00:00:00
i'm absolutely convinced this will eradicate
and cure Alzheimer's really the data don't lie and I'm a data guy and that the future of
medicine and healthcare around the globe is
00:00:08
going to be dependent upon this dr nathan
Bryan is the biochemist whose cuttingedge research suggests how one crucial molecule
can impact our health brain function and
00:00:17
longevity that molecule is nitric oxide nitric
oxide is a ziggling molecule in the human body
00:00:22
which regulates things like blood flow and oxygen
delivery and the loss of nitric oxide production is the earliest event in the onset progression
of age- related chronic disease so things like
00:00:31
erectile dysfunction diabetes Alzheimer's high
blood pressure which is the number one driver of cardiovascular disease which is the number one
killer of men and women worldwide and 50% of the
00:00:39
patients that are treated with prescription
medication don't respond with better blood pressure because they aren't targeted toward
nitric oxide but most people have never heard
00:00:47
of this they don't know that if you can't walk
up a flight of steps or exercise moderately for 15 20 minutes then you're nitric oxide deficient
they don't know that most toothpaste and mouthwash
00:00:55
is killing the oral microbiome that's partly
responsible for production of nitric oxide but no one is interested in curing human disease
because medicine is a business and the epiphany
00:01:05
for me came because my dad had a car accident and
he developed these non-healing wounds and I saw the failure of the standard of care to treat dad's
wounds and so I just thought that there had to be
00:01:15
a better way and simply by giving nitric oxide
I've healed this wound within 6 months that's
00:01:20
crazy so how do I improve my nitric oxide levels
it's what you shouldn't be doing and we'll cover
00:01:25
those step by step number one you have to avoid
this has always blown my mind a little bit 53%
00:01:32
of you that listen to the show regularly haven't
yet subscribed to the show so could I ask you for a favor before we start if you like the show
and you like what we do here and you want to
00:01:39
support us the free simple way that you can do
just that is by hitting the subscribe button and my commitment to you is if you do that then
I'll do everything in my power me and my team
00:01:48
to make sure that this show is better for you
every single week we'll listen to your feedback we'll find the guests that you want me to speak to
and we'll continue to do what we do thank you so
00:01:56
much dr nathan Brian you have committed much of
your life to writing about and educating people
00:02:06
on a subject that I know absolutely nothing about
but from doing the research for today I'm pretty
00:02:12
shocked that I don't know more about this subject
so for those people who have just clicked to listen to this conversation can you tell them the
mission you're on and why it's so important yeah
00:02:23
well thanks so much for having this conversation
with me i think that illustrates the problem right someone as informed as you don't know anything or
never heard of nitric oxide so it's important for
00:02:31
us to just make a distinction between um like
nitric gas that people you know inhale and that
00:02:39
used if you played like uh some of those racing
car games you press a button and the car goes really fast if you That's nitrous nitrous nitrous
these are two separate things no very Yeah very
00:02:48
good point so this is not nitrous oxide nitrous
oxide is I mean a medicine is a dental anesthetic
00:02:55
right it's a gas it's called laughing gas that's
N2O that's the chemical formula what we're talking
00:03:00
about is nitric oxide or NO one nitrogen one
oxygen but yeah they sound very similar but
00:03:07
they're completely different this molecule is
is foundational for human health and longevity
00:03:12
so nitric oxide is a gas it's a naturally
produced molecule it's a signaling molecule in the human body and so it's it regulates
things like blood flow and oxygen delivery
00:03:21
and it mobilizes our own stem cells to help us
recover and repair and replace dysfunctional cells
00:03:27
that uh improves energy production inside the
cell and it regulates blood flow you know when
00:03:32
we begin to exercise if we want to recall memory
that's dependent upon adequate blood flow to the organs if we're you know it's intimately involved
in sexual activity and dilation of the sex organs
00:03:41
for sexual function so what we're finding is
that the older we get the less nitric oxide we
00:03:47
naturally produced and now today that's recognized
as the earliest event in the onset and progression
00:03:52
of age- related chronic disease so my mission
is to inform and educate the global population
00:04:00
on how important number one what nitric oxide
is how it's produced in the human body what
00:04:06
goes wrong in people that can't make it and then
perhaps most importantly how do we prevent that age related decline in nitric oxide production
