00:00:00
This may be the most controversial thing
00:00:03
we have on this table. This is a peptide
00:00:05
that absolutely torches belly fat at a
00:00:07
disproportionate rate. And what we found
00:00:09
is not only do patients lose an
00:00:11
incredible amount of weight, but they
00:00:12
also get the best improvements we've
00:00:14
ever seen in their liver health. It's
00:00:16
absolutely wild. And I think this is
00:00:18
going to be a trillion dollar drug when
00:00:20
it comes out. And I brought you here
00:00:22
because you're an expert on this subject
00:00:23
matter. And it's worth saying that there
00:00:24
was some significant news about this.
00:00:26
>> Correct. from the FDA saying that in
00:00:28
July they are going to consider
00:00:30
legalizing seven peptides and by
00:00:32
pharma's estimate it might be the most
00:00:34
dangerous thing to their entire business
00:00:35
model.
00:00:36
>> So do you think it is plausible that big
00:00:39
farmer didn't want these in the hands of
00:00:41
regular people because they can't patent
00:00:42
this and it's powerful
00:00:44
>> 110%. Because the question isn't what
00:00:46
can peptides do, it's what can't they do
00:00:49
and we've got several peptides here in
00:00:50
front of us and I want to go through all
00:00:52
of them.
00:00:52
>> Let's do it. So, this is probably the
00:00:55
most well-known peptide for skin
00:00:57
complexion and it improves quality of
00:00:59
hair and nails. And then epialon is
00:01:01
maybe maybe not going to be the fountain
00:01:03
of youth, but I'm very skeptical as far
00:01:05
as that goes. Next, we've got this. And
00:01:07
if you injected that at night, it would
00:01:09
improve your quality of your sleep.
00:01:10
Next, melan too. And this will actually
00:01:12
end up giving you a deep tan in response
00:01:15
to just a little bit of UV sun exposure.
00:01:17
It'll also give you some of the most
00:01:18
impressive erections you've ever had in
00:01:20
your life. So, be warned. And what else
00:01:21
have we got? Oh my gosh. There's
00:01:23
methyline blue where people take it and
00:01:24
they think it's going to make them live
00:01:25
forever. Don't take this. It literally
00:01:27
will stain your nails blue and your hair
00:01:28
blue. These two here stimulates building
00:01:30
muscle. This one can aid with healing
00:01:32
after an injury. And then is this this?
00:01:35
This this. It's crazy. It's wild.
00:01:37
>> So why don't I take it?
00:01:38
>> Well, we need to talk about that because
00:01:40
there are trade-offs.
00:01:41
>> But also outside of the world of
00:01:42
peptides for a second. I've got these
00:01:44
three vials. Do you know what those are?
00:01:45
>> Yeah. This is unfortunately our future
00:01:48
if we're not careful.
00:01:49
>> Explain. So, what we've got here is
00:01:50
representing the fertility trajectory
00:01:53
for young men. And I'm so scared.
00:01:58
This is super interesting to me. My team
00:01:59
given me this report to show me how many
00:02:01
of you that watch this show subscribe.
00:02:02
And some of you have told us according
00:02:04
to this that you are unsubscribed from
00:02:06
the channel randomly. So, favor to ask
00:02:08
all of you, please could you check right
00:02:09
now if you've hit the subscribe button
00:02:11
if you are a regular viewer of the show
00:02:12
and you like what we do here. We're
00:02:13
approaching quite a significant landmark
00:02:15
on this show in terms of a subscriber
00:02:17
number. So, if there was one simple free
00:02:19
thing that you could do to help us, my
00:02:21
team, everyone here, to keep this show
00:02:23
free, to keep it improving year over
00:02:25
year and week over week, it is just to
00:02:27
hit that subscribe button and to double
00:02:28
check if you've hit it. Only thing I'll
00:02:29
ever ask of you. Do we have a deal? If
00:02:32
you do it, I'll tell you what I'll do.
00:02:33
I'll make sure every single week, every
00:02:36
single month, we fight harder and harder
00:02:37
and harder and harder to bring you the
00:02:38
guests and conversations that you want
00:02:39
to hear. I've stayed true to that
00:02:41
promise since the very beginning of the
00:02:42
D of Sio, and I will not let you down.
00:02:45
Please help us. Really appreciate it.
00:02:47
Let's get on with the show.
00:02:56
Dr. Alex Tatum.
00:02:59
There's this word that has exploded in
00:03:01
society in recent times. In fact, when I
00:03:02
look at the data, people searching this
00:03:05
word has increased by 400%
00:03:08
just recently. And that word is
00:03:11
peptides.
00:03:12
I have no idea what peptides are. I'm
00:03:16
someone that wants to be healthy, that
00:03:18
wants to optimize my health, wants to
00:03:19
live long, doesn't doesn't love aging.
00:03:22
>> Yeah.
00:03:23
>> And I'm told that this word peptides is
00:03:25
somewhat linked to it. So, I've brought
00:03:27
you here because you're an expert on
00:03:28
this subject matter. I've watched your
00:03:29
videos on YouTube. To start at the very
00:03:31
beginning, Dr. Alex.
00:03:33
>> Sure. What the hell is a peptide?
00:03:35
Peptides are a structural class of
00:03:38
medications. The best way to think about
00:03:40
peptides is that just like we have small
00:03:42
molecules which are drugs that are very
00:03:45
small taken in a pill and have a wide
00:03:48
ranging effect throughout the body.
00:03:50
Peptides are derived from little pieces
00:03:53
of amino acids which think of them as
00:03:55
the Legos that make up the human body.
00:03:58
The Legos that make up proteins. These
00:04:00
are fragments of proteins that are
00:04:03
designed to specifically target certain
00:04:05
receptors and affect cells in a very
00:04:08
targeted fashion. Or a best way to think
00:04:10
about it is a very specific targeted key
00:04:13
to unlock a very specific lock. So
00:04:16
instead of a small molecule that may
00:04:18
have a wide ranging effect throughout
00:04:19
the body, peptides are much much more
00:04:21
focused.
00:04:23
>> So you've got different types of Lego
00:04:25
cubes here. Would they be different
00:04:27
types of peptides or are they different
00:04:29
types of amino acids that come together
00:04:31
to make a peptide?
00:04:32
>> The best way to think about it is my son
00:04:34
loves Legos, which is why I'm glad that
00:04:36
we have these here. But he can take the
00:04:38
same set of Legos and he can build a
00:04:41
rocket ship and then just a few minutes
00:04:43
later he can build a pirate ship and
00:04:46
then he builds a race car. And he's
00:04:48
using the same Legos, but he's creating
00:04:50
very, very different things that all do
00:04:52
very, very different things. And so
00:04:54
peptides have become incredibly popular
00:04:56
because yes, we have some really
00:04:58
fascinating peptides that can help with
00:05:00
anti-aging, with healing, and with
00:05:02
tissue repair. We're going to talk about
00:05:03
some of those hopefully, but they can do
00:05:06
so much more than that. The first
00:05:07
peptide that was actually isolated and
00:05:09
used in medicine, was insulin back in
00:05:10
1921.
00:05:12
And then all the way in 1985 in the
00:05:15
world of urology which is where I was
00:05:16
trained we had luplide which is a
00:05:19
different peptide that again also had
00:05:21
peptide like insulin but instead of
00:05:23
having wide-ranging metabolic effects it
00:05:25
had an endocrine effect. It was designed
00:05:26
to shut down the production of
00:05:28
testosterone for prostate cancer
00:05:30
patients that needed to have their
00:05:32
testosterone taken away.
00:05:34
>> Interesting. Okay. So insulin is a
00:05:35
peptide.
00:05:36
>> Insulin is a peptide
00:05:37
>> because it's a series of amino acids
00:05:39
>> amino acids that are put together.
00:05:41
>> Okay. So you said that the combination
00:05:43
of amino acids forms a key.
00:05:45
>> So what is the lock?
00:05:46
>> The lock could be a cellular receptor.
00:05:49
It could actually be regulating a
00:05:52
certain pathway within the cell.
00:05:53
>> Okay. So let me repeat this back to you
00:05:54
to make sure I understand it. So
00:05:56
peptides are like a key.
00:05:58
>> Yes.
00:05:59
>> Which you can make by configuring amino
00:06:01
acids in a certain way. And there's
00:06:03
different locks in our body that these
00:06:06
keys can go into. So if I take, you
00:06:08
know, we got some peptides on the table
00:06:10
in front of us here. So, a a good way to
00:06:13
think about it is this. If you've got a
00:06:16
hammer, right, which is what a lot of
00:06:18
small molecules are, like you can do a
00:06:20
lot with that, right? Like you could a
00:06:22
hammer in a nail, but if you try to use
00:06:24
that hammer when you're trying to put in
00:06:26
a screw or you're trying to put
00:06:27
together, you know, a table that you got
00:06:30
from IKEA, it may not always end the way
00:06:32
that you want to. And that's the problem
00:06:34
that we have with a lot of small
00:06:35
molecules. It's not that they don't do
00:06:37
what we want them to. They do a lot of
00:06:38
other things while they're at that job
00:06:40
that can have significant negative side
00:06:42
effects, which is why a lot of these
00:06:44
small molecules actually don't make it
00:06:46
all the way through the FDA approval
00:06:49
process because we find something, it
00:06:50
does what we want to do, but has
00:06:52
significant safety concerns down the
00:06:53
line. All right. Now, what we see with
00:06:56
peptides, for example, I've got in my
00:06:58
hand right now a little vial labeled,
00:07:00
you know, BPC57.
00:07:01
This is probably one of the most popular
00:07:03
peptides that we're talking about right
00:07:05
now because BPC-157 is a synthetic
00:07:08
version of a naturally found peptide in
00:07:11
the gut. But what this actually does is
00:07:15
it enhances blood vessel growth in areas
00:07:18
of injury. And it kind of makes sense
00:07:20
because if you think about it, our gut,
00:07:22
our stomach is really just this bag of
00:07:26
acid that sits inside of our abdomen.
00:07:28
And yet somehow you and I are here
00:07:30
talking to each other and our bodies
00:07:31
aren't eating themselves. Well, how does
00:07:32
that work? Well, it's because we've
00:07:34
developed a lot of really robust systems
00:07:36
to encourage healing of the gastric
00:07:38
lining. And so the idea is like, well,
00:07:40
if this is one of the compounds that can
00:07:42
help do that, it's been proven in
00:07:43
multiple animal models. For example,
00:07:45
they have completely transsected the
00:07:47
Achilles tendon in rats and then
00:07:49
>> transected
00:07:50
>> transected. So they've cut across the
00:07:52
Achilles tendon. So, not just a small
00:07:54
injury that you or I might experience in
00:07:55
the gym where we pull it or strain it,
00:07:57
but actually surgically cut the uh
00:08:00
Achilles tendon and then they administer
00:08:02
it to rats and they are healing
00:08:04
spontaneously with administration of
00:08:06
BPC7.
00:08:08
If you have an Achilles tendon injury
00:08:10
and you're a rat, BPC7 is one of the
00:08:12
best things that you can ever have. Now
00:08:14
that is not a onetoone translation to
00:08:16
what we might see in humans. But as we
00:08:18
talked about earlier with our point on
00:08:20
safety when they were studying BPC57
00:08:23
we try to look for something called the
00:08:25
LD1 or the LD50. How much can I give
00:08:28
this to someone until 50% of the
00:08:30
population that receives that dose
00:08:32
doesn't do well or dies. Okay, that's
00:08:34
called the LD50 dose. We have yet to
00:08:37
figure out what the LD1 dose is for
00:08:39
this, which is the amount that it would
00:08:41
take to hurt even 1% of the population
00:08:44
because it is so incredibly well
00:08:46
tolerated. So, just giving you an
00:08:48
example of this is a compound that can
00:08:51
have profound healing effects at least
00:08:53
in our animal models that we've seen so
00:08:55
far, but so far we haven't seen any
00:08:59
precipitous negative effects in human
00:09:01
patients when taking this. Okay. But we
00:09:04
need more data. I am mind blown and I'm
00:09:07
very very excited. We've got all of the
00:09:09
se several peptides here in front of us.
00:09:10
I want to go through all of that and
00:09:11
understand which ones do which things.
00:09:13
But there's a bigger question here which
00:09:15
is why now why have the subject of
00:09:19
peptides suddenly exploded into
00:09:21
society's consciousness? What's going
00:09:23
on? What's the big picture?
00:09:24
>> So this is really interesting. In 2013
00:09:28
there was actually a court case in the
00:09:29
United States. It was the it was called
00:09:32
Myriad Genetics case. This was the
00:09:34
company that actually patented the BRAA
00:09:36
1 and BA 2 genes. They discovered the
00:09:38
genes that cause breast cancer. All
00:09:39
right, this was mind-blowing. They
00:09:42
identified the specific genes that would
00:09:43
predispose patients to developing both
00:09:45
breast, ovarian, and since we've learned
00:09:47
also prostate cancer. It was a fantastic
00:09:49
discovery, but they patented it and they
00:09:51
said, "We now own this intellectual
00:09:53
property." And then everyone else said,
00:09:55
"No, no, no. That's that's the human
00:09:56
body. You can't patent that." And the
00:09:58
Supreme Court actually sided with that
00:10:00
argument saying that if something is
00:10:01
natural, it's found within us. Okay, I
00:10:04
can't patent you know your muscle cells,
00:10:06
right? Which is a wonderful thing. But
00:10:07
the unintention unintentional byproduct
00:10:10
of that is all of a sudden pharma had no
00:10:13
incentive whatsoever to pursue really
00:10:16
promising compounds that they could not
00:10:18
monetize. So that happens in 2013. At
00:10:22
the same time, I believe it was around
00:10:23
2012 2013, there was a terrible event
00:10:26
that happened in New England where there
00:10:28
was a compounding pharmacy that was not
00:10:30
doing the right thing and they ended up
00:10:32
having a bunch of contaminated specimens
00:10:35
that caused a fungal menitis. Bunch of
00:10:38
patients got really sick. It was a huge
00:10:40
scandal and all of a sudden the FDA
00:10:42
stepped in and said, "Hey, historically,
00:10:44
all right, states have been allowed to
00:10:47
regulate compoundingies themselves, but
00:10:48
we need some federal oversight here
00:10:50
because this is not acceptable."
00:10:52
Completely agree with that. And they
00:10:54
introduced a new set of regulations on
00:10:57
top of compoundingies, basically saying
00:10:59
what you can and cannot make. And what
00:11:02
they eventually said is, well, the only
00:11:03
you can only make three things. You can
00:11:06
make things that are in the USP uh
00:11:08
United States Pharmacopia, okay? Things
00:11:10
that have been, you know, well
00:11:12
described, already published, things
00:11:13
that are already in drugs that are
00:11:15
already on the market, or three, things
00:11:17
that are on a very specific list that
00:11:19
we're going to give you. Okay. And in
00:11:22
that list, they actually included a lot
00:11:25
of these very promising compounds that
00:11:27
were stuck in drug development, you
00:11:28
know, limbo.
00:11:29
>> And you say compoundingies, you said
00:11:32
that a few times. What is a compounding
00:11:33
pharmacy? Just just so I'm clear on the
00:11:35
definition.
