseases. So, so that's the what I just said is you need to not do that.
01:19:00
you're doing a great job. You know, there's not many people are going to be measuring their GKI every day, but there
01:19:06
are people who love to measure that kind of stuff. Um, now I tell you another thing. So, they put these things on your
01:19:12
arm, these continuous sugar monitors. They're making continuous glucose ketone monitors. So, apps are coming out now.
01:19:18
Believe me, there's apps. I have my Lucas Lou and some others are making these apps in my lab. and and um you can
01:19:25
take your cell phone and and photograph a particular food item and and the food item immediate you put
01:19:35
places you're put the food item on the chart so you'll know eating that will give you what zone you'll be in if you
01:19:40
eat it. So um it's really interesting and and these things are coming. We're using AI to so but it's purely patient
01:19:48
empowerment. Okay. The patient themselves, the person themselves make the choices. No government president or
01:19:57
king or whatever you want to say should ever tell people what and how they should eat. The patients should be
01:20:03
familiar with this and have the knowledge to know I'm going to test what I think. So people say to me all the
01:20:09
time, "Well, just tell us what you can eat." That's all they say to me. Okay, eat whatever you want. You figure out
01:20:16
where on the chart you're going to be and then you'll know. So people say, "Well, I can't eat ketogenic diet."
01:20:20
Well, our our group in in Greece, now you tell me. They got the brain cancer tremendous success in keeping brain
01:20:26
glyopblastoma guys alive. What was the diet? It was a calorierestricted Mediterranean diet. salmon,
01:20:33
sardines, olive oil, avocado, and exercise. That is that like oh man, that that's the
01:20:41
worst diet. What about the carnivore diet? What about the the ribeye with a little sauce bernese on top of it? This
01:20:47
keeps your your blood sugar low and elevates your ketone. If you want to do it with plants,
01:20:53
everything you got fish, plants, you get the vegans and all these kind of people.
01:20:58
This is a bioenergetic road map to health. >> Let me just give some specific. So this
01:21:03
is amazing. What about high fructose corn syrups and refined? >> Oh man, that's the worst kind of crap.
01:21:07
You don't take that. >> What about What about industrial seed oils? >> Well, you know, people talk about seed
01:21:12
oils, >> canola and soybeans. >> I DON'T KNOW. BUT every there's another thing too.
01:21:18
You and I are different. Uh we have an individual metabolism. uh age, race, sex, all all the religion,
01:21:26
all kinds of stuff determine what and how you live. And I can't be sure uh what you eat and what I eat or what you
01:21:34
exercise where it's going to put put us on the chart. >> Synthetic pesticides. I was reading here
01:21:38
that it's in increases the chance of lymphoma by a staggering 41%. >> They all damage the oxidative
01:21:44
phosphorilation, putting the cell at risk for compensatory fermentation, disregulated cell growth. Wow. The
01:21:50
problem, the problem. The field doesn't understand what I'm saying with respect to the origin of cancer, how it happens
01:21:57
mechanistically, how this organel controls the life of the cell. They don't know enough about the biology and
01:22:05
biochemistry of the mitochondria. You ought to get guys on here like Nick Lane, he he from England. I mean, these
01:22:10
guys like Doug Wallace and some of these guys, they're mitochondrial biologists.
01:22:15
They they they understand this kind of stuff. I want to give people actionable things that they can think about. So, um
01:22:20
that's why I was asking you this question about you becoming king. Fasting protocols.
01:22:25
>> Well, intermittent fasting. >> Let me let me talk about that just briefly. Do you ever try it?
01:22:30
>> Yeah. >> What do you think? You liked it? >> It depends how long you're talking
01:22:34
about. >> Okay, let's go a week. >> Oh, I know. I've not fasted for a week before.
01:22:38
>> Okay. You know what is the call the wall? This guy, he just sent me his book. It's coming out. Very nice guy.
01:22:42
Veral Simck. He say people share things with me. The wall is after about three days of not eating, just drinking water,
01:22:52
you hit this wall and it's like, "Oh man, I'm just I can't deal with it anymore. It's just a terrible feeling in
01:22:58
my body. I can't sleep at night. I got the Jimmy legs. I got all kinds of problems. Screw it. I'm not doing this."