so everybody can be empowered to take control of
00:04:17
their own health and prevent age related disease
and that's what the science tells us but as you
00:04:22
illustrated most people have never heard of this
i mean this graph which I'll put on the screen for anyone watching kind of illustrates what you're
talking about and quite notably this decline seems
00:04:30
to start when you're 30 years old which is how
old I am right now so well you know that's if you
00:04:37
look at population based studies at different age
groups we see about a 10 to 12% decline in what we
00:04:43
call endothelial function per decade so that means
so nitric oxide is a gas it's produced in the
00:04:49
endothelium so the endothelium is the single layer
of cells that line every blood vessel throughout the body so the function of these endothelial
cells is to regulate vascular tone and to regulate
00:05:01
you know solute exchange and extravisation or
transport of molecules across that endothelial
00:05:07
layer and so when your endothelial cells can no
longer make nitric oxide gas they no longer dilate
00:05:13
so the blood vessels become constricted you start
to get inflammation you get stiff arteries plaque
00:05:19
deposition and that's what starts cardiovascular
disease or atlascerosis which So someone that's
00:05:25
struggling with their nitric oxide levels at the
moment what kind of symptoms would they experience
00:05:33
well we know there's a hierarchy right so the
first sign and symptom of nitric oxide deficiency is usually erectile dysfunction and when you think
about this when we're stimulated or we're about to
00:05:44
have intimacy with our partner we have to dilate
the blood vessels so in erections in both men and
00:05:50
women are dependent upon dilation of the blood
vessels to get engorgment to get increase in
00:05:55
blood flow and that's what an erection is but if
those blood vessels can't make nitric oxide the
00:06:00
blood vessels don't dilate so there's no increase
in blood flow there's no engorgment and that's by
00:06:05
definition what we call in erectile dysfunction
and it's the same in men and women right whether it's the penis or the clitoris or the labia you
have to have an increase in blood flow and without
00:06:15
nitric oxide there's no increase in blood flow so
that's number one and we call that the canary in the coal mine because for years people thought
it was a lifestyle disorder right well erectile
00:06:25
dysfunction yeah but now it's recognized that it's
a symptom of loss of nitric oxide and really an
00:06:31
accelerated form of cardiovascular disease so
we have to focus on the vascular component of
00:06:37
erectile dysfunction what other diseases are
linked to nitric oxide deficiency so if if you
00:06:45
don't correct the ED then what you start to
see is an increase in blood pressure and when you think about this mechanistically so we have
you know a finite volume of blood that's pumping
00:06:53
throughout our body every day every second and
if you can make nitric oxide the blood vessels
00:06:58
are more dilated so now we're pumping that volume
through you know more dilated blood vessels but if
00:07:04
we lose the ability to produce nitric oxide now
you don't get the dilation now you have smaller blood vessels you're pumping that same volume of
blood through smaller pipes and simple physics
00:07:14
tells us that blood pressure goes up okay so
you're going to have cardiovascular challenges well you're going to have high blood pressure or
hypertension and at least in the US and I think
00:07:23
these these statistics probably are worldwide
but two out of three Americans have an unsafe elevation in blood pressure and 50% of the people
that are given prescription medications to treat
00:07:34
their blood pressure do not respond with better
blood pressure it's because most of the drugs out
00:07:40
there whether they're ACE inhibitors what's
called angotensin receptor blockers calcium channel antagonists the main classes of drugs
that treat high blood pressure aren't targeted
00:07:50
toward restoration of nitric oxide so that's
why we call that resistant hypertension they're
00:07:55
resistant to traditional therapies and the reason
they're resistant is because it's a nitric oxide problem and those drugs aren't designed to affect
nitric oxide production or improve it was there
00:08:05
a an aha moment in your career where you became
particularly interested in this subject because
00:08:11
you could have committed your life to studying any
facet of health or or science but for some reason
00:08:17
you chose nitric oxide as the thing that you chose
to focus on what was that eureka moment you know
00:08:24
for me it was I was a student at LSU School of
Medicine um this was the late 90s maybe early
00:08:30
2000s but a Nobel Prize had just been awarded for
the discovery of nitric oxide there were three US
00:08:35
scientists that were awarded the Nobel Prize
in physiology and medicine in 1998 and I was
00:08:40
very fortunate at the time i was a young student