00:11:35
>> Back in the 1800s or early 1900s, if you
00:11:38
ever needed a medication, you'd go see
00:11:40
the pharmacist who had a shop down the
00:11:41
road and he would actually make your
00:11:42
medication in front of you and he would
00:11:44
do that custom for every single patient
00:11:45
that came by. All right? And it was only
00:11:47
since the advent of modern factories
00:11:49
that we had the modern pharmaceutical
00:11:50
industry come about. But the truth is is
00:11:52
that again, you know, that's kind of
00:11:54
paint by numbers. You're creating this
00:11:55
one pill and you know, it always seemed
00:11:58
kind of crazy that the adult dose is one
00:12:00
standardized dose for all adults. Like
00:12:03
if you look at what your body
00:12:04
composition is some of my patients, why
00:12:06
is the dose your blood pressure medicine
00:12:08
the exact same? Like that doesn't seem
00:12:09
to be quite right. But it is what it is.
00:12:11
So when patients fall outside of that
00:12:13
and they need custom medication, we
00:12:15
still have those people who make custom
00:12:18
formulations of medications, but instead
00:12:20
of it being just your local pharmacist
00:12:21
who's using a mortar and pestle and you
00:12:23
know is creating something in his back
00:12:24
office, these are now large
00:12:26
sophisticated industrial operations that
00:12:28
can make custom formulations for
00:12:29
patients. I think I think the important
00:12:31
context for people that don't understand
00:12:33
how drug development occurs is that to
00:12:36
get chemicals like the ones we have in
00:12:37
front of us on the table through FDA
00:12:40
approval, you've got to spend millions
00:12:41
and millions and millions of dollars,
00:12:43
>> tens if not hundreds of millions of
00:12:44
dollars.
00:12:44
>> Sometimes hundreds of millions of
00:12:45
dollars.
00:12:45
>> Yeah. An incredible amount of money. And
00:12:47
>> and if you know you can't protect it
00:12:49
once you spend $100 million, you have no
00:12:51
incentive to just do charity work.
00:12:52
>> Absolutely not. Okay. Because you have
00:12:55
shareholders and you have to make
00:12:56
payroll. And so because drug development
00:12:59
is so expensive, there is no incentive
00:13:02
for commercial pharmaceutical companies
00:13:04
to pursue the development of these
00:13:05
compounds. And then on the other side of
00:13:08
that, well, we have compoundingies that,
00:13:10
you know, for them it makes sense. What
00:13:12
if we could just make these compounds
00:13:13
and then sell them directly to patients?
00:13:15
We make a small margin. We sell it. This
00:13:16
makes sense for us. Well, they could do
00:13:18
that starting in about 2014 whenever
00:13:20
that legislation finished. All right.
00:13:22
>> What did it do? Essentially what it did
00:13:24
is it gave a it gave a assignment to
00:13:28
each one of these compounds. It was
00:13:30
either going to be category one which is
00:13:32
you uh can compound this. This is on our
00:13:34
specific list of approved compoundable
00:13:36
drug ingredients. Number two was hey we
00:13:39
see some negative safety signals here.
00:13:41
You cannot make this. Okay. Something
00:13:42
goes on category 2. It's forbidden. And
00:13:44
then we have category three which is we
00:13:46
just need more information. And all of
00:13:48
these original compounds, these peptides
00:13:50
that we're so interested in now were
00:13:51
originally on that first list, category
00:13:54
one. All right? And so they were able to
00:13:56
be compounded. We could prescribe them
00:13:58
patients. I prescribed them to patients.
00:14:00
All right? From 2014 onward. But then in
00:14:04
2023, the FDA at that time switched all
00:14:07
of those peptides, 19 of them that were
00:14:10
popular to category 2. And then they
00:14:12
were banned. Overnight, we got
00:14:14
notifications in our email inboxes from
00:14:15
our compounding pharmacy partners
00:14:17
saying, "Hey, we can't make this
00:14:18
anymore. We're sorry."
00:14:19
>> So, I've got two questions there. Yes.
00:14:21
>> Um, the first is when you were
00:14:23
prescribing these pepsides to your
00:14:25
patient,
00:14:26
>> yes.
00:14:27
>> Were you seeing incredible results?
00:14:29
>> Very much so. Very much. Again, you have
00:14:32
to use the right key for the right lock.
00:14:34
Okay. But I think a really good example.
00:14:38
All right. So, there is a compound that
00:14:41
is not technically a peptide. It is a
00:14:43
small molecule but it was lumped in with
00:14:44
all of these and was the victim to the
00:14:46
same process. Uh something called MK677
00:14:50
also known as ibutamorin. So this is a
00:14:52
small molecule but when a patient takes
00:14:54
it it's orally available it binds to
00:14:56
this receptor called ghrein and it
00:14:58
actually stimulates the release of
00:14:59
significant growth hormone. But what was
00:15:01
really interesting is that it would
00:15:03
actually stimulate hunger a profound
00:15:05
amount. And all of a sudden patients
00:15:07
that were struggling with cexia, okay,
00:15:09
so being very very thin, very
00:15:11
malnourished, maybe they're going
00:15:12
through cancer treatment.
00:15:13
>> Grein's the thing that makes us feel
00:15:14
hungry.
00:15:15
>> Absolutely. Yeah. Yeah. So they were
00:15:17
able to stimulate the hunger response
00:15:19
and patients were actually able to eat
00:15:21
more to meet caloric goals. And so this
00:15:24
was a medication that was fantastically
00:15:26
effective at that. Again, it had gone
00:15:28
through some clinical trials, but was
00:15:30
never taken all the way to commercial.
00:15:33
And so it was never going to be
00:15:34
available from CVS or Walgreens, but you
00:15:37
could get it from a compounding
00:15:38
pharmacy. And so that was one that made
00:15:40
a big difference for us. We also had
00:15:42
other peptides. So, uh, GHRP2 and GHRP6
00:15:45
were some of the ones we were using at
00:15:47
that time. Uh, those are growth hormone
00:15:49
releasing peptides that stimulate the
00:15:52
release of your body's natural growth
00:15:53
hormone, which can help with tissue
00:15:55
repair, can also help with fat loss, and
00:15:57
with building muscle. We also had
00:15:59
BPC-157
00:16:01
and we had uh derivatives like thymus
00:16:03
and beta 4. These are also compounds
00:16:06
that can help stimulate angioenesis, so
00:16:08
making new blood vessels. All right? And
00:16:10
tissue repair. So if we have a patient
00:16:12
that's injured themselves, maybe we
00:16:13
could help them get back at life faster.
00:16:16
These were all things that were used
00:16:17
very commonplace for many years. And
00:16:19
truthfully, they weren't super popular
00:16:21
at the time. We were just using them.
00:16:23
And then they were banned overnight.
00:16:25
>> And they were working.
00:16:26
>> And they were working. And they were
00:16:27
working. We were not seeing adverse
00:16:28
events, which is the most important
00:16:30
thing.
00:16:31
>> What's an adverse event?
00:16:32
>> An adverse event is a patient has a
00:16:34
terrible side effect. They call you,
00:16:36
they have an allergic reaction to
00:16:37
something, they call, they've got
00:16:38
shortness of breath, and it's a direct
00:16:40
result of the medication that you gave
00:16:41
them. It was working. It was working and
00:16:43
by all accounts seemed to be incredibly
00:16:45
safe.
00:16:45
>> And then they banned it.
00:16:46
>> And then they banned it.
00:16:47
>> Why?
00:16:48
>> That's a great question. So officially
00:16:51
what happened is there was a meeting
00:16:53
where they brought together the experts
00:16:55
at the time and they said there is
00:16:56
insufficient data for us to say that
00:16:58
these are safe because again they had
00:16:59
not gone through the full FDA approval
00:17:01
process and so as a result of lacking
00:17:04
that data we're going to say that
00:17:06
they're too dangerous. Now there wasn't
00:17:07
any evidence of any of that in the
00:17:09
population. These were widely used at
00:17:10
the time. potentially we had commercial
00:17:14
pharmaceutical companies saying well hey
00:17:16
this is people spending money on a
00:17:18
compound on something that isn't coming
00:17:20
to us. So hey like we love medicine but
00:17:24
maybe only when it's our medicine.
00:17:26
>> And so there's concern that that was at
00:17:28
play as well. And so there's not a great
00:17:30
paper trail and there's not a great
00:17:31
explanation why. And that's something
00:17:32
that's been iterated by our current
00:17:34
administration from RFK himself. You
00:17:37
know, he himself has characterized that
00:17:38
move done in 2023 as being illegal.
00:17:41
>> With everything you know about the
00:17:42
medical industry, do you think it is
00:17:44
plausible that big farmer
00:17:47
>> 110%.
00:17:48
>> Didn't want
00:17:49
>> 110%.
00:17:51
>> These in the hands of regular people
00:17:52
because they can't patent this and it's
00:17:55
powerful.
00:17:55
>> So ultimately the way to think about it
00:17:58
is this. Um,
00:18:02
pharma may not have a compound that
00:18:04
directly competes for BPC57.
00:18:07
>> BPC-157.
00:18:08
>> So, this is the medication or the
00:18:10
peptide that can aid with healing after
00:18:13
an injury. Okay? So, it's not
00:18:15
necessarily there's direct competition,
00:18:17
but at the end of the day, your average
00:18:19
patient going throughout their daily
00:18:22
life only has so much money that they
00:18:23
can spend on medicine. and $10, $15,
00:18:28
however much money that goes to this
00:18:30
doesn't go to a prescription drug from a
00:18:32
commercial pharmaceutical company. And
00:18:34
so there is real concern that
00:18:35
potentially that was at play during that
00:18:37
decision. And
00:18:38
>> you said 110%.
00:18:39
>> Yeah. I Well, you know, it's interesting
00:18:41
because, you know, I try to walk a very
00:18:44
fine line between what I can prove uh
00:18:46
versus what I suspect after being in
00:18:49
this space for a long time. And you know
00:18:52
ultimately you know I don't think it's
00:18:54
accurate to characterize pharmaceutical
00:18:57
companies or really any other entity as
00:18:59
being you know evil or or bad. The truth
00:19:03
is maybe a little bit more ominous. The
00:19:04
truth is is that they are these large
00:19:07
machines that are designed to prioritize
00:19:09
profit over everything.
00:19:10
>> Yeah.
00:19:11
>> And that's everything.
00:19:12
>> I think this is one of the really
00:19:13
interesting observations I've had the
00:19:15
higher I've gone in my career is that
00:19:17
often times you we heard about the
00:19:18
Illuminati. Like when I was growing up,
00:19:19
I was like, "Oh, there's this
00:19:20
Illuminati."
00:19:21
>> And you think of it as these like shadow
00:19:23
hooded people that get together and
00:19:24
decide evil things. But the further I've
00:19:26
gone in business, the more I've realized
00:19:27
that the Illuminati or these evil forces
00:19:29
are actually just machines that were
00:19:31
designed to optimize for profit.
00:19:32
>> Correct. Correct.
00:19:33
>> So like corporations are the Illuminati.
00:19:36
>> Yeah. And so I don't actually think that
00:19:37
there's necessarily, you know, a a group
00:19:40
of maniacal individuals, you know, the
00:19:42
Legion of Doom, you know, plotting to
00:19:44
like take away your health. But at the
00:19:46
same time, I think that there are these
00:19:48
large organizations that really couldn't
00:19:49
care less about your health. You know,
00:19:51
they are prioritizing what's important
00:19:52
for them. And regular people just get
00:19:55
caught up in the mix. And what's
00:19:56
challenging is that as a physician, you
00:19:58
know, I took a hypocratic oath. You
00:20:00
know, I care about my patients. And so
00:20:02
those are the people that are in front
00:20:03
of me every single day that are seeking
00:20:05
to improve their lives to recover from
00:20:07
injury. I have, you know, fertility
00:20:08
patients that are just dying to start
00:20:10
their family. And I have patients that
00:20:12
are suffering from hormonal imbalances
00:20:14
that haven't felt right in years. I I
00:20:16
treat erectile dysfunction in men that
00:20:17
have been struggling for years after
00:20:19
prostate cancer treatment. I mean, these
00:20:20
are people that are broken and hurting.
00:20:22
You want to be able to help them. And
00:20:24
so, I feel that is a very strong
00:20:26
personal calling that I have to be that
00:20:28
advocate for that patient both in the
00:20:30
room whenever I'm treating them and
00:20:31
taking care of them, but also when I'm
00:20:33
talking to others and I'm, you know,
00:20:35
speaking out about these issues. like I
00:20:37
want access to these medications because
00:20:38
I care about the patients who benefit
00:20:40
from them.
00:20:42
>> So they banned these peptides that we
00:20:44
have here,
00:20:45
>> correct?
00:20:45
>> And we're sat here 2 years after the
00:20:46
ban, I believe, roughly 2 years after
00:20:48
that ban.
00:20:48
>> Yeah.
00:20:49
>> And suddenly everybody's talking about
00:20:50
peptides again.
00:20:51
>> Yes.
00:20:52
>> Why? What's going on?
00:20:53
>> So I think what we're seeing is the
00:20:56
forbidden fruit effect because this was
00:20:58
banned and all of a sudden, oh well,
00:20:59
why'd they ban it? Well, they wouldn't
00:21:00
have banned it if it weren't working,
00:21:01
right? And we're also seeing the effect
00:21:04
of Tik Tok and short form content being
00:21:06
spread very rapidly, very virally. And
00:21:08
that's been going on for two years now,
00:21:10
combined with new uh emphasis from
00:21:13
administration leadership and HHS and
00:21:15
RFK.
00:21:16
>> What is the most incredible
00:21:19
impact that you've seen peptides create
00:21:21
in a patient?
00:21:22
>> Oh my gosh, I have the best story for
00:21:24
you. So, one of the most frustrating uh
00:21:27
things about my practice is treating
00:21:30
infertility in young men that have
00:21:32
significant metabolic dysfunction. These
00:21:35
are young men that have a low sperm
00:21:37
count, right? So, they can't get
00:21:39
pregnant because they just don't have
00:21:40
the numbers to make it happen. And
00:21:42
you're looking at them and they're
00:21:43
morbidly obese, okay? They have high
00:21:45
insulin resistance. All right? And their
00:21:48
endocrine system has been damaged by
00:21:49
that obesity. So they don't have have
00:21:51
low testosterone levels and their brain
00:21:53
is not making enough of the signals to
00:21:55
stimulate their testicles. Now we have
00:21:57
medications that we can use to help
00:22:00
stimulate that to make more of that
00:22:01
signal stimulate the testicles, right?
00:22:03
But really what is eating at them, what
00:22:06
is causing this is not that chemical
00:22:08
imbalance. That's the the symptom.
00:22:09
That's not the the problem. Okay? And
00:22:11
treating symptoms doesn't really get you
00:22:13
very far. And so I would have patients
00:22:14
that I would take care of and we would
00:22:16
never see a significant improvement in
00:22:17
their numbers because losing weight is
00:22:19
really really hard. you know, regardless
00:22:20
of all of the education and resources I
00:22:22
try to give them. But now we have
00:22:24
peptides in the form of GLP-1 drugs like
00:22:28
simaglutide and tzepatide. And I just
00:22:30
saw a patient le last week who increased
00:22:33
his sperm count 10 times over and is now
00:22:36
in a normal range because he's lost 100
00:22:39
pounds due to using tzepatide,
00:22:42
exercising, and improving his diet. And
00:22:44
he has totally changed his life.
00:22:46
>> And that started with a peptide.
00:22:47
>> It started with a peptide. So I we've
00:22:49
got lots of peptides on the table in
00:22:50
front of you. We will go to into them
00:22:52
individually, but just can you give me a
00:22:54
a highle view of the types of areas in
00:22:57
our health and life that these peptides
00:22:59
can help with? So we've talked there
00:23:00
about infertility,
00:23:01
>> correct?