01:23:03
He found out if you sip just tiny amounts of a grape juice, you can get get through the wall. What we do for the
01:23:08
cancer patients in the way we design our clinical procedures with my clinical friends, we do a zero carb diet for
01:23:16
about a week uh while the body is readjusting getting getting bringing them out of the red zone getting into
01:23:21
the yellow zone. You can't believe the power of glucose as an addictive drug on the brain. It's unbelievable. It's like
01:23:28
cocaine. It it's it's and you know that when you start you start shaking and you
01:23:32
go. So, but if you don't eat carbs and just eat meat or whatever to keep you in a low GKI, um then when you jump off to
01:23:40
the water only fasting, it's much less traumatic to the brain. You've gone through the wall of the gate, so to
01:23:44
speak. So, once you know how to get through the gate, you make this whole process a lot a lot easier. And that
01:23:50
helps people enormously, especially those people that want to get rid of their chronic disease. Okay? Because or
01:23:57
some, you know, we have a lot of people out there that just like to do all this stuff. You know, you got these these
01:24:02
people that go overboard on everything. But, you know, right now we have an obesity, chronic epid cancer epidemic.
01:24:09
All of these epidemics are the result of an abuse of that organel in one way or another. And we have a pl a plan to
01:24:16
mitigate that abuse and at least people have an at least they're empowered to do
01:24:20
it with the help of knowledgeable physicians. >> I want to just keep on this point of
01:24:24
actionable feedback. So, um Dr. Valter Longos Dr. His extensive research clinical trials prove that fasting
01:24:30
mimicking diets drastically lower IGF-1 which triggers cellular autophagy and actually makes standard cancer therapies
01:24:37
up to three times more effective by removing the metabolic shield of cancer cells.
01:24:42
>> Yeah. Which is the gluc the waste products of of of gluc which is the lactic acid and the suxenic acid that
01:24:48
all goes down. >> Would you recommend again if you're king would you recommend that
01:24:52
>> I would never recommend any I have to just give them the knowledge. Then the person has to make the decision
01:24:57
themselves. >> Do you think it could be beneficial? >> Of course, >> if you were king to um have everybody
01:25:02
wear a CGM, one of those continuous glucose monitors, at least once. >> No. >> Never.
01:25:08
>> No. I I think if you have cancer and you really want to stay in this green zone
01:25:12
to know, right? Listen, I was down in Mexico not long ago. I was talking to one of the head physicians down there.
01:25:18
He wore one of these things, right? >> He said, "Every time I wanted to go out and have a party, have a good time, this
01:25:23
damn thing would be beeping." So what do you ripped it off and threw it in the trash? So that you don't want somebody
01:25:29
barking in your ear when you're having a good time. That's why what you're doing
01:25:33
right now with this, you're choosing to prick your finger. >> You're the one making that decision.
01:25:38
There's not something on your arm saying, "Stephen, don't do that. Don't do that."
01:25:42
>> But you know what? It was useful to wear it once or twice because it even I could
01:25:46
I suddenly realized that things I put in my mouth >> had an impact on my blood sugar and my
01:25:51
blood which and also I realized that it had an impact in 10 minutes. >> Yeah. >> And I thought and then and then also
01:25:57
when my blood sugar came back down and crashed >> I thought oh gosh I feel >> I could suddenly pair my behavior to my
01:26:04
feelings. >> Yes. Well, that that now I'm not I I no I I' I've seen that. And not only that,
01:26:10
uh Andrew Scarboro from England who who has been doing this for for the stage three go uh he's like 15 years out. He's
01:26:18
done this so many times with the finger prick and all this. He knows now already
01:26:22
when his body is in these zones from the feeling that you just described. But for
01:26:27
the people at the beginning and who are given a terminal diagnosis, they want to
01:26:31
get into these green zones and they want to use the things that are going to keep
01:26:34
them alive on the planet for a longer period of time with a higher quality of life. That is important. That thing on
01:26:41
your arm can help you stay in that zone until you have this thing managed at which time you can choose when to do
01:26:48
that. So there's flexibility in this whole process. It's not one like for example we have the standard of care
01:26:54
which is written in granite for crying out loud. They get all they they if you do anything different from the standard
01:26:59
of care you could lose your license as a physician. Metabolic therapy is is patient driven. It's driven on the
01:27:06
patient. >> What about hyperbaric oxygen? Yeah. There was a study in 2013 that demonstrated that while the ketogenic
01:27:12
diet alone significantly slowed tumor growth in systemic metastic cancer mouse models, combining the diet with
01:27:18
hyperbaric oxygen therapy elicited a profound synergetic decrease in tumor growth and drastically increase survival
01:27:24
times. >> Yeah, we published that paper with Dominic D. Augustino. So we we put my So
01:27:29
uh listen, hyperbaric oxygen will create oxidative stress in cells that do not have efficient oxidative
01:27:36
phosphorilation. uh cancer cells. >> Cancer cells. So you can kill cancer cells by oxidative stress by irdiating
01:27:42
or poisoning them or you can put a patient in in nutritional ketosis and then put them in hyperbaric oxygen and
01:27:49
the cancer cells are selectively killed. When you irdiate somebody, you're damaging the whole body with all kinds
01:27:55
of stuff. And there's another thing, Stephen, you got to listen to this and you listen carefully. when you go to
01:28:00
these treat these standard of care >> standard when you use standard of care radiation chemo whatever they give
01:28:07
imunotherapies or whatever so the patient comes in and he says I've been really working hard on this the doctor
01:28:12
says oh no that doesn't work right gives you some radiation or gives you flying up into the red zone the treatment
01:28:18
itself puts so much stress on the body that the body itself starts going you go into the red zone from the very
01:28:24
treatments that you're giving to the patient which is making strengthening the tumor else.