probably a first year student and Lou Ignaro who had just won the Nobel Prize for the discovery
of nitric oxide came and spoke and gave a lecture
00:08:49
before the student body and I had a chance to
have a conversation with him afterwards and I was
00:08:54
fortunate to be invited to have dinner with him
that night and he made a very poignant statement to me he goes "If we if the scientific community
can figure out how to restore the production of
00:09:04
nitric oxide it'll change the world and it'll
change the landscape of medicine." because even then what is that 25 26 years ago that it was
recognized that a loss of nitric oxide production
00:09:16
is leading to the onset and development of many
poorly managed age- related chronic diseases so I
00:09:22
go that's a very profound statement from a guy
who just won the Nobel Prize but that was the first kind of eureka moment for me that stimulated
the interest but then my dad and I talk about it
00:09:32
in the book is a dad is 76 years old in 1984 he
had a car accident it left him paralyzed from the
00:09:39
midback down so the majority of my life even as a
kid I was treating dad's wounds decubitous ulcers
00:09:46
pressure ulcers on his feet on his butt and he
developed these non-healing wounds he was diabetic
00:09:51
he was parapolgic poor blood flow hypertension and
he developed a non-healing wound and no wound care
00:09:57
doc that I took him to could heal this wound
so I started making a topical nitric oxide and
00:10:03
I've healed this wound within a per four years of
non-healing i healed it within 6 months simply by
00:10:09
giving nitric oxide and getting blood flow to that
wound killing the infection in the wound and this
00:10:14
was in a 60something year old paraplegic diabetic
sedentary old man what you went through as a young
00:10:21
man to me appears to be such an important sort of
throughine with all the work that you do and chose
00:10:27
to do there is this overarching question which is
even like why did you go into medicine why did you want to help people where did that come from in
you and I feel like there's clues in that to some
00:10:37
degree based on what I I read about your family
your early upbringing the divorce of your parents
00:10:43
and then ultimately your dad getting in a car car
accident and being paralyzed is that an accurate
00:10:48
suspicion you know I certainly it directed kind
of my my life because I witnessed the failure of
00:10:55
the standard of care to treat dad with what I
thought should be pretty simple i mean we have
00:11:02
again the most advanced technology medical
technology best medical schools in the world
00:11:08
and yet we can't treat a wound we can't address
the hypertension we can't address the diabetes
00:11:15
medically and so I just thought that there had to
be a better way it's still with you now isn't it
00:11:25
yeah but I you know I see um you know dad when
think I'm having a bad day i just think look I'm
00:11:34
not in a wheelchair i got my health so no matter
how bad I think I got it it could always be worse
00:11:40
so I just wake up every day with a grateful
heart and you know some days are good some days
00:11:45
are bad but I always realize it could always be
better but it could be a hell of a lot worse so I don't complain and who are you what are all the
reference points what's the experience you've had
00:11:57
in your career that have filled up your sort of
buckets of knowledge that you bring forth today
00:12:02
like what what have you studied where have you
been i was in molecular and cellular physiology got a PhD in molecular and cellular physiology and
that was I was recruited by Fred Murad one of the
00:12:12
other guys who shared the Nobel Prize to join the
faculty at the University of Texas Health Science
00:12:17
Center in Houston which is the world's largest
medical center but it's part of the University of Texas system so I was recruited as a professor of
molecular medicine published probably well over a
00:12:28
hundred peer-reviewed scientific publications i've
edited several medical textbooks on the subject
00:12:34
i taught in medical school and then I resigned
from academia I guess several years ago uh
00:12:39
during COVID to focus on the next phase of my
career is taking this 25 years of science and
00:12:46
research and discovery and now bringing that
to the four for safe and effective product
00:12:51
technology drug therapies to eradicate a lot of
these poorly managed chronic diseases that you
00:12:57
know we're faced with today so let me get this
straight i'll repeat back to you what I think I understand about nitric oxide and you tell me if
it's accurate so this nitric oxide is a chemical
00:13:08
that is in all the blood cells of my body and
it allows my blood cells to basically expand
00:13:15
open up so blood can flow through there so if I
it dilates it dilates the smooth muscle so it's
00:13:20
not affecting the cells per se but it's dilating
the smooth muscle that surrounds the blood vessels
00:13:26
that leads to relaxation and dilation fine so my