00:23:02
>> As a downstream consequence of the like
00:23:03
weight loss and fixing metabolic health,
00:23:06
what what other parts of the body do
00:23:08
peptides touch?
00:23:09
>> The best way to think about it is like
00:23:10
this. So peptides are almost like an app
00:23:14
on your phone. So imagine before we had
00:23:17
apps. Like I I'm old enough to remember
00:23:19
trying to log on and do my banking
00:23:20
online before we had apps. And gosh, it
00:23:22
was so painful, right? Like there were
00:23:24
ways to accomplish things, but they were
00:23:25
very inconvenient and in a roundabout
00:23:27
way. And now all of a sudden, we have
00:23:28
these apps on our phone that can do just
00:23:30
about anything except fold your laundry,
00:23:32
right? You know, there's some limits to
00:23:33
it, but I mean really the sky's the
00:23:35
limit from an electronic standpoint. And
00:23:37
really, that's what peptides are. So the
00:23:39
thing is is that we have peptides that
00:23:42
can help you lose weight, like the GLP-1
00:23:44
drugs. We have peptides that can improve
00:23:47
skin quality like uh GHKCU.
00:23:50
We have peptides that can help heal your
00:23:52
gut like BPC 157 particularly effective
00:23:55
in ulcerative colitis which is something
00:23:57
that's being investigated with the FDA's
00:23:59
planned upcoming meeting on it. We also
00:24:01
have peptides that can help with sleep
00:24:04
and with uh recovering the gland in your
00:24:06
brain that's responsible for melatonin
00:24:07
and regulating your sleep wake cycles.
00:24:10
So the question isn't you know what can
00:24:12
peptides do? kind of well what can't
00:24:14
they do and if they can't do that yet
00:24:16
can we develop a peptide that can
00:24:17
accomplish that task and the answer is
00:24:20
probably and simultaneously while there
00:24:22
may be resistance from pharmaceutical
00:24:24
industry in these peptides the ones that
00:24:26
we're most interested right now they
00:24:28
have signed multi-billion dollar deals
00:24:30
with other pharmaceutical companies that
00:24:33
are involved in peptide uh development
00:24:35
aided by AI to try and fasttrack their
00:24:38
own peptide uh products
00:24:40
>> interesting
00:24:40
>> and so we are going to see exponentially
00:24:43
more of these products come down the
00:24:44
pipeline from pharmaceutical companies
00:24:46
in the form of commercial products.
00:24:48
>> And it's worth saying that there was
00:24:49
some significant news today.
00:24:51
>> Correct.
00:24:51
>> What happened today, but also what's
00:24:53
going on. And just for anyone that
00:24:54
doesn't know, it's April the 15th.
00:24:56
>> Yes. So today uh we got a press release
00:25:00
from the FDA saying that in July they
00:25:03
are going to consider seven peptides for
00:25:06
removing from category 2 back to
00:25:09
category 1,
00:25:09
>> legalizing them.
00:25:10
>> Legalizing them. Okay. And uh some of
00:25:14
the heavy hitters from that list include
00:25:17
BPC uh 157,
00:25:19
>> which is the one we talked about to do
00:25:20
with like repair and injury.
00:25:22
>> Absolutely. Okay. And then we have uh
00:25:24
the brother to that, which is TV500.
00:25:27
This vial over here, this improves blood
00:25:30
flow to an injured area. You could think
00:25:31
of this as sending the soldiers as
00:25:34
sending the cells that are required for
00:25:36
rebuilding that tissue matrix that was
00:25:38
damaged by a tear or a cut. All right.
00:25:41
On top of that, uh we're also getting
00:25:43
something called uh KPV. May not have it
00:25:45
here, but that is another uh peptide
00:25:48
that has been linked to angioenesis and
00:25:51
tissue repair. We're also getting MOT C
00:25:54
and you know, some patients will call it
00:25:55
exercise in a vial. It improves your V2
00:25:58
max and your exercise tolerance. And by
00:26:00
up uh regulating the energy pathway,
00:26:03
basically making more ATP, the energy
00:26:04
that we all use to move, it makes more
00:26:06
of that available. All right, we're also
00:26:09
going to get DIP, epylon, and CAX, which
00:26:12
are all peptides that affect cognitive
00:26:15
function. So, improving thinking like uh
00:26:17
CAX is a great option for that. And then
00:26:20
DIP and epylon both have roles in
00:26:22
regulating uh sleep and recovery.
00:26:25
>> Wow.
00:26:26
>> Yeah. Pretty wild.
00:26:28
And I've got to say, how does So, some
00:26:30
of them are becoming legalized, but even
00:26:32
the ones that aren't legal right now, a
00:26:33
lot of people are taking them anyway.
00:26:35
>> Correct. So my my question is how are
00:26:37
people getting them? Listen, I don't
00:26:38
want to promote illegal drugs here. This
00:26:40
is not that kind of [ __ ] but I just
00:26:42
want to know what's going on.
00:26:43
>> No, this is well this is important to
00:26:44
talk about, right? We have to understand
00:26:46
like what's going on in the marketplace.
00:26:47
The moment that these drugs were banned
00:26:50
or these medications were banned in
00:26:51
2023, it was kind of like the United
00:26:53
States experiment at banning alcohol, it
00:26:55
didn't go very well, right? All of a
00:26:57
sudden, you know, they we, you know, the
00:26:59
mob came around and we started, you
00:27:01
know, seeing unregulated uh uh saloons
00:27:04
and unregulated alcohol production and
00:27:06
it was contaminated with all the stuff
00:27:07
that you didn't want. And so we're like,
00:27:08
>> people are traveling.
00:27:09
>> Yeah. Exactly. It's just it's not a good
00:27:11
idea, right? And so what happened is we
00:27:13
banned these and the gray market stepped
00:27:15
in. And so these are companies that will
00:27:18
sell peptides that have on the label for
00:27:21
research use only. All right? And the
00:27:23
idea is that that takes them out of the
00:27:25
FDA's jurisdiction because they're not
00:27:26
selling it for people to inject into
00:27:27
themselves, out of the FDA's hands. I'm
00:27:30
just creating a vial of this magical
00:27:32
juice that you can use for your rat.
00:27:34
Okay, that's the idea. We all know
00:27:36
that's not what's really happening. But
00:27:38
because there isn't any quality control,
00:27:41
it's kind of like getting gas station
00:27:42
sushi. Like, yeah, you can do it, but
00:27:44
you don't really know if it's sushi, and
00:27:46
it may not end very well for you. And so
00:27:48
again, not saying that there aren't some
00:27:50
people who have gotten good results with
00:27:52
research use only peptides, but again,
00:27:55
it's not standardized, which is why I
00:27:57
think moving this back into the 503A
00:27:59
compounding world is the best thing for
00:28:01
everyone,
00:28:01
>> which is the legal framework. Okay, so
00:28:04
how does one take a peptide?
00:28:05
>> That's a great question. So what's
00:28:07
interesting is that, as we mentioned,
00:28:09
you know, peptides are just made up of
00:28:10
building blocks of amino acids. And you
00:28:12
know, if you were to go make yourself a
00:28:14
uh protein shake, you know what is that
00:28:16
gonna look like from a Lego standpoint?
00:28:17
It just looks like this. A handful of
00:28:19
Legos in your hand, right?
00:28:20
>> All sort of ground up.
00:28:21
>> All ground up in individual pieces,
00:28:23
right? And the thing is is that your gut
00:28:25
is designed to break up any sort of
00:28:28
protein that you ingest orally into
00:28:30
these little pieces. And so if you were
00:28:33
to say, I don't know, drink some of, you
00:28:35
know, this TB500, your body wouldn't be
00:28:38
able to tell the difference between that
00:28:39
and a piece of chicken
00:28:39
>> cuz it would it would break it all
00:28:41
apart. break it all apart. Now, there
00:28:42
are some very uh unique exceptions to
00:28:44
that. There's a form of BPC157 that
00:28:46
actually is tolerated in the gut, but by
00:28:49
and large, the overwhelming majority of
00:28:50
these have to be injected either
00:28:52
subcutaneously or into the muscle. And
00:28:54
that's usually a preference.
00:28:56
>> Subcutaneous being my belly
00:28:57
>> under just underneath the skin. You
00:28:58
know, as I tell patients, just pinch an
00:29:00
inch, inject under the skin. We do that
00:29:01
for a lot of other medications as well.
00:29:03
>> Is that what this is?
00:29:04
>> Yeah. So, this is a prescription MARO
00:29:07
pen. So, Mangjaro is the brand name for
00:29:10
Tzepide. All right, trespatide being the
00:29:13
leading GLP-1 product right now from
00:29:15
Lily. So, this produces more weight loss
00:29:18
per milligram than any other product
00:29:20
that we've got out right now.
00:29:21
>> Is this the mechanism in which people
00:29:23
inject peptides?
00:29:25
>> No, a little bit different. So, this is
00:29:27
an auto injector pen. And so, what you
00:29:29
do is you're able to actually ratchet
00:29:30
the dose there on the right side and
00:29:32
then you pinch an inch in your skin and
00:29:34
then push it up against and it'll
00:29:35
autodeploy. And so, there's nothing that
00:29:36
you need to do. You don't have to learn
00:29:38
how to drop medication and inject.
00:29:40
Whenever you're administering peptides
00:29:42
at home, especially for patients that
00:29:44
have obtained them from research use
00:29:45
only markets, they usually come in just
00:29:47
little vials that need to be drawn up
00:29:49
with a needle. Okay? Now, the benefit of
00:29:52
that is that you can do custom dosing.
00:29:54
All right. But the drawback is is that
00:29:56
well, you have to know how to calculate
00:29:57
that and put it together. This may be
00:30:00
the most controversial thing we have on
00:30:02
this table. And by farmer's estimate, it
00:30:06
might be the most dangerous thing to
00:30:07
their entire business model because this
00:30:10
is trozepatide, the exact same thing
00:30:12
that you had in that pen. But this is
00:30:14
made by a highquality 503A compounding
00:30:17
pharmacy. And the reason why this is uh
00:30:21
so controversial right now is because it
00:30:23
offers an incredible amount of
00:30:25
flexibility because what you have in
00:30:26
your hand there is very standardized and
00:30:28
you administer it once a week because
00:30:30
that's what's approved by interest.
00:30:31
>> This is like the thing everyone's been
00:30:32
talking about.
00:30:33
>> Exactly. Yeah, but think of that as
00:30:35
paint by numbers. Okay, you are this
00:30:39
section is this color. This section is
00:30:40
that color. All right. Think of this as
00:30:43
>> the thing you've got in your hand
00:30:44
>> right now. Yeah, exactly. Just a vial of
00:30:46
trapide as being a having infinite
00:30:49
permutations and dosing ability because
00:30:51
you can draw this up with a small
00:30:53
syringe and do micro dosing. So instead
00:30:55
of one large dose once a week because
00:30:57
what many patients will experience is
00:30:58
they'll have a return of their hunger by
00:31:00
the end of the week and they end up
00:31:02
losing ground. You can actually instead
00:31:04
of doing a full dose once a week, you
00:31:06
could do multiple mini doses throughout
00:31:08
the week with this formulation and with
00:31:10
this presentation of the medication. All
00:31:12
right, but the challenge is is that that
00:31:14
is the benefit that allows this to be
00:31:16
compounded by compoundingies because
00:31:18
they are able to provide something that
00:31:21
is similar to what's in your hand. All
00:31:22
right. But it offers more flexibility
00:31:25
that may be the right choice for some
00:31:27
patients. So personaliz personalization
00:31:28
of medicine. Okay. But the challenge is
00:31:31
is that if you spend however much money
00:31:33
on this, you're not giving it to Lily.
00:31:36
And so as a result, we have seen an
00:31:38
unprecedented crackdown in the United
00:31:40
States from the FDA and trying to shut
00:31:43
down compoundingies and prevent them
00:31:45
from making these medications. Even
00:31:48
though that ability to customize the
00:31:50
fact that this is not an exact copy of
00:31:52
what's in your hand right now should
00:31:54
protect it under current legislation,
00:31:57
but there is now enough pressure from
00:31:59
the powers that be and from lobbyists
00:32:02
from both Lily and Nova Nordisk that
00:32:04
which are the two companies that make
00:32:06
the GLP-1 medications that we're seeing
00:32:09
Marty Macher the FDA commissioner has
00:32:12
now tweeted more about cracking down on
00:32:14
compounded GLP-1 medications than he's
00:32:16
tweeted about diabetes. disease or heart
00:32:17
disease in his entire time in office.
00:32:20
>> And just so I understand, I want to play
00:32:21
this back to you to make sure I
00:32:22
understand.
00:32:23
>> Sure.
00:32:24
>> In my hand here, I have
00:32:27
Tepatitide on my left.
00:32:29
>> And this is made by Lily, which is a
00:32:30
corporate company who've patented it, so
00:32:33
they can make lots of money from it.
00:32:34
>> Correct.
00:32:34
>> In my right hand, I have tepide
00:32:38
with nycinomide
00:32:40
>> with nyinomide. Y
00:32:41
>> and this is not patentable. So Lily has
00:32:45
a patent on the trazepatide molecule in
00:32:48
that formulation in your hand. Okay.
00:32:50
>> And if anyone violates a patent that can
00:32:54
be pursued in US court. Yeah. Patent
00:32:57
law. Right. But what's interesting is
00:33:00
that Lily and Novo Nordisk know that
00:33:03
that's different in your right hand. It
00:33:04
doesn't look the same. You can dose it
00:33:06
differently. And they know that if they
00:33:08
were going to fight that in court, it
00:33:10
would cost a lot of money and take a lot
00:33:12
of time. So, you know what's a lot
00:33:13
easier? Calling your friend at the FDA
00:33:15
and getting him to step on the
00:33:17
competition so you don't have to. And
00:33:18
then who's paying for that enforcement?
00:33:21
It's not the lawyers that the pharma
00:33:24
company is paying for. Uh it's the
00:33:26
taxpayer paying for the FDA through
00:33:28
taxes.
00:33:28
>> And you seem to imply that this was
00:33:30
actually better because you could take
00:33:31
it in a more flexible dose. You could
00:33:33
take a little bit, a lot, you can take
00:33:34
it when you want. Whereas this is kind
00:33:36
of once a once a week.
00:33:37
>> Well, I mean, you know what is better,
00:33:39
right? So I like this option for many of
00:33:41
my patients because it's flexible. All
00:33:43
right, so that is something that works
00:33:45
for most patients. All right, but then
00:33:46
then again, this works great for
00:33:48
patients too. Okay, but what you want is
00:33:50
you want an ecosystem where you have
00:33:52
choice so you can make the right choice
00:33:53
for the right patient. For a lot of
00:33:55
patients, they're going to do
00:33:56
exceedingly well on this. And there's so
00:33:58
much data to support that. But I also
00:34:01
have a lot of patients who get really
00:34:03
ill after they do a large dose of
00:34:05
Mangaro or of GLP-1 med. And if we take
00:34:08
that same dose and we just cut it into
00:34:10
multiple doses within a week, we can
00:34:11
avoid those side effects.
00:34:13
>> So you've told me that these peptides we
00:34:15
have on the table in front of us can
00:34:16
improve your skin, weight loss, muscle,
00:34:19
energy, chronic illnesses. You talked
00:34:21
about the cognitive upsides and you talk
00:34:24
about it very passionately.
00:34:25
>> Yeah.
00:34:26
>> So one should ask you presumably you're
00:34:28
taking some peptides.
