All-In Summit: Gene therapy and a new era of medicine with Dr. Nicole Paulk
- Sep 25, 2023
- 30:40
- Full Episode
This talk was recorded live at the All-In Summit 2023 at Royce Hall on UCLA's campus in Los Angeles.
(0:00) Besties welcome Dr. Nicole Paulk to All-In Summit ‘23! (0:59) An introduction to Gene Therapy (2:18) Three eras of modern medicine (4:49) Living medicines (6:35) Congenital blindness and other rare diseases (9:37) Gene therapy applications for broad use, including cancer (12:00) Immunosurveillance and immunotherapy (14:44) Brain cancer test (16:34) DEC2 mutation to reduce the need for sleep (17:45) Gene therapy for people living on Mars (18:40) Bestie Q&A: FDA hurdles and aging as a disease state (21:16) Biotech’s valley of death (23:52) Night vision and other human enhancements (26:32) Fundraising
Follow Nicole: https://twitter.com/Nicole_Paulk
Follow the besties: https://twitter.com/chamath https://linktr.ee/calacanis https://twitter.com/DavidSacks https://twitter.com/friedberg
Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast
Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg
Intro Video Credit: https://twitter.com/TheZachEffect
Relevant links: https://twitter.com/SirenBio https://sirenbiotechnology.com/
Brief Summary
Dr. Nicole Paul discusses gene therapy advancements, challenges, and future potential in medicine, including treating cancer and enhancing human capabilities.
Key points
- The Era of Living Medicines. Dr. Nicole Paul discusses the shift towards using living organisms in medicine, including viruses.
- Gene Therapy's Future. Dr. Paul predicts that everyone will receive viral gene therapy in their lifetime.
- Revolutionizing Cancer Treatment. Exploring the potential of using viruses to treat cancer through gene therapy.
- Gene Therapy Breakthroughs. Patients with a mutation in the dec2 gene only need four hours of sleep to feel rested.
- Future of Human Augmentation. Discussing the potential to enhance human capabilities for survival in harsh environments.
- Regulatory Hurdles in Gene Therapy. Exploring the significant regulatory challenges faced in bringing gene therapies to market.
Episode highlights
- The Era of Living MedicinesDr. Nicole Paul discusses the shift towards using living organisms in medicine, including viruses.“We're kind of quite literally living through one of the newest eras of modern medicine.”2:12Sep 25, 2023
- Gene Therapy's FutureDr. Paul predicts that everyone will receive viral gene therapy in their lifetime.“You are going to receive a viral gene therapy as medicine in your lifetime.”9:32Sep 25, 2023
- Revolutionizing Cancer TreatmentExploring the potential of using viruses to treat cancer through gene therapy.“Could you actually use a virus as a medicine that could be used to treat cancer?”10:16Sep 25, 2023
- Gene Therapy BreakthroughsPatients with a mutation in the dec2 gene only need four hours of sleep to feel rested.“These patients only need four hours of sleep a night to be completely rested.”17:04Sep 25, 2023
- Future of Human AugmentationDiscussing the potential to enhance human capabilities for survival in harsh environments.“We could absolutely engineer Humanity to withstand life in much more drastically harsh environments.”17:49Sep 25, 2023
- Regulatory Hurdles in Gene TherapyExploring the significant regulatory challenges faced in bringing gene therapies to market.“The regulatory hurdles are mostly going to be a regulatory timeline.”19:31Sep 25, 2023
- The Valley of DeathThe financial challenges biotech companies face in securing funding for clinical trials.“The biggest hurdle right now is access to Capital.”21:53Sep 25, 2023
- Augmenting Human PotentialImagining a future where we can enhance human abilities and experiences.“What other types of augmentations could we do for Humanity?”26:10Sep 25, 2023