blood cells would then expand your blood vessels and more blood would go through there but if
I'm deficient that mechanism doesn't work and
00:13:35
my blood cells wouldn't expand ultimately expand
through the relaxation of the muscles that's right
00:13:41
and therefore I would have higher blood pressure
which can lead to a series of downstream diseases
00:13:48
and consequences and so when we look at the graph
that I showed a second ago where we're seeing for
00:13:53
anyone that can't see this graph because you're
listening on audio we're seeing nitric oxide
00:13:59
levels in young people up to the age of roughly
around 20 are optimal and then from about 30 to
00:14:06
70 there's this tremendous sort of 80 90% drop
when I look at that graph though my question
00:14:11
becomes is that not just aging is that not just
normal is that not just inevitable well yeah
00:14:18
there are a lot of things that occur with aging
right we lose growth hormone with age we lose u you know many hormones uh nitric oxide is a
is a hormone that we we first discovered nitric
00:14:28
oxide as a hormone back in 2007 but to understand
aging you have to understand what leads to aging
00:14:35
so aging from my perspective is the inability to
repair and replace dysfunctional cells right every
00:14:41
day we wear ourselves out and we just got to and
if we can repair and replace dysfunctional cells then we combat or at least prolong the aging
process so what the science tells us in nitric
00:14:53
oxide is this that loss of nitric oxide production
is the earliest event in the onset progression of
00:14:59
age- related chronic disease so as that graph
implies it is part of the aging process but it
00:15:06
doesn't have to be right because today we know we
can shift that curve to the left or to the right so we can accelerate it and you see this today
with 18 20 year old kids that are have high blood
00:15:17
pressure they have diabetes they have erectile
dysfunction they have learning and and cognitive
00:15:23
uh impairment and those are all symptoms of nitric
oxide deficiency and to the contrary we if we see
00:15:29
50 60 70 year old patients that would fit on a
30 or 40 year old scale on that graph so this
00:15:37
this doesn't have to be the case we know how to
prevent this age- related decline in nitric oxide production you know I'm I'm the best example i'm
51 years old but I've got the vascular age of a
00:15:45
36 year old because I employ these principles
to prevent this age- related decline in nitric
00:15:51
oxide production and when you say you've got
the vascular age of a 36-y old how how does one measure that you look at the sort of vascular
health of your You can So there's there's several
00:16:00
objective measures of of biological age obviously
we can affect our chronological age right but
00:16:06
we can certainly affect our biological age so
what you can do there's databases now of what we call croted inima media thickness so they
take an ultrasound and look at your corroted
00:16:15
arteries and they can look at what's called smooth
muscle hyperlasia or the thickness of the inima
00:16:20
and compare it to a database of age matched
kind of really it's you're comparing against
00:16:27
your colleagues so that's one way another way is
looking at what's called flow mediated dilitation
00:16:33
or endothelial function and again through
database of hundreds of thousands or millions of
00:16:38
patients you can figure out where you fall on that
spectrum on endothelial function and then there's
00:16:44
um you know other mark markers looking at histone
modification of the DNA methylation profiles
00:16:50
there's a company or technology called glyen age
that looks at certain markers uh that can then
00:16:57
define a biological age for each individual so
by age 40 we have lost about 50% of our ability
00:17:04
to produce nitric oxide in our blood vessels and
we lose 10 to 12% of nitric oxide production per
00:17:12
decade this is all according to your book and
by age 70 to 80 nitric oxide levels in blood
00:17:17
vessels can be 75% lower than in young adults a
Japanese study found a 75% reduction in nitric
00:17:25
oxide production in people aged 70 to 80 compared
to 20 year olds interesting so in terms of chronic
00:17:36
disease that is downstream from me losing nitric
oxide level can you give me a bit of a menu of chronic disease that is associated with this
nitric oxide deficiency yep we've touched on them
00:17:49
so erectile dysfunction um 50% of the men over the
age of 40 self-report erectile dysfunction that's
00:17:57
in the US so think about that 50% self-report
i think the numbers are higher because most 40
00:18:04
year olds that I know are never going to admit
that they have erectile dysfunction so I think the numbers are even worse so that's one high
blood pressure again 50% of the patients that
00:18:13
are treated with prescription medication don't
respond with better blood pressure that's a huge problem because high blood pressure is the number
one driver of cardiovascular disease which is the
00:18:21
