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Investigators Couldn’t Identify the Poison at First... #maryyoder #truecrimestories #crimejunkies

March 22, 2026 / 02:13

This episode discusses the mysterious death of Mary, who died from an overdose of colchicine, a drug typically used to treat gout. The investigation into her death reveals that colchicine is not commonly known, and it raises questions about how it entered her system.

Dr. Clark tests for common poisons like arsenic and cyanide, but when results come back negative, he collaborates with poison control to identify the cause of Mary's symptoms. After nearly two months, they determine that colchicine was the culprit.

Mary was an avid gardener, leading investigators to consider if she accidentally ingested colchicine from plants. However, they also explore the possibility of contamination from the supplements she regularly took, which could pose a public health risk.

Ultimately, investigators check both her garden and her supplements, but everything returns clean, leaving the mystery of how she ingested such a lethal dose unresolved.

TLDR

Mary died from colchicine overdose, raising questions about contamination and accidental ingestion.

Episode

2:13
00:00:00
So, Dr. Clark tests for all the usual poison suspects, right? Like arsenic, cyanide. But when those come back
00:00:07
negative, he works with poison control resources trying to match Mary's symptoms
00:00:12
to something in their database. And this stretches on all the way through August
00:00:17
and into September. But finally, nearly 2 months after Mary's death, they figure it out.
00:00:25
Mary died from an overdose of colchicine. I've never heard of that. >> Most people haven't. I hadn't before
00:00:34
this case. Colchicine is typically used to treat gout. But Mary didn't have gout. So,
00:00:40
there is no reason that she should have been taking it at all. Let alone the amount found in her system, which was
00:00:45
enough to kill her many, many times over. >> And I assume this isn't like an over-the-counter kind of thing.
00:00:52
>> No, no, no, no. You need a prescription. [music] And it's not like there's like a
00:00:55
street market for this thing either. >> for gout. >> Right. So, at first, poison control and
00:01:00
everyone is thinking that there could be basically like accidental ways this got
00:01:04
into her system. Both of which they need to identify fast because other people could be at risk. And so, the first
00:01:10
thought they have is, okay, she could have gotten it through contact with plants. [music]
00:01:14
Mary was this avid gardener and colchicine comes from a plant. So, maybe she ingested something that she [music]
00:01:20
grew. Okay, I don't know the ins and outs of this drug, but I feel like you'd probably have to ingest a lot of a plant
00:01:28
to die from it. And I I don't see that happening by accident. >> actually doesn't take that much. The
00:01:33
lethal dose is remarkably low, but there is a second, even scarier possibility. Mary was known to take a lot of
00:01:41
supplements, a lot of vitamins, and she even sold them out of her practice. So, they start thinking like, "Oh my god,
00:01:46
what if something that she was taking got contaminated during manufacturing?" At least if it was her garden, the
00:01:53
problem would be contained to her household. With this, I mean, they could be looking at a public health crisis.
00:01:59
So, they have her family go and collect and turn over everything they can find that she took regularly. And even though
00:02:06
it seems far-fetched, they do go even check her garden. But everything comes back clean.

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  • 60
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Episode Highlights

  • The Mystery of Colchicine
    Nearly two months after Mary's death, doctors discover she died from colchicine overdose.
    “I've never heard of that.”
    @ 00m 28s
    March 22, 2026
  • Public Health Concerns
    Investigators worry about potential contamination of supplements leading to a public health crisis.
    “At least if it was her garden, the problem would be contained to her household.”
    @ 01m 55s
    March 22, 2026

Episode Quotes

  • At least if it was her garden, the problem would be contained to her household.
    Investigators Couldn’t Identify the Poison at First... #maryyoder #truecrimestories #crimejunkies

Key Moments

  • Colchicine Discovery00:28
  • Public Health Crisis01:55

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