00:34:29
>> I am. Yeah. So
00:34:30
>> which ones do you take? So I will tell
00:34:32
you that as of right now the only
00:34:34
peptide I'm taking is a small dose of
00:34:37
tzapatide. All right.
00:34:38
>> Which is the one we were just talking
00:34:39
about.
00:34:39
>> Yeah. Okay.
00:34:40
>> Because back uh couple of couple of
00:34:42
months ago I was probably close to about
00:34:46
240 or so and I was into powerlifting.
00:34:48
You know I still am. But you know it's
00:34:50
really great to be able to deadlift 500
00:34:52
lb. But then stairs become really hard
00:34:54
when you're trying to walk up and you're
00:34:56
like I don't know. I kind of like uh
00:34:58
being able to not take a break after two
00:34:59
or three flights of stairs. And so I was
00:35:01
like, "Okay, all right. Longevity is a
00:35:03
priority of mine. I'm going to slim down
00:35:04
a little bit." I like, "Let me just try
00:35:06
this for a little bit." And what I found
00:35:07
is that it is incredibly potent and at a
00:35:09
very low dose, very, very tolerable.
00:35:12
>> Why didn't you take some of the others?
00:35:13
>> Honestly, because right now there is not
00:35:16
a legal framework for me to obtain them.
00:35:18
And the truth is is that I want to be an
00:35:20
example for my patients. And that's why
00:35:22
I'm out here advocating that we get
00:35:25
access to these peptides in a legal,
00:35:26
safe way again. All right? And because
00:35:29
it's it's the best thing for everyone.
00:35:30
>> If they were legal, which ones might you
00:35:33
consider?
00:35:34
>> Oh, man. I will tell you this as some
00:35:36
like I I don't know how old you are,
00:35:38
Stephen, but I'm 33. God bless you. I
00:35:40
will tell you once you get over 35, man,
00:35:42
that is brutal. All right. I sleep on my
00:35:44
neck in a wrong way and I need like a
00:35:46
freaking brace for like two weeks. And
00:35:48
so, as someone who spends a lot of time
00:35:50
in the gym, you know, working out, like
00:35:51
you start to accumulate all these little
00:35:53
aches and pains. And so the idea of, for
00:35:55
example, I have a a very finicky right
00:35:57
shoulder. If I try to do a really heavy
00:36:00
bench and I haven't warmed up, I can
00:36:02
tweak this and it takes me out of the
00:36:03
fight for at least a month, okay? And I
00:36:05
have to do other things. You know, I
00:36:07
would have killed at various points in
00:36:08
time over the past two years to have had
00:36:11
BPC and TB500 to hopefully speed that
00:36:14
sort of healing. All right. Um, also,
00:36:16
for example, I suffer from really bad
00:36:19
rosacea. It flares constantly.
00:36:21
>> What's that? So, just a redness of the
00:36:23
face, okay, that you know, it makes me
00:36:25
look like I'm sunburned. And then I come
00:36:26
in on the office on like a Tuesday and
00:36:28
then my staff's like, "Oh my gosh, you
00:36:29
go out in the yard and do some work this
00:36:30
week." I'm like, "It's just my face."
00:36:32
Um, you know, for example, that's
00:36:34
something that a lot of people have
00:36:35
reported benefits from GH KCU from. So,
00:36:38
again, another compound, another peptide
00:36:41
that could be beneficial for a patient
00:36:42
like myself.
00:36:43
>> What about muscle mass and gaining
00:36:45
muscle? Yeah. So, that is an interesting
00:36:48
misnomer because that has been a common
00:36:51
selling point you'll see on social
00:36:52
media. But as of right now, the only
00:36:56
peptide that you might construe that way
00:36:59
would be this guy right here in my hand,
00:37:02
IGF-1 LR3. Okay. Now, IGF-1 LR3 is
00:37:06
basically the longerlasting version of
00:37:08
IGF-1, which is the downstream effect of
00:37:11
growth hormone. I'm sure you've heard of
00:37:13
bodybuilders taking growth hormone to
00:37:14
increase size and, you know, lose fat.
00:37:16
In higher doses, it can help contribute
00:37:18
to muscle uh mass. All right? But
00:37:21
truthfully, if you're trying to gain
00:37:23
significant muscle mass, this is this is
00:37:25
not the way to do it. And so, the right
00:37:28
now, one of the things that peptides
00:37:30
can't do for you is independently put on
00:37:33
significant amounts of lean mass.
00:37:34
>> You still have to go to the gym.
00:37:35
>> You still have to go to the gym, believe
00:37:36
it or not. And guess what?
00:37:38
>> Well, that's the end of the podcast.
00:37:39
>> Yeah. I I'll tell you. And but something
00:37:41
that blows my mind is that I have so
00:37:42
many patients that think that they can
00:37:44
just take testosterone and just put on
00:37:46
muscle naturally. And it doesn't work
00:37:47
that way. You might get a tiny little
00:37:48
bit, but you still have to have
00:37:50
stimulus. You still have to get in the
00:37:51
gym. You still have to put the work in.
00:37:53
And so I tell patients that I am not a
00:37:54
replacement for a personal trainer. I'm
00:37:56
your doctor. You also need your personal
00:37:58
trainer. And most of you need a
00:37:59
nutritionist, man. And so I'm lucky to
00:38:02
work with some great people in the
00:38:03
community who partner with me on that.
00:38:04
But you know it's a it's a fullcourt
00:38:06
press when you're trying to get people
00:38:07
to you know live the highest quality of
00:38:09
life.
00:38:09
>> What about some of these metabolic
00:38:11
disorders and diseases in terms of like
00:38:12
insulin yeah resistance? People on the
00:38:15
di the audience are very interested to
00:38:17
learn about insulin. I see that a lot in
00:38:19
the comments section and a lot of the
00:38:20
data. Yeah.
00:38:21
>> So how can if someone's struggling with
00:38:23
their insulin levels or their you know
00:38:24
their glucose response how does these
00:38:26
peptides help?
00:38:26
>> Honestly the best peptides for that
00:38:28
right now are the GLP1 drugs. Okay.
00:38:30
Hands down. because what you're doing is
00:38:32
you are slowing gastric emptying and so
00:38:34
you have a slower absorption of that
00:38:38
bolus of food that you've eaten so your
00:38:39
glucose doesn't spike and so as a result
00:38:42
that increases insulin sensitivity
00:38:44
significantly. Now again you have to be
00:38:46
careful about what peptide you're using
00:38:48
for what. A lot of these peptides that
00:38:50
boost growth hormone and boost let's say
00:38:53
IGF-1, those can actually increase serum
00:38:57
glucose and that may not be what you
00:38:58
want if you are someone that is trying
00:39:00
to work on your insulin sensitivity.
00:39:02
>> And do any of these peptides come as
00:39:04
like creams or as pills or anything like
00:39:07
that? If you look online, you can
00:39:09
probably find a version of everything.
00:39:10
But if we're talking about actual
00:39:12
legitimate formulations, the best
00:39:14
example of a topical cream is going to
00:39:16
be GHKCU. And this is interesting
00:39:19
because this is a copper tripeptide that
00:39:21
has been found to decrease in expression
00:39:24
and concentration as we age. But when it
00:39:27
is applied topically, it's highly
00:39:29
effective topically. So putting on a
00:39:31
cream on your face. All right. It's been
00:39:33
found to be extremely beneficial in
00:39:35
regenerating the quality of skin. So,
00:39:37
complexion. All right. Increasing the
00:39:39
amount of collagen and elastin, the
00:39:41
things that we need to keep our faces
00:39:43
taut and youthful. The things that
00:39:45
people will pay lots of money to go get
00:39:47
lasered to get improvements. Not that
00:39:48
it's a replacement for that, but that's
00:39:50
a topical form that believe it or not,
00:39:52
you could go out and buy today because
00:39:54
topical GHKCU is regulated very
00:39:57
differently than the injectable form. Is
00:39:59
it expensive? Usually,
00:40:01
>> you know, growing up, I thought all
00:40:02
these sort of anti-aging creams were
00:40:04
[ __ ]
00:40:05
>> But but you're telling me that this has
00:40:07
actually been associated with improving
00:40:09
signs of aging.
00:40:10
>> I will tell you this, when I was going
00:40:12
through college and medical school, I
00:40:14
was the biggest skeptic. Like, I did not
00:40:16
believe any of the health or wellness
00:40:18
claims that we saw coming out at the
00:40:19
time. And again, you know, that was at a
00:40:21
time where we were getting bombarded
00:40:22
with stuff about the Atkins diet and
00:40:24
this that or the other. But then all of
00:40:25
a sudden you start having patients come
00:40:27
back to you and they're testifying as
00:40:28
the benefits they've seen from these
00:40:30
things. You start to actually look at
00:40:31
the biochemistry behind them and you're
00:40:32
like there's a lot of science backing
00:40:34
this up. This isn't just mumbo jumbo.
00:40:37
And so believe it or not, yeah, there
00:40:39
are creams that can slow the process of
00:40:41
aging at least from a visual standpoint
00:40:43
when it comes to your skin. I have yet
00:40:44
to figure out anything that uh you know
00:40:47
makes me as energetic as I was in my
00:40:48
early 20s, but you know I'm working on
00:40:50
it. Mhm. But on that point of energy and
00:40:52
cognition, if I wanted to become a
00:40:54
better podcaster. Yeah.
00:40:55
>> And you know, I sit here sometimes,
00:40:56
sometimes we do two in a day, which
00:40:58
means I might sit here for eight hours.
00:40:59
Once we do, I think a couple of times
00:41:00
we've done three in a day.
00:41:01
>> That's brutal.
00:41:02
>> Which is 12 hours of recording. Yeah.
00:41:03
>> But what would you recommend if I was
00:41:05
trying to improve my cognitive
00:41:06
performance? So again, as a physician
00:41:08
who likes keeping my license, I wouldn't
00:41:09
say necessarily recommend, but I would
00:41:11
say if we're looking at how these
00:41:13
medications have been used and
00:41:15
potentially one that may be legal again
00:41:17
coming this July depending what the FDA
00:41:19
says, intraasal CAX. And this was one
00:41:22
that was originally studied actually in
00:41:24
Russia many years ago. And what they
00:41:27
found is that this seven amino acid
00:41:29
peptide when it was administered after a
00:41:33
uh TBI, so a traumatic brain injury, all
00:41:35
right, or acute injury, that patients
00:41:38
tended to bounce back faster. Also, they
00:41:40
saw evidence of it improving outcomes
00:41:42
after stroke. And it also seems to
00:41:44
upregulate the same sort of factors that
00:41:46
help with cognition and with, you know,
00:41:49
connecting sentences and bits of data in
00:41:51
your brain. And so it's also one of the,
00:41:53
interestingly enough, one of the ones
00:41:55
that is available, you know, intraasally
00:41:57
because it goes through the mucous
00:41:58
membranes and gets right where you need
00:42:00
it. And so that's going to be a really
00:42:02
really fascinating uh compound to see
00:42:04
back on the market. And then we can
00:42:05
actually get more data regarding
00:42:07
efficacy and across a wide population.
00:42:10
>> So interesting. And you you sniff that
00:42:13
through your nose.
00:42:13
>> Sniff like you would for any nasal
00:42:15
decongestant, right? And if you have
00:42:17
allergies or something like that. Also,
00:42:19
for someone like yourself, you travel a
00:42:21
lot. you know, you're going in between
00:42:22
different time zones, you're balancing
00:42:23
multiple obligations at different odd
00:42:25
times of the day. I I shudder to think
00:42:27
what your circadium rhythm looks like,
00:42:29
my friend. Um, but you know, that is
00:42:30
what we have some of these other
00:42:32
compounds that are uh going to be
00:42:33
available for. So, if we look at uh uh
00:42:37
dip, okay, that has been shown to be
00:42:39
helpful with regulating your circadian
00:42:41
rhythm. All right, that is one of the
00:42:43
ones that's going to be approved
00:42:44
hopefully here soon again in July,
00:42:46
right? And then you know on top of that
00:42:48
um you've got you know uh things like
00:42:50
selen which is another one that can help
00:42:53
calm you as you're going to sleep about
00:42:54
an hour ahead of time and again hope
00:42:56
help those you know deep delta wave
00:42:58
brain waves that are so restorative
00:43:00
whenever you actually are you know
00:43:02
resting.
00:43:03
>> Where will we be able to buy these when
00:43:05
and if they are legalized?
00:43:07
>> So from
00:43:09
uh 503A compounders here in the United
00:43:12
States with a prescription from a
00:43:14
physician.
00:43:14
>> So you still need a prescription. still
00:43:16
need a prescription. Correct. It's
00:43:18
>> going to be quite a crazy world when
00:43:19
everybody seem is going to be injecting
00:43:21
themselves every every day. I mean,
00:43:23
we're already getting to that point now
00:43:24
with the Zen where I've got loads of
00:43:25
people in my my friendship group that
00:43:27
are
00:43:27
>> Yeah. And they're Yeah. And they're
00:43:28
doing great.
00:43:29
>> Yeah. They're doing great.
00:43:30
>> They're doing great. And that's what I
00:43:32
like about, you know, the advent of
00:43:34
these GLP1s is they're removing the
00:43:35
stigma of a needle.
00:43:37
>> And I look at some of my friends who
00:43:39
have been on it. I can't recognize them.
00:43:40
They look awesome.
00:43:41
>> Are you concerned with with any of them?
00:43:44
You know, I've got a couple of friends
00:43:45
in my circle where I'm I'm a little bit
00:43:47
concerned. I don't even know if I should
00:43:49
be concerned, but it's just when you see
00:43:50
someone, you know, change so
00:43:52
dramatically, so quickly.
00:43:54
>> Yeah.
00:43:54
>> I think there's something in us which
00:43:56
something prehistoric in us which goes,
00:43:57
"Oh my god, there's a problem."
00:43:58
>> Yeah. One thing I'm I am concerned about
00:44:01
is the rapid weight loss with GLP-1
00:44:03
medications. Because the problem is is
00:44:05
that when you go into such a radical
00:44:06
caloric deficit, your body goes into
00:44:09
catabolism, which is breaking down
00:44:11
tissue. And you want to break down fat,
00:44:13
right? But your body isn't that
00:44:14
judicious. It's going to break down
00:44:15
muscle. And muscle is the most
00:44:17
metabolically important tissue that any
00:44:19
of us have. And so if you really want to
00:44:21
optimize your insulin sensitivity, well,
00:44:23
you need to maintain your muscle. And
00:44:25
right now, really the only compounds
00:44:27
that we have that are really good at
00:44:28
preserving muscle with resistance
00:44:30
training is testosterone, right? But
00:44:32
that isn't going to be a good option for
00:44:33
our male patients that want to get
00:44:35
pregnant because testosterone turns off
00:44:36
fertility in men. All right? It's also
00:44:38
not a great idea for our female
00:44:40
patients. All right? depending on their
00:44:42
age, testosterone, TRT is a thing in
00:44:44
older, you know, uh, women, menopausal,
00:44:46
won't go into that. But truthfully,
00:44:48
testosterone is not the right answer for
00:44:49
everybody. And so, what we are going to
00:44:52
see come down the pipe very soon is kind
00:44:55
of the older brother of peptides, the
00:44:57
more complex form, biologics, called
00:44:58
monoconal antibodies that are
00:45:00
specifically designed to inhibit the
00:45:03
enzymes that break down muscle. So,
00:45:05
these are specifically called myatin
00:45:06
inhibitors. There are three that are
00:45:08
coming down the uh pipeline. There is
00:45:10
one called bamagrammab which is owned by
00:45:12
lily that is going to bind to the peanut
00:45:15
butter to myastatin jelly which is
00:45:17
called actin. And then you have mab and
00:45:20
travogumab which are two other compounds
00:45:24
owned by a different pharmaceutical
00:45:25
company that are all designed to
00:45:27
maintain muscle even in a significant
00:45:29
caloric deficit.