number one killer of men and women worldwide
number three metabolic disease and diabetes
00:18:27
we published in 2011 that nitric oxide production
is necessary for insulin signaling if the cell
00:18:33
can't make nitric oxide you develop insulin
resistance so diabetes a global pandemic nine out
00:18:39
of 10 Americans are metabolically unfit the other
thing is exercise intolerance if you if you try to
00:18:44
start an exercise regimen and you can't walk up
a flight of steps or exercise moderately for 15 20 30 minutes then you're nitric oxide deficient
and then the other one is uh obviously Alzheimer's
00:18:55
because Alzheimer's is a vascular disease it's
reduced blood flow to the uh to the brain we call
00:19:01
focal eskemia there's insulin resistance you know
Alzheimer's has been called diabetes type three so
00:19:07
you can't get it glucose into the cell that's the
primary energy source or substrate of the brain oxidative stress and immune dysfunction and then
you get um misfolded proteins and that shows up
00:19:18
as the tangles and the amaloid plaque that we see
in Alzheimer's patients so if we can restore and
00:19:23
nitric oxide corrects every single thing we know
about Alzheimer's it improves blood flow to the brain it improves glucose uptake so it overcomes
the metabolic aspect of Alzheimer's it reduces
00:19:35
inflammation in fact a number of my patents are
on a method of reducing inflammation it inhibits the oxidative stress we see in in Alzheimer's and
neurological disease and it prevents the immune
00:19:44
dysfunction and when you do that when you restore
blood flow and you get nutrients and oxygen in and you take out the metabolic waste products there's
no misfolding of protein so you don't get the
00:19:54
amaloid plaque you don't get the tangles so this
simple molecule nitric oxide gas I'm absolutely
00:20:01
convinced will eradicate and cure Alzheimer's
really because it it addresses every physiological
00:20:06
root cause of Alzheimer's if you can get it
administered therapeutically to patients early
00:20:13
enough or no I think that's a very key because the
success or failure of any clinical trial any drug
00:20:20
in any clinical trial is dependent upon the design
of the clinical trial and what patients at what
00:20:25
stage of disease that you enroll these patients
so what are the inclusion criteria and what are the exclusion criteria and there's a stage in
every disease whether it's heart disease kidney
00:20:37
disease Alzheimer's where you've reached a point
of no return there's really no medical therapy that's going to reverse that disease because
it's progressed to a state that's irreversible
00:20:46
so I think what we try to do is take take
patients early in the process what we call
00:20:52
vascular dementia mild cognitive impairment early
Alzheimer's because what I want to be able to demonstrate is two things number one can we stop
the progression of disease once it's started can
00:21:04
we stop the progression and then number two is we
want to enroll patients far enough along to where
00:21:11
we can show regression so can you move can you
move the needle back and so That's a very kind of
00:21:17
a specific and finite patient population when you
design a clinical study number one at the at the
00:21:24
absolute worst we want to stop progression at the
absolute best we want to show that we can regress disease and that's the goal of therapy is that you
understand the mechanism of disease to the extent
00:21:35
that you can treat it you can prevent it you can
reverse it and you can cure it is there something
00:21:41
you believe that the traditional world of medicine
and maybe the traditional media don't believe
00:21:49
yeah I believe in the truth and I come from a very
objective scientific background so everything that
00:21:55
we do is based on objective uh data i say this
because I was listening to your interview before
00:22:01
and there were several moments in the interview
where you'd reference that you'd say things like they don't they don't want you to know this or
they don't they won't tell you this no absolutely
00:22:11
because you know the we talk about epiphies and
eureka moments in science but for me one of the
00:22:19
kind of complete change in paradigm in the way
that I think was changed in when I was in academia
00:22:26
and teaching in medical school and doing research
in in an academic institution and you start to
00:22:31
think what we in the scientific community we un
we've cured every disease every disease known
00:22:38
to man we've cured it in rats and mice so then the
question is why isn't this translated into patient
00:22:45
care why can't we do this in humans number one in
in animal experiments we control their environment
00:22:50
we control their food we control their life
cycle we control everything about them you can't do that in everybody has a different diet
everybody has different drug therapy that they're
00:22:58
on or hygienic practices but then what I realized
was because when I was in academia we wanted to
00:23:06