01:28:30
>> You're not against chemotherapy, though. Are you? >> No. I'm I'm I'm positive about it, but
01:28:34
it has to be used in the right context. >> It has to be used when your body is in
01:28:40
this state of nutrition. And you can use low doses so you don't force the tumor cell to become even more resistant to
01:28:47
the treatment. >> The next thing which is actionable is what you talked about earlier, which is
01:28:52
these microplastics and forever chemicals. In late 2023, the International Agency of Research on
01:28:56
Cancer officially upgraded these forever chemicals which are used in non-stick pans and food packaging to a grade one
01:29:03
carcinogen >> in humans, cancer causing in humans based on strong mechanistic evidence
01:29:08
that it induces epigenetic which is gene alterations and suppresses the immune system. So you ban the forever
01:29:15
chemicals. >> Okay, this is a beautiful paper. I went back and I took what all of Otto Werberg
01:29:21
meticulously went through all of his work showed where he was absolutely correct and where he just didn't have
01:29:26
the the new information that would make him I talked about the forever chemicals
01:29:30
microplastics guess what they damage the organel they get into they break they cause rosin damage they it reduce the
01:29:39
efficiency of oxidative phosphorilation causing a compensatory increase in the utilization of glucose and glutamine and
01:29:47
disregul related cell growth. Everything comes back to this organel. Chron all chronic diseases and cancer are the
01:29:53
result of damage to this organel. That's why having this little thing here is so
01:29:58
important. It's a great prop. I got to get one for my class. >> You can keep it. Um the next thing is
01:30:05
purifying the water supply. Um heavy metals are found in local water supplies to run off and ultimately are
01:30:11
carcinogenic in some cases. The IARC classifies arsenic and cacadium as group one on carctogenics and they're
01:30:20
frequently found in unfiltered public water infrastructure. So you clean out the water supply as well.
01:30:26
>> Yeah. >> You know all this stuff is coming into our water supplies. People flushing down
01:30:31
all these chemicals into the into the which then leech back into the water supply. And every one of the chemicals
01:30:37
that we have looked at that has been linked to oncology or disregulated cell growth all damage the oxidative
01:30:43
phosphorilation chronically. So we're bringing the entire focus back to things what can I do to keep this organel
01:30:52
healthy uh even if I'm exposed to these chemicals if I can do get into these zones like you're trying to do. So even
01:31:00
if you are exposed to these, this organel has an incredible healing power in itself.
01:31:06
>> What is the most important thing we haven't talked about that we should have talked about, Professor Thomas?
01:31:09
>> Well, I mean, you've covered a lot. One of the things I I want to talk about uh
01:31:13
is metastasis. >> What's that? >> That's the spread of the tumor throughout the body.