00:45:30
>> This is getting interesting now.
00:45:31
>> Yeah. Yeah. So you're you're telling me
00:45:33
I'm going to be able to inject myself
00:45:34
with a zmpe to lose the fat and then
00:45:36
inject myself with something else to
00:45:37
keep the muscle.
00:45:38
>> It's wild.
00:45:39
is wild
00:45:42
and and I will tell you, you know, one
00:45:44
of the hardest things that I'm sure
00:45:46
you've heard being on the receiving end
00:45:47
of this is just the complexity of it.
00:45:49
And there are so many levers that are
00:45:51
moving at once and trying to get your
00:45:53
head around it and balance it all. Like
00:45:55
it requires nuance and it requires a
00:45:58
thoughtful discussion with your doctor
00:46:00
who is well educated on them. And that's
00:46:03
one of the challenges is that there
00:46:04
isn't broad great education on these
00:46:06
products right now in the medical space.
00:46:08
And so that's something that I'm very
00:46:10
passionate about is improving education
00:46:12
across my colleagues so that they're not
00:46:15
afraid of these anymore.
00:46:16
>> What do you say to people that are
00:46:17
listening to this now go, "Fucking hell,
00:46:18
why don't you just like eat your greens
00:46:20
and go to the gym?" Yeah.
00:46:21
>> And just be more human and you'll be
00:46:23
fine.
00:46:24
>> I love that. I love eating your greens
00:46:25
and going to the gym. Okay. Um but the
00:46:28
unfortunate reality is that here in the
00:46:29
United States, it depends on what
00:46:32
database you look at, but obesity rates
00:46:34
are estimated to be 40 to 70%. Okay?
00:46:37
whether you depending on what BMI cut
00:46:39
off you're using. Okay, BMI is not
00:46:41
perfect, but it is what it is. And so
00:46:43
the thing is is that well eating greens
00:46:45
and going to the gym are not working for
00:46:47
us as a society. And we could talk about
00:46:49
how we don't have real food anymore. We
00:46:51
have food deserts. We have this nut
00:46:54
calorically dense but nutritionally poor
00:46:56
food. I'll tell you the most disturbing
00:46:58
thing I see as a surgeon is I'll see a
00:47:00
patient come in the door and they're
00:47:02
morbidly obese. They're a large
00:47:03
individual, but I have to do surgery on
00:47:05
them. But the connective tissue, the
00:47:06
stuff that's made up of protein that
00:47:08
makes them them, that literally holds
00:47:09
them together, is paper paper thin
00:47:12
because they're eating an incredible
00:47:13
amount of calories. They're gaining fat,
00:47:14
but they don't have any protein in their
00:47:16
diet. And that's not something that's
00:47:18
rare. I see that on a daily basis. And
00:47:20
so the truth is is that, you know, we're
00:47:22
talking about this from the angle of
00:47:24
biohackers and people that are super
00:47:26
engaged in our health. But the truth is
00:47:28
is that this is going to be able to be
00:47:30
used to help our population at large.
00:47:32
and you know ultimately hopefully avoid
00:47:35
a lot of the terrible disease states
00:47:37
that we're seeing overwhelm the medical
00:47:38
system right now.
00:47:39
>> How big is the peptide industry right
00:47:42
now?
00:47:42
>> If we look at the top four large
00:47:44
language models companies, all right, so
00:47:46
all the heavy hitters and how much
00:47:48
revenue they're generating, it's
00:47:49
estimated between be between 58 billion
00:47:53
up to maybe 62 billion. Yet the income
00:47:56
and the revenue from just simaglutide
00:47:59
and tzepatide alone is going to be over
00:48:02
55 billion this year. And so what we
00:48:05
have is peptides without even
00:48:07
considering all of this happening in the
00:48:08
research space or the research use only
00:48:10
space without even considering the
00:48:12
peptides that uh we'll see come from
00:48:14
compounding pharmacies. We're already
00:48:17
approaching parody with what we're
00:48:18
seeing in AI as far as revenue goes.
00:48:21
That is the demand that we're seeing in
00:48:23
the marketplace. I run multiple
00:48:25
companies that have multiple sales teams
00:48:27
and one of the things as a founder of a
00:48:29
company that's often confusing is you
00:48:31
find it hard to figure out where sales
00:48:32
are. So about 10 years ago I started
00:48:34
using Pipe Drive in my former company
00:48:36
and it's also the reason why I switched
00:48:38
over all of my commercial teams in my
00:48:39
current media company called Steven.com
00:48:41
to use Pipe Drive as well. Not only did
00:48:42
they sponsor this show, but they've been
00:48:44
an incredibly effective way of scaling
00:48:45
our sales engine over the years. Pipe
00:48:47
Drive is an easy to use intelligent CRM
00:48:50
and at its very core it makes your sales
00:48:52
process visible through one dashboard. A
00:48:56
visual pipeline showing every deal, what
00:48:58
stage it's in, what needs to happen
00:49:00
next, and it's all in real time with no
00:49:02
delay. It doesn't magically close the
00:49:04
deal for you, of course, but it does
00:49:06
replace complexity with clarity. If you
00:49:08
want to join over a 100,000 companies
00:49:10
already using Pipe Drive, you can use my
00:49:12
link for a 30-day free trial with no
00:49:14
credit card payment needed. Head to
00:49:16
piperive.com
00:49:19
to get started. That's piperive.comceo.
00:49:23
I'll see you over there.
00:49:25
>> When your patients come and see you, Dr.
00:49:27
Alex, what are they asking you most
00:49:30
frequently as it relates to peptides?
00:49:32
What are like the top three questions
00:49:33
you get asked the most?
00:49:35
>> The first thing I get asked is, "What
00:49:37
peptides do I need?" And then I just
00:49:39
look at them. I'm like, "What's your
00:49:41
problem?" You know, like what's
00:49:42
bothering you?
00:49:43
>> And what do they say? you know, and then
00:49:45
they'll come in and they'll start
00:49:46
talking about energy, sex drive, and
00:49:48
that sort of things. And I'm like,
00:49:49
"Okay, if that's it, well, we need to
00:49:50
check your testosterone levels,
00:49:51
brother." Okay? So, instead of looking
00:49:53
for peptides, right? You know, you don't
00:49:56
walk into a Home Depot or a Lowe's. You
00:49:58
like, "What tools do do I need?" And
00:49:59
you're like, "What are you trying to
00:50:00
do?" Right? And then you start to talk
00:50:02
to someone there like, "Well, I'm trying
00:50:03
to build this." Okay, you need a saw.
00:50:04
You need a screwdriver. You need this.
00:50:05
And some of those tools might be
00:50:07
peptides. All right? But some of them
00:50:08
may be hormones. You know, some of it
00:50:10
may be diet and exercise. And so
00:50:11
peptides are just another type of tool
00:50:13
that we can use.
00:50:14
>> We all want a shortcut though, doctor.
00:50:16
We all want a quick way to to be better
00:50:18
and ideally not to have to do hard work.
00:50:19
That's like what most, you know, the
00:50:20
average person is looking for. And we
00:50:22
hear about these peptides. We hear other
00:50:23
people are taking them. We hear the
00:50:24
fantastic results in skin, hair, muscle.
00:50:26
And we go, "Fucking, what about me?"
00:50:28
>> You know what I tell patients? I'm like,
00:50:29
"Me too, man." You know, but my alarm
00:50:31
still went off at 4:45 this morning so I
00:50:33
could hit the gym before I made it to
00:50:34
clinic. Because there are no real
00:50:36
shortcuts. There are things that can
00:50:38
help, right? GLP-1s are the best example
00:50:40
of that, right? Okay, this is the
00:50:42
closest thing to a shortcut you're going
00:50:43
to get. But the truth is is that this
00:50:45
isn't going to go to the gym for you and
00:50:46
it's not going to lift the weight so you
00:50:47
can maintain that muscle mass so you get
00:50:49
the best possible result and try to hold
00:50:50
on to your muscle while losing the fat.
00:50:52
>> One thing I've learned from doing this
00:50:53
podcast that that has really grown with
00:50:55
me over time. People ask me all the time
00:50:56
like, "What's the one thing you've
00:50:57
learned from the podcast?" One of the
00:50:59
answers that I've never given that I'm
00:51:00
going to give now is that I've learned
00:51:02
that there's no such thing in life as a
00:51:04
free lunch.
00:51:05
>> No, absolutely not.
00:51:06
And what I mean by that is like
00:51:08
everything is a tradeoff. And if you
00:51:11
ever hear on a podcast or in any medium
00:51:14
that something has tremendous upsides,
00:51:17
the first question one should ask is
00:51:19
what's the trade and like just with
00:51:20
everything you can apply this to having
00:51:22
a relationship with a partner. Huge
00:51:23
upsides.
00:51:24
>> Also trade-off.
00:51:25
>> Trade-off. Yeah. Yeah. Kids like
00:51:27
>> I love my children. I haven't slept in
00:51:29
years, right? You know, like this is
00:51:30
just this is this is life, right? There
00:51:32
are trade-offs. And even with great
00:51:34
tools, there are trade-offs. So, what
00:51:35
are the trade-offs of these peptides?
00:51:37
>> The biggest trade-off right now is you
00:51:39
don't know if you're even getting what
00:51:40
you're what you want, right? Because
00:51:42
you're ordering this from some research,
00:51:43
you know, uh, compound only. You don't
00:51:45
know whether or not they've gotten out
00:51:46
all the appropriate endotoxins. You
00:51:47
don't know if you're getting what you
00:51:48
actually paid for. So, that's the
00:51:50
biggest thing. And also, the thing is is
00:51:52
that, well, all right, I these have a
00:51:54
good example of, okay, preventing or
00:51:56
helping heal injury. But the thing is
00:51:59
that well we've got other compounds over
00:52:01
here. You know, let's go ahead and like
00:52:03
let's just pull Tessa Morlin as an
00:52:05
example. So this is actually
00:52:07
interesting. It's a peptide that is
00:52:09
commercially available right now. I
00:52:10
could write the script for you. You
00:52:11
could go pick it up from CVS or
00:52:12
Walgreens. Okay, this is available as a
00:52:14
commercial product and people really
00:52:16
like it because it'll help boost growth
00:52:17
hormone and it happens to be uniquely
00:52:19
good at stripping abdominal fat. Okay,
00:52:21
or visceral fat. But the thing is is
00:52:23
that, you know, the moment you stop
00:52:24
taking it for a brief period of time,
00:52:26
well, if you haven't changed anything
00:52:27
about your lifestyle, you're going to go
00:52:28
right back to where you were.
00:52:29
>> It's good at stripping abdominal fat.
00:52:31
Belly fat.
00:52:31
>> Belly fat. This is what it's known for.
00:52:33
Yeah.
00:52:34
>> It's good at stripping belly fat.
00:52:35
>> Stripping belly fat specifically. So,
00:52:37
bodybuilders actually really like it for
00:52:38
that particular application.
00:52:40
>> I had no idea there was a peptide for
00:52:43
stripping belly fat.
00:52:44
>> There you go, man. You know, and like
00:52:45
for example, here we've got another one.
00:52:47
So, this is melanotan 2, right? So this
00:52:49
is a uh melanoorton receptor agonist. So
00:52:52
melano cortins that's what makes you tan
00:52:54
right? So you could administer this. All
00:52:56
right. And it will actually end up
00:52:58
giving you a deep tan in response to
00:53:01
just a little bit of UV sun exposure.
00:53:03
All right. Now I know right. Um listen
00:53:05
I've embraced my pasty whiteness. So I'm
00:53:07
not you know not necessarily my uh my
00:53:09
bag but it's real. Now again there are
00:53:11
some safety concerns with this because
00:53:13
again could that potentially stimulate a
00:53:14
melanoma or something like that? But
00:53:16
this is something again, it's a peptide
00:53:18
that gives a wildly different result
00:53:20
than Tessa Moralin, right? Because it's
00:53:21
a different tan. It does. Yeah, it does.
00:53:24
It'll also give you um uh some of the
00:53:27
most impressive erections you've ever
00:53:28
had in your life. So, uh be be warned.
00:53:30
Um
00:53:31
>> wait, it's literally turning you into a
00:53:33
black guy.
00:53:34
>> IT DOES.
00:53:36
>> FINALLY. YEAH. RIGHT. And it's wild. So
00:53:38
there's actually and there's even a
00:53:39
derivative a melanotan 2 called PT-141
00:53:44
uh bremalanide that is a commercial
00:53:46
product right now that you can write as
00:53:48
a prescription. Okay. But that doesn't
00:53:51
have the tanning benefit but has the
00:53:53
sexual you know benefits.
00:53:54
>> Oh wow.
00:53:55
>> Yeah.
00:53:56
>> Keep those ones over here.
00:53:57
>> We have to talk about this. Another
00:53:59
really interesting thing that phenomenon
00:54:01
that we've seen right is that now we've
00:54:02
got all of these companies that are
00:54:04
making these research use only
00:54:05
compounds. Right. It used to be that you
00:54:07
would have a compound that's in drug
00:54:08
development and you're seeing all the
00:54:10
advertisements for it. You know, maybe
00:54:11
if you follow these sorts of things like
00:54:12
I do cuz I'm a nerd, right? You get
00:54:14
excited about it, but you don't get
00:54:15
access to it, right? Well, believe it or
00:54:17
not, the next blockbuster drug that Lily
00:54:19
is going to come out with probably in
00:54:21
the next couple of months is this guy
00:54:22
called retatride. All right? And
00:54:24
reatride is fantastic in that it is the
00:54:28
first three receptor agonist GLP-1 drug.
00:54:31
So the GLP-1 drugs, okay, whenever
00:54:33
you're talking about semiglutide and
00:54:35
trazepide, they have slightly different
00:54:37
profiles.
00:54:37
>> This is the ampic category,
00:54:39
>> correct? Right. So GLP-1 is the primary
00:54:42
receptor that they work on. And what
00:54:44
that will do is it slows gastric
00:54:46
emptying and it limits caloric intake.
00:54:48
All right. But then inepathide, not
00:54:51
simaglutide, but tepide is a dual
00:54:53
agonist. So it has effect on GIP, which
00:54:56
is a different receptor. Well,
00:54:58
retatrutide adds in glucagon receptor
00:55:01
activation. And so, believe it or not,
00:55:03
your liver actually acts like a
00:55:05
repository of energy where it stores
00:55:07
glycogen and fat that your body can use
00:55:10
as energy. But that's a problem, right?
00:55:12
If you get too much fat there, if you
00:55:13
have a caloric excess, then you could
00:55:15
end up having what's called nash
00:55:17
cerosis, but non-alcoholic stopatitis.
00:55:20
Basically, inflammation of your liver
00:55:21
due to accumulating too much fat. It's a
00:55:23
problem. But by stimulating the glucagon
00:55:26
receptor while simultaneously hitting
00:55:28
GLP-1 and GIP, what we found is not only
00:55:31
do patients lose an incredible amount of
00:55:33
weight, but they also get the best
00:55:35
improvements we've ever seen in their
00:55:37
liver liver health that we've ever seen.