create this consortium a center of excellence for
diseases because my thought process was you know
00:23:14
western medicine is siloed right if you have a
heart problem you go to a cardiologist you've got a GI problem you go to gastronurologist if you
got a neurological problem you go to a neurologist
00:23:23
or psychiatrist but none of these disciplines talk
to one another so if you go to that neurologist is
00:23:30
going to treat that condition much different than
the cardiologist would much different than the GI doc would but what if we're looking at the exact
same root cause and so my philosophy well let's
00:23:42
create a center of excellence and let's bring
everybody in the room let's bring the GI docs the the neurologists the cardiologists the geneticists
the pulmonary docs the kidney docs the renal docs
00:23:52
and let's let's understand this kind of wheel and
cog because everything occurs at the mitochondria
00:23:58
subcellular level and energy production and then
basically everything can can manifest from that
00:24:05
but what I quickly realized when you when you go
to for instance MD Anderson and trying to treat cancer no one is interested in curing cancer
no one is interested in curing human disease
00:24:18
because the epiphany for me came because medicine
is a business it's a for-profit business in fact
00:24:25
it's the largest business and economic model in
the world trillion dollar annualized market and
00:24:32
most of these drug companies who influence and pay
and support scientific journals JAMAMA New England
00:24:40
Journal of Medicine the major publications the
major journals and they're influencing regulation
00:24:46
and policy and FDA and so when you figure out
that there's undue influence by these for-profit
00:24:52
companies because the number one rule of business
as you know as an entrepreneur and a business guy
00:24:57
is acquire a customer and keep that customer as
long as you can call it lifetime value of that
00:25:03
customer and that's what medicine is they get you
they you acquire you as a customer they put you on
00:25:08
a drug that drug has side effects they have to put
you on another drug to mitigate the side effects of that drug now you got side effects from that
polyarm pharmacy they have to put you on another
00:25:17
drug to mitigate those side effects and now you
look up and people who are 50 to 60 years old and
00:25:24
older are on 10 12 18 different medications
that's the best financial model in the world
00:25:31
so it's a great financial model but it's at the
expense of our health and the health of everybody living on in the world and in the US you know we
have the sickest population in the world now for
00:25:41
the first time in the history of western medicine
have discussions between physician and patient how do we wean you off this drug that conversation
has never had before because it's always if this
00:25:52
doesn't work come back and I'll prescribe you
more drugs let's do the opposite you come back and let's understand the root of cause of disease
let's say okay well if we are addressing this you
00:26:01
don't need this medication and if you don't need
this medication you don't need this medication and now for the first time you start weaning patients
off of drugs and what happens you're now impeding
00:26:11
upon the market share of these multi-billion
dollar drug companies who make their living
00:26:19
buying influence regulating policy influencing
policy and the FDA is a stepping stone to a board
00:26:26
seat of big pharma every former FDA official in
the US for the past 20 or 30 years goes on to
00:26:33
become multi-million dollar salaried employee from
big pharma it has to stop despite spending nearly
00:26:39
20% of the United States GDP on healthcare the
US ranks last overall on health outcomes among
00:26:47
high income countries including having the highest
infant mortality rates and lowest life expectancy
00:26:55
it's like unbelievable no I mean that's that's
depressing i mean but those are the facts and
00:27:01
the you have to understand those those are
indisputable data right and so when people hear
00:27:08
that they go they this but when you look at kind
of the system and I don't blame doctors because
00:27:14
doctors are get into this field you know I was on
the admissions committee to UT medical school for a number of years so we interviewed a lot of these
young kids figure out what their motivation was
00:27:23
will they have a successful career in medicine
and almost everyone I mean there's always the exception but everyone gets into medicine
because they want to make make a difference
00:27:32
they're driven by curiosity and most of them want
to leave a lasting legacy and help people that's what drives uh entry into healthcare but when you
look at the system in which they're trained in it
00:27:44
prevents them it basically handcuffs them because
when you figure out the pay the economic model of
00:27:50
medicine once you make a diagnosis now you've
got a diagnosible disease to which you have a
00:27:56