01:31:18
>> Okay. So if you were to have a cancer that's just localized in one spot, >> you know, the probability of developing
01:31:25
a therapy that would be um long term is highly increased. The problem that kills
01:31:32
people is the spread. So if the tumor is in the breast and it spreads to the liver and the lungs and the brain, you
01:31:38
know, you've got a problem. Lung cancer spreads to the brain, the liver. Most of
01:31:42
these cancers that spread to the brain or other organs become difficult and that's why you use systemic chemotherapy
01:31:49
you're trying to stop. What we have found is that you have a a stem cell people love stem cells. If you ever hear
01:31:57
the term stem cell tumor wow stem cell tumor stem cell tumors cannot metastasize how do I know because I have
01:32:03
stem cell tumors diagnosed as stem cell tumors with stem cell markers. I've grown them. They grow very angry. They
01:32:09
get a lot of blood vessels, but they can't spread. Okay, how do you get spreading tumor cells in your body? The
01:32:16
immune system comes in, recognizes that as an unhealed wound, and then fuses with the stem cells, and then you have
01:32:23
these hybrid cells. They are programmed to move around your body. So, they are a
01:32:29
macroofagage tumor cell hybrid. So, and they're very hard to kill, but we found they're remarkably sensitive. They're
01:32:37
glutamine driven. So we know they're glutamine driven and they need the glucose and that why that's why
01:32:44
metabolic therapy done the right way can nail nail those metastatic cancer cells
01:32:50
purging them with a little little bit of imunotherapy to go along with it. You might be able to to get what we call
01:32:56
resolution. Don't forget my colleagues and I do Diagto Joe Maroon we built the press pulse therapeutic strategy. I
01:33:03
mentioned that on your previous show. That's the way you you you press down the glucose of the tumor and then you
01:33:10
pulse to kill the glutamine which will which will target the metastatic cancer cells enhancing the health and vitality
01:33:16
of the organs already infiltrated by the tumor. >> I looked on our previous conversation
01:33:20
doc professor Thomas and um it's quite heartbreaking because the comments sections are all people that are e
01:33:27
either struggling themselves with cancer or a loved one of theirs their wife their husband has just been diagnosed
01:33:33
with cancer. Is there anything for those people that have clicked on this video because I imagine they are in the
01:33:38
millions. >> Yeah. >> That you want them to hear. >> Well, the thing of it is is why Well,
01:33:44
this is a bigger issue. When you have the science and you have the strategy to manage cancer effectively with minimal
01:33:51
toxicity, not to say we can cure, but to say we can manage it. Why is it not being done?
01:33:57
That's the question. But to them to them who've tuned in. >> Okay. So these kinds of conversations
01:34:04
that we have are allowing the populations to realize that there is their loved ones do not need to be
01:34:14
sacrificed for the good of industries that are generally considered profitable. They in
01:34:22
other words the profitability of the industries are based on your sickness. Uh and and a lot of those comments came,
01:34:30
oh, you can't you can't do anything. Yes, you can do something about it. When you're armed with the knowledge and
01:34:36
people ignore the knowledge, then there's a problem. >> Do people need to sort of self advocate
01:34:40
to some degree? >> I think so. >> With with uh care providers, what do they >> Yeah. I I think that's a very delicate
01:34:47
question. >> Yeah. >> That the oncologists never heard of this stuff. >> They have never read these papers. They
01:34:52
were never trained in medical school to know the biology and biochemistry of cancer. It was told to be a genetic
01:34:58
disease. Theories are so important in science. For 1,800 years, people thought the work of Aristotle, his comments and
01:35:07
the mathematics of Claudius Talami said that the earth was the center of the solar system and all the planets uh and
01:35:16
sun revolved around the earth. The geocentric theory, right? Capernicus struggled with the talami mathematics
01:35:23
and realized that if he put the the sun in the center of the solar system and made earth just another planet, a lot of
01:35:30
the mathematics made sense. Kepler comes in and says these aren't circles, they're ellipticals. Galileo takes the
01:35:36
telescope, sees the moon's interpreter and was able to look at and quantify where where predict where planets would
01:35:42
be at a certain period of time. Then they took poor Gillodono Bruno. You know about this guy Bruno? Oh, there Steven.
01:35:49
You got to know Bruno. Your job is to know about the poor Bruno who was burned alive by the Catholic Church for
01:35:54
challenging the the the geocentric theory. And he became a martyr of science. So when you have established
01:36:01
power structure, whether it's a religion or whether it's an industry or whatever,
01:36:06
challenging that can be very very hazardous. >> Has it been hazardous for you? >> Listen, no. I mean, I do what I do
01:36:13
because I like I just collect more and more data to support. Hazardous for me would be getting blindsided. Blindsided
01:36:19
would be somebody coming at me with a piece of new data that I have never considered. I don't sleep. I I think
01:36:25
about this stuff all the time to avoid the blind side. My students are on the on the alert for any paper that comes
01:36:31
out that says cancer oh cancer cells can burn fatty acids and ketone bodies. Oh,
01:36:35
really? Let's go back through and dissect out their control experiments and you find in every case there was
01:36:41
always some glucose and glutamine in the media making it look like the fatty acids. So, so that's what bothers me.