00:55:38
And people have been buying that from
00:55:41
research use only websites and using it
00:55:44
for about two years now. And
00:55:46
bodybuilders have already made this the
00:55:47
standard in their protocol when it comes
00:55:48
to cutting for a show. And it is wildly
00:55:52
effective. And we're now seeing the
00:55:54
population using a drug at scale that
00:55:57
hasn't even made it through
00:55:59
commercialization yet.
00:56:01
>> Why are you smacking you're using it?
00:56:02
>> No,
00:56:04
I have not. I can honestly say I have
00:56:06
not used Retta, but uh I find it
00:56:08
fascinating though. It's absolutely
00:56:10
wild. You know, talk about power to the
00:56:12
people, right?
00:56:13
>> What about these others then? What else
00:56:14
have we got here that you think is
00:56:15
interesting?
00:56:16
>> So um we've got these two here that I
00:56:18
think are really interesting. So CJC1295
00:56:20
and Morland. So the whole idea is that
00:56:23
you know can we stimulate growth hormone
00:56:25
and there's an interesting story behind
00:56:26
that you know actually growth hormone
00:56:28
itself was very very popular for many
00:56:29
many years as an anti-aging compound but
00:56:32
then we changed some laws here in the 19
00:56:33
in 1990 okay that made it a little dicey
00:56:35
to prescribe growth hormone and also you
00:56:37
know it's kind of a blunt instrument we
00:56:39
wanted something to stimulate more
00:56:40
natural growth hormone release so we
00:56:42
have this entire class of medications
00:56:43
called secrets that help stimulate
00:56:45
natural growth hormone release and these
00:56:46
are two of the most potent ones that are
00:56:48
often combined together
00:56:49
>> and when we say growth hormone Yes.
00:56:51
>> What does growth hormone do?
00:56:53
>> So, growth hormone acts like a signal
00:56:55
that tells your liver to make more of uh
00:56:57
another compound we talked about, IGF-1.
00:56:59
What growth hormone does is growth
00:57:01
hormone actually stimulates building
00:57:03
muscle. Okay? It also strips uh fat.
00:57:07
Okay? And uh it's also been found to
00:57:09
help with tissue healing.
00:57:10
>> Okay?
00:57:11
>> And so there's a significant benefit in
00:57:13
that regard. And so people want to boost
00:57:15
their growth hormone. Improves quality
00:57:16
of skin, improves quality of hair and
00:57:18
nails and that sort of thing. And so uh
00:57:20
these two compounds together are
00:57:22
particularly potent. CJC1295
00:57:25
being a growth hormone releasing uh
00:57:28
hormone derivative and then we have uh
00:57:30
epomoralin which is a ghrein receptor uh
00:57:33
agonist. So again release improving the
00:57:35
release of growth hormone through two
00:57:37
different synergistic mechanisms and so
00:57:39
that one is really really interesting or
00:57:41
these two together and then uh on top of
00:57:43
that so this one sematotropen another
00:57:46
word for growth hormone. Okay. So this
00:57:47
is growth hormone. Okay. Just a
00:57:49
different word for it.
00:57:50
>> So what would happen? Let's just take
00:57:52
this one. Somatropen.
00:57:53
>> Yeah.
00:57:54
>> Somatropen.
00:57:56
If I bought this for research purposes,
00:57:58
>> research purposes only.
00:57:59
>> And I started injecting some of this
00:58:01
into me. What would change?
00:58:03
>> So it depends on how much you do and
00:58:04
when you do it. So the idea is that if
00:58:07
you injected that at night, it would
00:58:09
improve your quality of sleep. Okay. You
00:58:11
would get a boost in your quality of
00:58:14
your hair, your skin, nails. Uh
00:58:16
theoretically it'd be easier for you to
00:58:18
recover from injuries, hopefully put on
00:58:19
a little bit more muscle, a little bit
00:58:20
easier, maybe lose a little bit of fat.
00:58:22
>> So why don't I take it?
00:58:23
>> Well, because if you take a little bit
00:58:24
too much, you can actually get uh
00:58:26
insulin resistance because your glucose
00:58:28
levels will go too high for too long.
00:58:30
All right? You abuse too much for too
00:58:31
long. You will actually get acromegaly.
00:58:33
So that's development of the your bones
00:58:36
continue to grow, but not along only in
00:58:38
certain junctures. And so there's a very
00:58:40
specific look that bodybuilders who
00:58:41
abuse growth hormone in high amounts
00:58:43
will get to them. All right? which is an
00:58:44
irreversible change to the facial bone
00:58:46
structure. You can also theoretically if
00:58:48
you had a cancer maybe it could make it
00:58:50
worse. All right. Um we've never shown
00:58:52
it that it causes new cancers but that
00:58:54
could be a concern. And you know on top
00:58:56
of that it could give you insulin
00:58:57
resistance because you know you're Yeah.
00:58:59
Exactly right. Um and if you take too
00:59:02
much it could potentially make your
00:59:03
hands numb in the morning because you
00:59:04
get eusions into the joint space. And so
00:59:06
bodybuilders will talk about lifting a
00:59:08
dumbbell and having to drop it because
00:59:09
their hand goes numb temporarily if
00:59:10
they're taking too much growth hormone
00:59:11
too soon.
00:59:13
And what else have we got here?
00:59:14
>> Oh my gosh. So, epathylon. So, this is
00:59:18
uh the uh medication that is
00:59:22
theoretically going to be available to
00:59:24
us in uh July. Okay. And so, uh the hope
00:59:27
is that you know this is going to uh
00:59:30
expand cell life. So, epialon the uh
00:59:34
purpose of it is it works to enhance uh
00:59:38
tomeorase. So, at the end of your cells,
00:59:40
imagine it this way. You're trying to
00:59:41
copy the genome, but the little copier
00:59:44
that copies it, it takes up space and of
00:59:46
itself. So, it's kind of like it cuts
00:59:48
off the last couple letters every single
00:59:49
time.
00:59:50
>> This is when you're aging, right?
00:59:51
>> When you're aging, you're creating new
00:59:52
cells, right? Cells divide through this
00:59:54
process called mitosis where they split.
00:59:56
All right? Well, if you got to make an
00:59:57
exact copy, well, you've got to read
00:59:59
through all these lines of code. But
01:00:01
because of the way that we're built, we
01:00:02
always end up cutting off the last
01:00:03
little bit of code. Now,
01:00:04
>> which is how we age,
01:00:05
>> which is how we age. It is one of the
01:00:07
things that contributes to aging. All
01:00:08
right? Now, that is considered to be
01:00:11
quote unquote junk information. It's at
01:00:13
the very end called the telomeir. All
01:00:14
right? But we know that shorter
01:00:16
telomeres are associated with aging,
01:00:18
potentially worse health outcomes. Then
01:00:20
there's an enzyme that can help heal or
01:00:22
repair the telomeir called tomeores.
01:00:25
Epiolon helps encourage that. And so
01:00:28
some people are looking at that as being
01:00:29
one of the fountain of youth uh
01:00:31
compounds. I'm very skeptical as far as
01:00:33
that goes, but it does show some
01:00:35
benefits when it comes to uh, you know,
01:00:37
healing parts of your brain that are,
01:00:38
you know, associated with regulating
01:00:40
your circadian rhythm.
01:00:43
>> So, the average person listening now,
01:00:45
they've heard a lot of stuff about a lot
01:00:46
of things.
01:00:48
How do they know if they should pursue
01:00:52
getting and taking peptides? Like, how
01:00:54
do they know? What are they looking for?
01:00:55
>> So, what I will say is that think of
01:00:58
peptides as falling into three
01:00:59
categories. All right, you've got
01:01:01
category one which are peptides that you
01:01:03
can prescribe right now legal from you
01:01:04
know a commercial pharmacy that includes
01:01:06
the GLP ones PT-141 bremalanide I
01:01:09
mentioned to you earlier oxytocin is
01:01:11
another one we have these different
01:01:12
compounds that are available and then we
01:01:14
have what we call category 2 which we
01:01:16
don't have anything in right now but
01:01:18
that will consist of the seven peptides
01:01:20
that are hopefully going to be approved
01:01:22
in July whenever they get moved from
01:01:24
category 2 cannot compound to category 1
01:01:27
can compound all right and then
01:01:29
everything else is kind of in this
01:01:30
category three where it's only available
01:01:32
for research use only. And so my
01:01:34
recommendation for patients is don't go
01:01:36
out and buy research use only compounds.
01:01:38
All right? You don't know what you're
01:01:39
getting and you don't know if you're
01:01:40
dosing it right. You don't know if it's
01:01:42
contaminated. So really what the public
01:01:44
should be doing is educating themselves
01:01:46
on this and then going and talking to
01:01:48
their doctors about what problems they
01:01:50
have and then potentially when those
01:01:52
options become available, a peptide
01:01:54
might be part of the answer for their
01:01:56
problem.
01:01:57
>> Okay. So speak to your doctor.
01:01:58
>> Yeah. Consult with your doctor and make
01:02:00
it a conver conversation with whoever
01:02:02
your medical professional is about your
01:02:04
symptoms and what might be useful and
01:02:06
what the range the toolbox the options
01:02:08
are correct
01:02:09
>> to attack those symptoms.
01:02:10
>> Yes, absolutely. Talk collaborate with
01:02:13
your doctor. Your doctor should be your
01:02:14
partner in you getting as healthy as
01:02:16
humanly possible.
01:02:18
>> We talked about um tepatide semiglutide.
01:02:22
One of the questions that's front of
01:02:23
mind for everybody, whether they're
01:02:25
taking them or watching others take
01:02:26
them. Sure. Is what happens when you
01:02:28
stop.
01:02:28
>> We've looked at that, you actually
01:02:29
regain the weight. And so, because the
01:02:31
truth is is that you have introduced
01:02:34
something into your life that has moved
01:02:36
the needle in one direction, but if you
01:02:38
don't change anything else, well, you
01:02:40
take that back out, well, you're going
01:02:41
to go back to where you were. And so, if
01:02:43
you're going to maintain that weight
01:02:45
loss, you have to make lifestyle changes
01:02:47
associated with that. And what we found
01:02:48
is that people do regain if they do make
01:02:50
lifestyle changes, they do regain some
01:02:52
of the weight but not necessarily all of
01:02:54
the weight. And there's also data
01:02:56
showing that you could potentially stay
01:02:58
on that medication but at a much lower
01:03:00
dose and then maintain your weight.
01:03:02
Okay. So there are options to minimize
01:03:05
your medication burden long term.
01:03:06
>> And of all the things we've talked about
01:03:08
today, if you had to just pick one thing
01:03:10
that excites you the most that's either
01:03:11
coming down the pipe or here already.
01:03:13
>> Yeah.
01:03:13
>> What is the thing you're most excited
01:03:14
about? I see your eyes wondering. Uh,
01:03:16
hands down it's that one over there,
01:03:17
Redat True Tide, because the changes in
01:03:22
body composition that we have seen both
01:03:24
in clinical trials, okay, and in
01:03:27
anecdotal reports from users who have
01:03:29
obtained on their own are wild. We're
01:03:31
talking losing 20 to 25% of total body
01:03:35
weight within a relatively short period
01:03:38
of time. And I think that this is going
01:03:41
to be basically the Ferrari of GLP1
01:03:45
medications when it comes out. It's not
01:03:46
for everybody, right? It's going to go
01:03:48
faster than everything else, but it's
01:03:50
going to change the game. I think this
01:03:52
is going to be a trillion dollar drug
01:03:55
when it comes out
01:03:56
>> and no one's going to earn the patent,
01:03:57
so everybody will be able to access it.
01:03:58
Is that right?
01:03:59
>> No. No. That is going to belong solely
01:04:01
to Lily. And so you are going to see and
01:04:03
they are going to enforce it you know uh
01:04:06
as aggressively as they've ever enforced
01:04:08
anything but you will see profound
01:04:11
results in patients.
01:04:13
>> People are referring to peptides as
01:04:15
Silicon Valley's miracle drug and I I
01:04:18
wondered why that was why it's been
01:04:19
associated with Silicon Valley. Have you
01:04:20
heard that at all? I have and I'll tell
01:04:22
you I've seen some uh peptide stacks
01:04:24
from you know Silicon Valley you know uh
01:04:27
founders and uh you know uh individuals
01:04:31
that blow my mind. I'm like oh man even
01:04:32
I think that's a lot.
01:04:33
>> Why would pe people in Silicon Valley
01:04:35
why would founders be interested in
01:04:36
peptides?
01:04:37
>> Well I think it's because we all want to
01:04:39
live our you know best version of our
01:04:40
own lives right we want to perform at
01:04:42
the highest level and so you know people
01:04:44
will do whatever they can. They'll drink
01:04:46
caffeine, you know, they'll, you know,
01:04:47
pop a zen in their mouth, you know, and
01:04:49
they'll try to tweak whatever variable
01:04:51
they possibly can to get the best
01:04:52
possible performance. And the thing is
01:04:54
is that anabolic steroids come with, you
01:04:56
know, significant side effects. And
01:04:57
that's not everybody's cup of tea,
01:04:59
right? And the health consequences from
01:05:00
highdose androgens dwarf anything that
01:05:03
you might experience with peptides. And
01:05:04
so peptides offer a lot of flexibility
01:05:06
in pulling many different levers that
01:05:08
are interesting to like your regular
01:05:10
average, you know, person. And honestly,
01:05:12
you know, it requires a little bit of
01:05:14
DIY right now because of the nature of
01:05:16
these peptides. And I think you combine
01:05:19
that with the kind of rogue, you know,
01:05:22
uh founder uh uh spirit that is common
01:05:26
in Silicon Valley and I think it's a
01:05:28
perfect fit.
01:05:28
>> I asked you a second ago, what are the
01:05:30
three questions that people come to you
01:05:31
and ask you as as a doctor? The first
01:05:33
one as it related to peptides was which
01:05:35
peptide should I be taking? Yeah.
01:05:37
>> Are there any other questions we haven't
01:05:38
covered off that are common place in
01:05:40
your practice? The second one is, you
01:05:42
know, can you prescribe me? And then I
01:05:44
have to explain to them the regulatory
01:05:45
environment, you know, surrounding
01:05:46
peptides that, you know, as of right
01:05:48
now, the only peptides that I can
01:05:49
prescribe are the ones you can get from
01:05:51
CVS or Walgreens, which is going to be
01:05:53
your GLP-1 medications, and a handful of
01:05:55
others that usually aren't applying to
01:05:57
the young men that I see in my practice.
01:05:59
I've had so many founders speak to me
01:06:01
and say, "Why didn't this particular ad
01:06:03
that I ran on this platform work for me?
01:06:05
Maybe the copy wasn't good, the creative
01:06:07
wasn't strong, but usually the problem
01:06:08
is they're not having the right
01:06:09
conversation because that ad never
01:06:11
reached the right person. And if you're
01:06:13
in B2B marketing, that is much of the
01:06:15
game. And this is where LinkedIn ads
01:06:17
solves that problem for you. Their
01:06:19
targeting is ridiculously specific. You
01:06:21
can target by job title, seniority,
01:06:24
company size, industry, and even
01:06:26
someone's skill set. And their network
01:06:28
includes over a billion professionals.
01:06:30
About 130 million of them are decision
01:06:33
makers. So, when you use LinkedIn ads,
01:06:35
you're putting your brand in front of
01:06:36
the right people. And LinkedIn ads also
01:06:38
drive the highest B2B return on ad spend
01:06:41
across all ad networks in my experience.
01:06:43
If you want to give them a try, head
01:06:45
over to linkedin.com/diary.