finite number of responses right if you make this
diagnosis that's called an ICD10 code which is
00:28:02
reimburseable and that's how you get paid so once
you make a diagnosis you only have a finite list
00:28:08
of things you can do you can't ask that question
and go well what's really causing this and spend
00:28:13
you know 90 minutes with that patient because most
physicians have to see 60 70 80 patients a day to
00:28:20
pay the bills to cover their overhead so it's a
factory you come in you look at you've got a a
00:28:27
transcriber you make a diagnosis okay I can I'm
going to prescribe this medication come back in two weeks or six months and we'll see where you
are and then it's just it's a term it's a meal
00:28:36
but as you me the data don't lie right sickest
population highest infant mortality in the most
00:28:43
industrialized nation in the world and according
to the data Americans are spending about 13 years
00:28:48
of their life living with disease and that is
significantly higher than many other highincome
00:28:55
western countries so although life expectancy
you know might be 70 80 years old you're going to spend almost 15 years of that time living with
disease so your health span is um really probably
00:29:05
the more important thing to be focusing on not
your lifespan and so when we talk about nitric oxide I've heard you describe it as the molecule
of longevity for sure why why' you say that why do
00:29:16
you say that well again longevity is this emerging
field that's driven by how do we live longer how
00:29:23
do we increase our health span and longevity right
because I think we can all agree that nobody wants
00:29:28
to live to be 100 years old if we spend the last
25 of that years incapacitated in a diaper unable
00:29:34
to get out of bed right that's not living so when
I look at longevity I look at kind of what are the
00:29:41
hallmarks of longevity what defines longevity
right how do we live longer healthier life free
00:29:46
of disease and really there's three objective
measures there is a stem cells you know this
00:29:52
whole field of regenerative medicine is based
on mobilizing our own stem cells or deploying
00:29:58
u stem cells throughout the body to repair and
replace dysfunctional cells so these stem cells are cells that can basically act as like band-aids
repairs for any part of our body well we call them
00:30:07
pur potent stem cells so mean that and some of
these are bone marrow derived some of these are what we call stromal vascular fraction that you
get from the atapost tissue or the fat pur potent
00:30:16
would mean pur potent means they can that stem
cell can go and become a neuron that stem cell
00:30:21
can go to the heart and become a functional meioy
it can go and become a macrofase or an immune cell
00:30:28
white blood cell so pur potent means it can become
many things whatever it needs to be in some cases
00:30:34
the amount of stem cells present in our bone
marrow get smaller with age the number of cells
00:30:40
decrease with age but fortunately or unfortunately
the older we get the more fat we deposit and so
00:30:47
we have a number of stem cells in our fat so we
increase the number of stem cells in our fat so
00:30:52
the problem with aging and longevity is when we
lose the ability to mobilize our own stem cells
00:30:58
we can't we can't repair and replace dysfunctional
cells so we have these what we call zombie cells
00:31:03
or scinsesscent cells they're there but they
can't do their job they're dysfunctional and that's what leads to age number two it's telomeirs
and telomeirs are the ends of the chromosomes of
00:31:15
our DNA and so the they're the very end so it's
like the um the the tips of the sho strings
00:31:23
right that prevent the sho string from fraying
and those are like the telomeir so as long as you have a functional telomeir and it prevents
it from getting shorter then shorter telomeir
00:31:32
shorter lifespan longer telomeres longer lifespan
so when telomeirs get shorter it decreases our
00:31:38
lifespan and longevity and then the third one is
mitochondrial function every age- related chronic
00:31:44
disease you have a lower number of mitochondria
per cell and the mitochondria that are present
00:31:50
aren't functional so you get a what's called an
uncoupling of the electron transport chain inside the inner mitochondrial membrane and you can no
longer effectively produce cellular energy or ATP
00:32:02
so nitric oxide is the foundational longevity
longevity molecule because nitric oxide is the
00:32:07
signal in the body that tells our stem cells to
mobilize and differentiate without nitric oxide
00:32:13
you have less number of circulating stem cells
nitric oxide activates the enzyme toase which
00:32:19
prevents telomeir shortening without nitric oxide
you don't get activation of tomeorase telomeir
00:32:24
shorten and then nitric oxide is the signal in the
cell that tells the cell I need more mitochondria
00:32:32
and I need these mitochondria to be more efficient
generate more cellular energy with less oxygen so
00:32:39