01:36:47
What bothers me is getting hit with a piece of data that undermines what we're what we our knowledge base is. And so
01:36:54
far we haven't had that. Okay, it's we're standing on the shoulders of Otto Warberg, a giant in the field of
01:37:00
biochemistry. He was thrown under the bus when everybody thought cancer was a genetic disease. My this paper goes back
01:37:06
and shows exactly where Warberg made his mistakes and where we have rectified some of that. Bringing the whole field
01:37:11
back on where it should be. It is a mitochondrial metabolic disorder and we can account for all of the phenotypes
01:37:18
and characteristics of that disease knowing that now with that knowledge logical people and people interested in
01:37:25
helping others will will uh take advantage of that. We're not throwing out all these toxic chemicals. We're
01:37:32
learning how to use them in a different way and that's where the success is going to come. So let's con let's
01:37:37
conclude with a a actionable takeaway for people who are suffering themselves with with cancers um or have someone in
01:37:44
their family right now that is suffering from cancers. What is the actionable takeway?
01:37:49
>> Well, I think the action will take once this paper comes out they can start taking action if they are motivated
01:37:53
enough. >> They can read about this. they can read about it and then try to like just like
01:37:58
you're doing no different >> get into these zones and then work with their oncologists, knowledgeable people
01:38:05
to to to treat them with standards of care. Yeah. As long as they can remain and then we do non-invasive imaging, PET
01:38:13
scans, see MRIs. >> Okay. So, specifically what what you're saying is this paper, I will link it
01:38:18
below in the comment section for anyone that wants to read it. This graph will be on the screen throughout this episode
01:38:22
anyway, so people can screenshot it if they want to have a look. And the way that they test whe what what their GKI
01:38:28
index is is they can buy one of these Keto Mojo things which you can get on Amazon for $ 20 $30.
01:38:33
>> You prick your finger. It gives you the glucose reading. Yeah. >> You divide it by 18.
01:38:38
>> No, no. The new machines have the button. You So even the people only have to do that.
01:38:42
>> Okay. Fine. And as you can see on here, this is an interesting way to sort of
01:38:48
increase your your management improve your management of of some of these. >> Yeah. And then there's a challenge
01:38:55
to get into those zones. Um, you know, I'm not saying this is easy stuff. GLP1 inhibitor, man, that's a hell of a
01:39:03
lot easier than than than doing this. >> And I should probably say always consult
01:39:08
with a medical professional. >> Yeah. Um, I I think uh because you know, a lot of people they have a lot of
01:39:14
coorbidities. They have diabetes, high blood pressure, hypertension, cancer. They have a it's not a perfectly healthy
01:39:21
person with cancer. >> Mhm. So before you go in to challenge that, you need to have what you look
01:39:26
like you you might look, you know, you might have to be adjusted in some way. That's why the people who the physicians
01:39:32
that are working with this can do all that. I I'm I'm not in the clinical thing.
01:39:36
>> And there are some people who respond poorly to the ketogenic diet is high states of ketosis because I've I've
01:39:41
received DMs before from a woman who said, "My my husband did ketosis and he collapsed unconscious. He took him to
01:39:47
the hospital. He had some coorbidity." >> Yeah. Yeah. Yeah. Oh, the other thing too is you got to be some people have
01:39:52
carnitine deficiencies. Carnitine prevents fatty acids from being made into ketone bodies.
01:39:57
>> So, so, so they can be carnitine supplementation can help them, but you need a physician to know this.
01:40:04
>> We have a closing tradition where the last leader question for the next and a
01:40:07
question left for you is on the subject of energy. What in your life has brought
01:40:10
you the most energy and what was the biggest energy drain you've ever experienced? Well, this is bringing me
01:40:18
the biggest energy. This >> well not this the whole concept. The idea that you have found
01:40:27
uh mother nature has allowed you to look into the depths of of of what we consider the biology and biochemistry of
01:40:36
how bodies work. and knowing how to take that and apply it to people that are suffering from all these different
01:40:43
chronic diseases and giving them the opportunity to change that because before that it was mysterious. Oh, I'm
01:40:51
do I'm in keto. What's your GK? I I don't know. Well, now you have a quantitative opportunity that gets us.