01:06:48
And when you spend $250 on your first
01:06:50
LinkedIn ads campaign, you'll get an
01:06:52
extra $250 credit from me for the next
01:06:56
one. That's linkedin.com/dary.
01:06:59
Terms and conditions apply.
01:07:01
We have finally caved in. So many of you
01:07:04
have asked us if we could bundle the
01:07:06
conversation cards with the 1% diary.
01:07:08
For those of you that don't know, every
01:07:10
single time a guest sits here with me in
01:07:11
the chair, they leave a question in the
01:07:13
diary of a CEO and then I ask that
01:07:15
question to the next guest. We don't
01:07:17
release those questions in any
01:07:18
environment other than on these
01:07:20
incredible conversation cards. These
01:07:22
have become a fantastic tool for people
01:07:24
in relationships, people in teams, in
01:07:26
big corporations, and also family
01:07:28
members to connect with each other. With
01:07:30
that, we also have the 1% diary, which
01:07:32
is this incredible tool to change habits
01:07:33
in your life. So many of you have asked
01:07:36
if it was possible to buy both at the
01:07:38
same time, especially people in big
01:07:40
companies. So, what we've done is we've
01:07:42
bundled them together and you can buy
01:07:44
both at the same time. And if you want
01:07:45
to drive connection and instill habit
01:07:48
change in your company, head to the
01:07:49
diary.com to inquire and our team will
01:07:51
be in touch. Is there a super peptide
01:07:54
for anti-aging in skin and some of those
01:07:57
issues?
01:07:57
>> Oh, for skin, GHKQ. So it's key.
01:07:59
>> Yeah. So this is, you know, uh probably
01:08:02
the most well-known peptide for uh use
01:08:05
for skin complexion and uh I mean really
01:08:08
it may have some small benefits when it
01:08:10
comes to hair. All right. But th those
01:08:12
reports are a little bit more spotty.
01:08:13
>> Okay.
01:08:14
>> Yeah.
01:08:14
>> And then outside of the world of
01:08:15
peptides for a second. Yeah.
01:08:17
>> I've got these three vials in my hand.
01:08:20
>> I'm so scared.
01:08:21
>> All right.
01:08:24
Do you know what those are?
01:08:26
>> Oh, yeah. Uh this is uh unfortunately
01:08:30
our future if we're not careful.
01:08:32
>> Explain.
01:08:33
>> So you know what we've got here is we
01:08:35
have uh three different uh canisters
01:08:38
containing water that has a little bit
01:08:41
of coloring in it. And what you can see
01:08:43
is that all the way back in 1973, this
01:08:45
is pretty opaque. All right? Like you
01:08:47
know this is not uh what you would you
01:08:49
can't see through it. And then 2026 has
01:08:51
a little bit of color to it. And then
01:08:53
we've got over here 2045 which is
01:08:55
totally uh clear. Uh this unfortunately
01:08:58
is actually representing the fertility
01:09:01
trajectory for young men because what
01:09:03
we're seeing is that back in 1973 total
01:09:07
modal sperm count so how many healthy
01:09:09
swimming sperm do we have in each
01:09:10
ejaculation is exponentially higher and
01:09:13
more dense than what we're seeing today.
01:09:15
And so what we're seeing is a
01:09:17
progressive decline in male fertility
01:09:19
over time. And that's been demonstrated
01:09:21
in multiple studies. We've debated this
01:09:22
at multiple meetings. People tried to
01:09:24
argue that it's a measuring difference.
01:09:25
But as we give it more time and as we
01:09:28
give it more scrutiny, this is real. We
01:09:30
are experiencing a significant decline
01:09:32
in uh sperm quality and motility and
01:09:35
concentration.
01:09:37
>> Why? So the leading culprits are going
01:09:41
to be yes microplastics and
01:09:44
environmental toxins. Okay, things that
01:09:46
are put in our environment that we have
01:09:48
been exposed to that we can't help. But
01:09:50
again, the biggest modifiable risk
01:09:52
factor is insulin resistance and
01:09:54
metabolic disease,
01:09:55
>> obesity,
01:09:56
>> obesity. And so a downstream effect that
01:09:59
we may see from peptides like we
01:10:02
discussed before is we may be able to
01:10:04
help reverse this for the first time in
01:10:06
history by trying to prevent the
01:10:08
development of metabolic disease
01:10:10
>> using some of the peptides we talked
01:10:11
about earlier.
01:10:11
>> Exactly. I gave you the example of a
01:10:13
patient that I saw in clinic this past
01:10:14
week that increased his sperm count 10
01:10:16
times over. Imagine if we had given that
01:10:18
to him before he even got that obese
01:10:20
when he just started to get a little bit
01:10:21
overweight and at a lower dose. Well, he
01:10:24
may have never ended up in my office,
01:10:25
right? Because his primary care doctor
01:10:26
would have identified that, treated it,
01:10:28
and he never would have needed the
01:10:29
specialist.
01:10:32
It's crazy. It's wild.
01:10:35
So ultimately you know if you look at
01:10:39
what are the ills that are affecting
01:10:40
health care in you know any first world
01:10:43
nation uh the number one offender is
01:10:46
metabolic disease and metabolic
01:10:48
dysfunction and this is something that
01:10:50
was actually hinted at you know by you
01:10:52
know RFK whenever he was talking about
01:10:55
uh root cause of disease. Well, yes, we
01:10:58
have many many diseases and many many
01:11:00
infections that don't stem necessarily
01:11:02
from insulin resistance. But if we look
01:11:03
at cardiac disease, if we look at issues
01:11:06
with lack of profusion, my my specialty,
01:11:09
erectile dysfunction, right? We look at
01:11:11
cancer, all of this is related back to
01:11:13
obesity and metabolic dysfunction. And
01:11:15
so if we can eliminate that, you know,
01:11:17
as a society, or we can minimize it to
01:11:19
as little as possible, well, I mean,
01:11:21
man, maybe I'd finally work myself out
01:11:22
of a job.
01:11:24
>> Your specialtity is erectile
01:11:25
dysfunction.
01:11:26
>> Yeah. So my specialty is this branch off
01:11:29
of urology that we broadly call men's
01:11:31
health. Okay? And so what that
01:11:33
incorporates for us is going to be low
01:11:35
testosterone, advanced hormone
01:11:36
management. I take that a little bit
01:11:37
further than most people. That's totally
01:11:39
cool. And then also uh erectile
01:11:41
dysfunction, peronis disease, which is
01:11:43
damage to the penis that causes
01:11:44
curvature. And then uh male fertility on
01:11:47
top of that. And I do a little other
01:11:50
thing uh treating leakage after uh
01:11:52
prostate cancer treatment. And that's
01:11:54
basically it. I treat like five things
01:11:56
maybe and you know that's it. So I'm
01:11:59
very very specialized because I was the
01:12:02
kid that you know like to take my
01:12:03
sandwiches apart and eat it one at a
01:12:04
time. I was very precise and I figured
01:12:06
you know you can do a lot of things in
01:12:08
this world and be okay at them or you
01:12:09
can pick like I don't know four or five
01:12:10
and get pretty good at them. So that
01:12:12
seemed to work for me.
01:12:14
>> I was looking at a photo of you 5 years
01:12:16
ago and you were very different.
01:12:18
>> Yeah.
01:12:18
>> You've changed a lot. So,
01:12:21
I will
01:12:24
I will tell you this. Um,
01:12:28
medical training
01:12:30
in the United States has gotten better,
01:12:33
but it is grueling. It's absolutely
01:12:36
grueling.
01:12:38
For 5 years, I worked anywhere from 80
01:12:41
to 100 hours a week in a hospital.
01:12:44
No eating, very little sleep, did not
01:12:47
care for yourself at all. Um, and again,
01:12:50
we can argue whether or not that's
01:12:52
necessary all day long, but the truth is
01:12:54
is that it really beat me down. It
01:12:58
absolutely took me apart physically and
01:13:01
psychologically.
01:13:03
In part, it's designed to do that
01:13:05
because the idea is that as a surgeon,
01:13:07
you have to be able to perform when all
01:13:10
the lights are on, when everything is
01:13:12
against you. You have to be the one to
01:13:13
hold it together in the operating room
01:13:15
and command that ship and save that
01:13:16
patient.
01:13:18
And I remember being totally devastated
01:13:22
towards the end of training and I did a
01:13:25
very challenging surgery on a very needy
01:13:28
patient. Gentleman was about to go into
01:13:30
renal failure. Did not have a lot of
01:13:31
kidney left and he had a very
01:13:34
challenging kidney tumor that was in a
01:13:37
very treacherous location. It was in a
01:13:39
location where he should have lost that
01:13:41
kidney by all measure if we were going
01:13:43
to take out that cancer. And he was at a
01:13:46
county hospital. He had no insurance,
01:13:49
you know, and we swung for the fences
01:13:52
and did a very, very challenging
01:13:53
operation on him. And against our best
01:13:57
efforts with having everybody there, he
01:13:59
ended up having a bleed postoperatively
01:14:02
that night. And I remember getting the
01:14:04
call, I was on call, and that his blood
01:14:07
pressure had dropped and that he did not
01:14:09
look well. And I knew exactly what it
01:14:10
was because, again, this was a very
01:14:12
treacherous surgery. And I went in in
01:14:15
the middle of the night with my
01:14:16
attending, who was a different
01:14:17
attending, than the one I did the
01:14:18
initial surgery with. And I remember
01:14:20
just opening him up
01:14:23
and just
01:14:25
being covered in blood that we were
01:14:27
taking out of the abdominal field that
01:14:29
we were evacuating, eventually
01:14:31
identifying the area of the bleed, and
01:14:33
there was no way that it could have been
01:14:34
avoided. I remember my attendant yelling
01:14:36
at me and we ultimately had to take that
01:14:38
guy's kidney. And
01:14:41
I remember
01:14:43
walking out of there just being totally
01:14:45
shattered, covered in blood, crying in a
01:14:47
hallway by myself, wondering if, you
01:14:50
know, like what what was the point? Like
01:14:52
is there going to be is there a tomorrow
01:14:53
after this? Like I spent all this time
01:14:54
in this training like am I good enough?
01:14:56
Am I going to be able to make this? And
01:14:59
you know, I wasn't well put together,
01:15:01
wasn't healthy. Uh and I ended up
01:15:04
spending a lot of time with that
01:15:05
patient. literally held his hand
01:15:06
throughout the rest of his hospital stay
01:15:08
and he ended up recovering uh and uh
01:15:11
against all odds. But you know
01:15:13
afterwards I took a strong interest in
01:15:17
not only taking care of my patients but
01:15:20
also
01:15:22
practicing what I preach taking care of
01:15:24
myself and prioritizing my own health. I
01:15:27
got evaluated. I was diagnosed with low
01:15:28
testosterone myself. Turns out not
01:15:30
eating or sleeping for 5 years will do a
01:15:32
number on you.
01:15:33
>> All stress
01:15:34
>> through the roof 24/7. I cannot even
01:15:38
imagine what you know there's a part in
01:15:40
the brain called the hippocampus that
01:15:42
they when they do MRIs on soldiers that
01:15:45
come back from war that'll be
01:15:47
degenerated in them. I wonder if we did
01:15:49
that in surgical trainee what that would
01:15:51
look like. But I made a commitment to
01:15:55
take care of my patients, to take care
01:15:57
of myself and make that a priority and
01:16:01
uh to be you know simultaneously the
01:16:03
best doctor and you know the best father
01:16:04
and you know husband that I could be.
01:16:06
Not perfect made a lot of mistakes along
01:16:08
the way but you know what you're seeing
01:16:10
from 5 years ago is where I was. You
01:16:13
know, I've been in training out for
01:16:14
seven years, so it took a while to kind
01:16:15
of recover from that. But what you're
01:16:16
seeing is, you know, what focusing on
01:16:19
health and wellness can potentially look
01:16:20
like.
01:16:22
The emotion in you is palpable when you
01:16:24
talk about this. And I'm wondering where
01:16:27
that comes from. What is it? Cuz you're
01:16:29
looking off into the distance at
01:16:31
something. And I don't know what you're
01:16:33
looking at.
01:16:34
>> Yeah. I mean,
01:16:38
I
01:16:40
when I'm caring for my patients and I
01:16:43
see a young man that is struggling with
01:16:46
his fertility and he wants to be a
01:16:48
father,
01:16:50
I was that guy. Me and my wife couldn't
01:16:53
get pregnant when we first tried. We
01:16:55
ended up having to do in vitro
01:16:56
fertilization at IVF. I remember feeling
01:16:59
like I wasn't a man because I was
01:17:01
sitting in that room holding her hand
01:17:02
and not having an answer as to why
01:17:04
things weren't working. Um, when I see
01:17:07
my patients who come in that are, you
01:17:09
know, struggling because their hormones
01:17:11
are out of whack and no matter how they
01:17:13
try to take care of themselves,
01:17:14
something just isn't clicking.
01:17:16
I've been that guy. And then when I see
01:17:19
my other patients, you know, that are
01:17:20
further on in life and struggling with
01:17:22
things like, you know, prostate cancer
01:17:24
or erectile dysfunction, whatever the
01:17:25
case may be, I see like I see my my my
01:17:28
father, my uncle, my grandfather. I like
01:17:30
these but and they are someone's father,
01:17:33
grandfather and uncle. like these are
01:17:35
our brothers and this is who I have been
01:17:38
called to care for and I care for my
01:17:40
patients deeply and it's because I care
01:17:43
for my patients and like this is a
01:17:45
calling for me that I care about stuff
01:17:47
like this because I want my patients to
01:17:50
have every tool physically possible to
01:17:52
live their best quality of life so that
01:17:54
they can be whole and they can be happy
01:17:56
and so that they can be the best version
01:17:58
of themselves for their loved ones.
01:18:07
Well, thank you for caring because it
01:18:09
matters and uh a lot of this stuff is
01:18:12
quite opaque and confusing to an average
01:18:14
person like me, but it's glad I'm so
01:18:16
glad that we have people out there in
01:18:17
the world like you that are demystifying
01:18:19
all of this for us and explaining it in
01:18:21
simple terms, but also championing it
01:18:22
because, you know, one of the things
01:18:24
other things I've learned from doing
01:18:25
this podcast is solutions to problems
01:18:27
that a lot of people are suffering with
01:18:28
are option right in front of us, but
01:18:30
they need voices and educators like
01:18:31
yourself out there um leading the charge
01:18:34
so that these types of things are
01:18:35
available to everyone, not just the few.
01:18:38
>> Absolutely.
01:18:38
>> Not just the billionaires who can get
01:18:40
whatever they want straight away, any
01:18:41
day.
01:18:42
>> Yeah. I mean, you know, it's uh one
01:18:45
thing I I love is that I've I've been
01:18:48
very blessed in my practice to take care
01:18:50
of people that are much fancier than I
01:18:51
am and sit in boardrooms and that sort
01:18:52
of thing. But, you know what? I love
01:18:55
taking care of my my regular patients
01:18:58
who are, you know, farmers, iron
01:19:01
workers, you know, tradesmen, guys that,
01:19:03
you know, truthfully I have more in
01:19:05
common with than anyone else. You know,
01:19:07
I joke with my patients, I'm just an
01:19:08
over educated plumber at the end of the
01:19:10
day, right? Urologist. And so, um, it's,
01:19:13
uh, health is for everyone, not just for
01:19:16
the fortunate.
01:19:17
>> The last thing I wanted to talk to you
01:19:18
about is linked but random.