01:40:58
So, we have a lot of evidence. I think people should be feel encouraged. I think we have given hope to the hopeless
01:41:06
and and I think that's empowering and the goal here is not to make a billion dollars. It's just to know that you've
01:41:12
kept all these poor souls alive longer than they were projected to be to be. And I think this power and that keeps us
01:41:18
going because when we see more and more people coming to me, I get emails back from people three or four years ago and
01:41:23
I said, "Gee, I thought you were a goner." And he says, "I'm doing really well. Just came back from a vacation
01:41:28
with my wife." Well, that's empowering. I said, "Well, that's good. And don't forget, Stephen, all of our research
01:41:34
money comes from private foundations and philanthropy. >> So, >> so is that a way that people can help?
01:41:39
>> Yeah. >> And where do they go to help? >> Oh, Travis Kristopherson's foundation.
01:41:43
So, we in my papers that we have the foundations that support our work, private foundations. So, I'll link
01:41:49
>> and there are occasionally, yes, please link. There are occasionally people I
01:41:53
know and I when I give kits of information to people uh I say please consider making a donation only if it
01:42:00
works for you. Yeah. Don't charge them anything or ask them to pay something if it's not going to help them. If you were
01:42:07
told to be dead in 6 months and six years later you're alive. Maybe you throw us a few shekels into the private
01:42:13
found into the foundation supporting our work. >> I'll link that foundation below in the
01:42:17
comments section. Yeah, we have a couple on breast cancer on on on general general uh um support on the metabolic
01:42:23
approach that we have. So, we have a lot going. We're very excited. You can see all the papers we've published. Uh and
01:42:29
it's not like um uh some of these are in top journals, some of them are in new journals, but but the issue is we're
01:42:36
we're we're we're publishing this. >> My thing is, you know, I great great great respect for science and doctors in
01:42:43
the medical profession. Go go go get your information. Speak to your medical provider. There's so many tools out
01:42:47
there now. Go and check for yourself. >> Yeah. Well, I think in the oncology field, that's where we have this vast
01:42:51
wasteland of misinformation or misunderstanding, let's put it that way. They don't understand these concepts
01:42:57
where, you know, people who have done heart work and bone work and replacements, those people are at the
01:43:01
state-of-the-art with this kind of stuff. >> Well, the last conversation we had, it's
01:43:04
reached about 15 million people. So, on YouTube, it's got 10 million views and then across audio platforms, it's got
01:43:09
another five or so million views. Yeah. >> practitioner about, but also it actually
01:43:25
just creates a community of people in the comment section where, you know, this is a community of people that are
01:43:29
searching for hope. >> Yeah. >> And as some of them read through the comment sections, they actually
01:43:33
commented saying, "It was so nice to to speak to other people in the comment sections about what I'm going through
01:43:38
and how it feels from an emotional level." So, this is something I actually wanted to say in this episode was if
01:43:42
you're if you're listening to this conversation now and you've gotten to this point, do feel free to go into the
01:43:47
comment section and just offer some support and some love to other people um who are struggling because you know it
01:43:54
can be a very lonely experience the minute you find out you've got a diagnosis and off you go into the
01:43:58
internet into podcasts into AI to try and figure out what you can do. So, yeah, do share things that have helped
01:44:03
you point at different resources that are rigorous and offer emotional support to those that are in the comments
01:44:08
section. and that would be a wonderful thing. Thomas, thank you so much for all that you do. Um, you're you're an
01:44:14
absolute worrier for pushing science, the science into the world and for fighting for these people that don't
01:44:20
have the tools. And if you I mean, I don't think I've ever seen a comment section quite like it in terms of the
01:44:25
gratitude that people have for the work that you're doing. It is remarkable work. Long may you continue to do it.
01:44:29
>> Well, thank you very much. and you you know you play a very important part on
01:44:32
this because this information is not disseminated to the the population and it's the population of people that will
01:44:39
eventually make the change. So they're going to want this especially when we keep publishing more and more case
01:44:44
reports of successful cases and the ch the system will change and we just have to modify what we have to make it better
01:44:51
and I think that's what keeps us going. So I have no plans of stopping this anytime soon. My students are all
01:44:57
excited about this. they they're learning about it at Boston College. So, this is a big emphasis that we have and
01:45:03
we continue to do it. Again, scientific literacy is so important uh for uh how you um navigate through life and um
01:45:13
thank you very much for your show and we'll we'll keep uh pushing this as as hard as we can.
01:45:18
>> Thank you. YouTube have this new crazy algorithm where they know exactly what
01:45:22
video you would like to watch next based on AI and all of your viewing behavior.
01:45:26
And the algorithm says that this video is the perfect video for you. It's different for everybody looking right
01:45:32
now.