01:19:20
>> Yes,
01:19:21
>> it's the enhanced games. Let's do it. I
01:19:26
I am so excited about these. So, um,
01:19:28
>> do you know them?
01:19:29
>> I do very well. So, for those of you or
01:19:32
for for those who may not know, the
01:19:34
enhanced games is a project based off of
01:19:38
the world anti-doping ay's own data.
01:19:41
Potentially up to 40% of athletes that
01:19:43
are competing at the Olympic level have
01:19:45
either are currently using or have used
01:19:47
banned substances at some point in time.
01:19:49
All right. And also, we know that a lot
01:19:51
of the compounds that are used for
01:19:53
enhancement maybe aren't quite so
01:19:55
dangerous if they're being administered
01:19:57
by a trained medical professional with
01:19:58
proper oversight. And as of right now,
01:20:00
that's not happening. Also, at the same
01:20:02
time, we know that Olympic athletes
01:20:05
aren't paid enough, right? These are the
01:20:07
best of the best of the best and they're
01:20:08
not even making the poverty line a lot
01:20:10
of years. And so, the idea is this.
01:20:12
Well, what if we go ahead and we strip
01:20:14
away those rules? Okay, we allow
01:20:16
athletes to use medications that can
01:20:18
enhance performance. We watch them very
01:20:20
closely and we have a team of doctors
01:20:21
and medical prof medical professionals
01:20:23
watching them and then let's see what
01:20:26
they can do at these traditional Olympic
01:20:28
events and see if they smash world
01:20:30
records. Oh, and they're going to give
01:20:32
250 grand to any first place winners and
01:20:34
a million dollars to anyone that hits a
01:20:36
world record.
01:20:37
>> And just for comparison, how much are
01:20:39
Olympic athletes getting paid?
01:20:41
>> They don't get paid to compete at all.
01:20:43
Okay, so they don't get paid to be an
01:20:44
Olympic athlete. they uh end up getting
01:20:47
sponsorship deals and that's potentially
01:20:48
the money that they can make. So
01:20:51
>> yeah,
01:20:51
>> interesting. So it's basically the
01:20:53
doping Olympics where everyone's allowed
01:20:54
to dope.
01:20:55
>> That's the idea. There's some caveats in
01:20:57
there. They're trying to say that only
01:20:59
FDA approved medications can be used.
01:21:01
Okay. So you couldn't use something like
01:21:02
Trenbolone, which is for veterinary use
01:21:04
only um or theoretically any of the
01:21:07
compounds we've talked about today
01:21:08
because they're not FDA approved. But
01:21:09
also at the same time, they've said that
01:21:11
they're not going to test for those
01:21:12
things. and one of their athletes, uh,
01:21:14
Magnus, has openly admitted to taking
01:21:16
BPC 157 and that sort of thing. So, I
01:21:19
think we can kind of figure out that it
01:21:20
may just be a wide openen playing field,
01:21:22
maybe. So,
01:21:24
>> the International Olympic Committee does
01:21:26
not pay athletes a single cent for
01:21:28
winning a gold medal.
01:21:30
>> Yep.
01:21:30
>> Which is crazy.
01:21:31
>> How many billions do you think they make
01:21:33
off of those with all the advertisement?
01:21:35
>> So much money,
01:21:36
>> right? Yeah. And this is taking place in
01:21:39
Las Vegas
01:21:40
>> May 21st through the 24th, I believe.
01:21:42
>> Are you going to go?
01:21:43
>> I'm going to be watching, that's for
01:21:45
sure.
01:21:45
>> Do you want to go?
01:21:46
>> I would love to go. That would be
01:21:48
incredible.
01:21:49
>> Well, if you want to go, I know a few
01:21:50
people that are that are putting the
01:21:52
event on, so do let me know.
01:21:54
>> I'm there, man. I'm already interested.
01:21:55
You got my got my attention.
01:21:57
>> Is there anything else we should have
01:21:58
talked about that we didn't talk about
01:21:59
as it relates to this subject we've
01:22:01
discussed today?
01:22:02
>> I mean, honestly, I think that we've
01:22:03
gone pretty deep on peptides. And so I
01:22:06
think we've, you know, uh, covered uh,
01:22:08
that, but one thing that I did want to
01:22:12
just, uh, I'll leave with you cuz I
01:22:14
think it's pretty humorous and I think
01:22:15
you've talked to some of my colleagues
01:22:16
about this before, but you know, one of
01:22:18
the things that I deal with as a
01:22:19
surgical specialist is the endstage of
01:22:21
vascular disease, the endstage of
01:22:23
diabetes, which is going to be erectile
01:22:25
dysfunction. All right? And, you know,
01:22:27
believe it or not, whenever we're
01:22:29
dealing with that in male patients, they
01:22:31
eventually get to a point where things
01:22:32
like Viagra and Seialis do not work. All
01:22:34
right? And that is a dark place to be as
01:22:36
a guy. And so you're taking these
01:22:38
medications, all you're getting is a
01:22:39
headache and nothing else. And then
01:22:41
maybe you have other options. They're
01:22:43
actually injections you can do in the
01:22:44
penis, which is about as appetizing as
01:22:46
you might imagine. But men want a better
01:22:49
solution. And they'll come to us as
01:22:51
sexual medicine specialists, you know,
01:22:53
seeking that. And that's what I do. So
01:22:55
the bulk of my surgical practice is
01:22:57
actually fixing erectile dysfunction
01:22:59
with a procedure called implant
01:23:01
placement. Okay.
01:23:01
>> Oh, no.
01:23:02
>> Absolutely. So now I think did Reena
01:23:05
show you one of these last time?
01:23:06
>> She brought it and I didn't I didn't ask
01:23:08
her to show me. It makes me like I get
01:23:10
full body shuddters when I hear about
01:23:12
this stuff. Yeah. The thought of putting
01:23:13
that up my penis.
01:23:14
>> Well,
01:23:15
>> you can show me. No, you can show.
01:23:16
>> Well, I would tell you the good news is
01:23:17
is you don't have to. Okay. Like that's
01:23:19
that's what we have a job for. Okay. But
01:23:21
the way I explain to patients is like
01:23:23
this. So take this out of out of the
01:23:25
picture. Okay. Ultimately like the male
01:23:27
erection is just two inflatables tubes
01:23:29
that start in the pelvis and go out the
01:23:30
shaft of the penis. It makes sense,
01:23:32
right? It is a hydraulic motion. What
01:23:35
happens is you get stimulated, get a
01:23:36
rush of blood into those tubes, get a
01:23:38
rigid erection, able to use that for
01:23:39
intimacy, and then when you climax, pop
01:23:41
off valve opens back up and everything
01:23:42
drains out. All right? So, if you can
01:23:44
understand brakes on a car, you can
01:23:45
understand erections. But the problem is
01:23:46
that when you have long-term metabolic
01:23:48
and vascular dysfunction, the brake
01:23:50
lines, the blood vessels that feed those
01:23:52
erections, they fail. And all of a
01:23:54
sudden, you can't get enough blood flow
01:23:55
for it to work. And believe it or not,
01:23:57
you can actually get atrophy of the
01:23:58
penis over time, and you actually lose
01:24:00
size. All right, which no man is eager
01:24:03
to see. All right, but whenever the easy
01:24:06
things like oral medications, Viagra and
01:24:08
Seals don't work anymore, the next best
01:24:10
option if we're looking at patient
01:24:12
satisfaction, durability, concealability
01:24:14
is this little thing that I do, which is
01:24:17
what if we took our own tubes, okay, and
01:24:20
we put them inside your body's natural
01:24:22
ones. It's invisible. Nobody looking at
01:24:24
you could ever tell that you've ever had
01:24:25
anything done. But all of a sudden, when
01:24:27
you want to get an erection, instead of
01:24:28
having to rely on pills that don't work
01:24:30
or putting a needle in there, right, you
01:24:32
could reach down and there's a small
01:24:33
pump that we hide underneath the skin
01:24:35
down in the scrotum. Okay? So, I joke
01:24:37
it's like a third testicle, but again,
01:24:38
nothing external, nothing you can see.
01:24:40
And all of a sudden, whenever you
01:24:41
squeeze this, what it does is it moves
01:24:43
saline that we hide in a little
01:24:45
reservoir that goes in the belly. You
01:24:47
never feel that into the cylinders. And
01:24:49
all of a sudden, men are able to get a
01:24:52
firm, rigid erection that looks natural,
01:24:54
feels natural, and they can use it as
01:24:56
long as they want or until their
01:24:57
partner's sick of them, and then press a
01:25:00
button and it goes back down.
01:25:01
>> Do they still feel the same pleasure?
01:25:03
>> Yeah. So, it does not affect sensation.
01:25:05
And so, the nerves that affect sensation
01:25:08
run along the top of the penis if you're
01:25:10
looking at a clock at the 12:00
01:25:11
position. And we stay totally away from
01:25:14
those. So, this is surgically put inside
01:25:18
the penis.
01:25:18
>> All internal. And believe it or not,
01:25:20
that takes me about 13 minutes to do.
01:25:22
>> How many people have these?
01:25:24
>> Well, uh, I've put in about 11 or,200
01:25:27
personally, but
01:25:28
>> 11 or,200.
01:25:29
>> Yeah.
01:25:29
>> Okay. So, it's quite a lot of people.
01:25:30
There'll be people listening now that
01:25:32
have these.
01:25:32
>> Well, you know, this is what's
01:25:33
interesting. If you look at in the
01:25:34
United States right now, okay, there are
01:25:37
30 million men with erectile dysfunction
01:25:38
in the United States right now. That's
01:25:40
more than the population of Australia.
01:25:42
All right.
01:25:42
>> Oh, wow. And if you look at statistics,
01:25:44
the oral medications are going to fail
01:25:46
in 15 to 40% of those men the first time
01:25:48
they fail that. And so you're talking
01:25:50
about millions and millions of men who
01:25:52
aren't responding to oral medications
01:25:53
and need a better option.
01:25:55
>> So where's the button to get rid of the
01:25:57
erection?
01:25:57
>> You see those two little bars right
01:25:58
there?
01:25:58
>> These two.
01:25:59
>> Yep. Go ahead and put your thumb on.
01:26:01
Yep. Do that. And then squeeze from the
01:26:04
end of the device back uh towards the
01:26:06
pump.
01:26:06
>> So squeeze.
01:26:07
>> Yep. Right there. There you go. It's
01:26:09
down.
01:26:12
And then you would have the weight of
01:26:13
your natural tissue push things down.
01:26:16
>> Okay. And then Yeah. Okay.
01:26:17
>> There you go.
01:26:18
>> Okay. Okay. Well, you know, I'm I'm
01:26:21
happy people have the options because I
01:26:22
can imagine what that would be like to
01:26:24
not be able to get an erection. It would
01:26:26
be devastating, frankly.
01:26:27
>> Well, I'll tell you this. I get more
01:26:28
hugs and high fives than anybody else in
01:26:30
my practice. And that includes the guys
01:26:31
that treat kidney stones and cancer. So,
01:26:33
I feel like you're doing some doing some
01:26:34
good work here until Peptides put me out
01:26:36
of business.
01:26:38
>> I don't think that's going to happen
01:26:39
anytime soon. And you have a great
01:26:40
YouTube channel.
01:26:41
>> Thank you. I appreciate that. Which I
01:26:42
think everybody should go check out
01:26:44
because you really are great at at
01:26:45
explaining all this stuff in simple
01:26:46
terms. So, I'm going to link uh Dr.
01:26:48
Alex's YouTube channel down below. We'll
01:26:50
try and collab. So, if you just click on
01:26:52
the Dio icon now, you'll see Alex's
01:26:54
channel. And I highly recommend you go
01:26:56
check out his content because he's
01:26:57
really really leading the charge on this
01:26:59
subject of peptides. When I spoke to my
01:27:01
team and said, I want to have a
01:27:02
conversation about peptides. They gave
01:27:03
me lots of options of lots of different
01:27:05
types of doctors and uh you were by far
01:27:07
and away our preference because of the
01:27:09
very fact that you're very very good at
01:27:11
communicating. You understand people and
01:27:12
as you've demonstrated today, you have a
01:27:13
very big heart.
01:27:14
>> I appreciate that.
01:27:15
>> And you're clearly it's it was wonderful
01:27:16
to see what's actually driving you. Um
01:27:18
and you did that in a way which um is
01:27:20
irrefutably authentic. So please go
01:27:23
check out Alex's channel. Um he's around
01:27:25
you're around 100,000 subscribers on
01:27:27
that channel now.
01:27:27
>> I'm so close. We're at like 98.99 any
01:27:30
minute now.
01:27:31
>> Okay. So hopefully we can help push you
01:27:32
over um that
01:27:36
that milestone.
01:27:37
>> Yeah.
01:27:38
>> We have a closing tradition, Alex, on
01:27:39
this podcast where the ask us leaves a
01:27:41
question for the next, not knowing who
01:27:42
they're leaving it for.
01:27:42
>> Okay.
01:27:43
>> Question left for you is if you could
01:27:46
give
01:27:47
$1 billion to one person you don't know
01:27:51
personally, who is it
01:27:54
and what do they have to spend it on?
01:27:58
Uh,
01:28:00
honestly, I would give it to Elon Musk,
01:28:05
okay?
01:28:06
>> And it's not because I think that he's
01:28:09
hurting for a billion dollars right now,
01:28:11
but if you look at what he is working on
01:28:15
to accomplish for us as a human race,
01:28:18
right? He I truly believe from what I've
01:28:21
seen that he has a similar heart for
01:28:23
humanity that I've seen with a lot of
01:28:25
physicians. But on a macro scale as an
01:28:28
engineer and an entrepreneur, he's
01:28:30
trying to solve some of the greatest
01:28:31
problems that are facing us today. And I
01:28:34
think that what we are going to see
01:28:36
hopefully coming from the uh Terrafab
01:28:38
down in Austin is going to be wild with
01:28:41
recursive uh feedback and engineering on
01:28:44
AI chips that are going to get better
01:28:46
and better and better in a short period
01:28:47
of time and increasing, you know,
01:28:49
independence when it comes to, you know,
01:28:51
chip foundaries for the United States.
01:28:53
like it's wild and I think that that
01:28:57
billion dollars would go further and do
01:28:59
more for more people than anywhere else
01:29:01
I could put it.
01:29:02
>> And he's also working on Neurolink which
01:29:03
is really interesting company which puts
01:29:05
uh sort of brain chip interfaces to
01:29:07
allow people to
01:29:10
hear again, see again, allow paraplegics
01:29:12
to walk again. Um which is
01:29:14
>> really really incredible. Dr. Alex,
01:29:16
thank you so much. It's so illuminating
01:29:18
and I can't wait to have you back again
01:29:19
sometime soon to talk about all the
01:29:20
other things we could have talked about
01:29:21
today. We focused on peptides
01:29:23
predominantly, but I know that over on
01:29:24
your YouTube channel, you talk about a
01:29:25
lot more than that. So, highly recommend
01:29:27
everybody go check out Dr. Alex's
01:29:28
YouTube channel. And uh it's been a
01:29:29
pleasure. Thank you.
01:29:30
>> Thank you, Stephen.
01:29:31
>> YouTube have this new crazy algorithm
01:29:32
where they know exactly what video you
01:29:35
would like to watch next based on AI and
01:29:37
all of your viewing behavior. And the
01:29:39
algorithm says that this video is the
01:29:42
perfect video for you. It's different
01:29:44
for everybody looking right now. Check
01:29:45
this video out and I bet you you might
01:29:47
love