when you when you restore nitric oxide you address
all three aspects of longevity and there's no
00:32:45
other molecule on the body that does that you know
Brian Johnson don't you yes what do you think of Brian Johnson you know I would never replicate
or try to um do what he does i don't think it's
00:32:57
the proper approach you know and I I don't I don't
mean to criticize people because this whole field
00:33:02
of biohacking you know you get people who have
no science background no medical background no
00:33:08
biochemical background and yet they're out there
influencing millions of people that follow them
00:33:15
and many times they're giving really bad advice
not intentionally it's because of ignorance they
00:33:21
just don't know they don't know the science they
don't know the medicine behind it so before you go and follow any influencer or biohacker number
one look at their credentials and if they don't
00:33:31
have any science background if they're you know
formal technologist or you know come from anything
00:33:37
besides science and medicine you really need to
do a little bit of deep dive and make sure that what they're giving you is scientifically valid
or recommending he seems to be a fan of um the
00:33:47
role of nitric oxide as it relates to longevity
though he seems to have said positive things about
00:33:52
um nitric oxide and its impact on improving
your cardiovascular health yeah i think as
00:33:58
we advance the science and we we do more to
communicate the complex science into you know
00:34:03
layman's terms where the the non-scientists
non-medical professionals can understand it and appreciate it i think more people are going to
pick up to that but there's also some well-known
00:34:12
biohackers with influences of you know millions
of people that still say that nitric oxide is a
00:34:18
toxin that inhibits mitochondrial respiration and
it should be avoided is there such thing as having
00:34:23
too much nitric oxide though because if people
hear this conversation today and they rush out and they I don't know overdo their nitric oxide by
doing a bunch of uh therapies yeah is that a risk
00:34:36
absolutely you know we know water is essential
right but we can drink too much water and kill ourselves you see it on the news you know a couple
times a year called hypotonic lis so yeah dose
00:34:46
dictates poison and so what we have to do is make
sure maintain the integrity of the field to make
00:34:52
sure that if there are nitric oxide products out
there that number one you don't overdo it and and
00:34:59
lead to you know health issues or kill a consumer
kill a patient that could kill the entire field
00:35:05
but we also understand that there's only two signs
of toxicity for nitric oxide so it's really pretty
00:35:11
straightforward number one if you take too much
nitric oxide you're going to get an unsafe drop in blood pressure because think about this if
you if you take nitric oxide or you're enhancing
00:35:20
nitric oxide production through whatever means
it's going to lead to systemic vasoddilation now
00:35:26
you've got that same volume of blood pumping
through much larger pipes and you're going to have a drop in blood pressure and if you lose
profusion pressure you're not going to be able to
00:35:35
peruse the brain because you got to pump against
gravity and you're going to get lightheaded and you'll pass out and if that's prolonged it leads
to es schemic end organ damage and organ failure
00:35:44
and it can be deadly so that's number one
and then number two is a condition called met hemoglobinia and that's a big word meaning
that your it oxidizes the iron of hemoglobin and
00:35:54
reduces your oxygen carrying capacity so you'll
become cyanotic you'll get blue around the lips your extremities will turn will turn um you
know white from lack of profusion or lack of
00:36:05
oxygen but you never see that I mean you really
never see clinical met hemoglobinia fortunately
00:36:11
your your blood pressure will drop to an unsafe
level long before you get any accumulation of met
00:36:16
hemoglobinia so on this point of longevity then
one of the points you mentioned there was telmir length and I've heard about telmir length because
I've heard about studies they've done in rats and
00:36:24
I think other rodents around telmir length so
it was discovered that indiv individuals with shorter telomeres had a death rate nearly twice
of those with longer telomeres and you're telling
00:36:37
me that there has been research done that
shows how nitric oxide can increase telmir
00:36:42
length absolutely so we we understand at the DNA
level at the nuclear level that nitric oxide is
00:36:51
is what's called a collocicalizes with estrogen
recep receptor to allow for the turning the the
00:36:58
cell to turn on transcription and translation of
the tomeorase enzyme so it's not only affecting
00:37:04
the genetic transcription of that protein but
it's also regulating the function of the enzyme
00:37:10
so without nitric oxide you have less telomeir
tomeorase enzyme and that tomeorase enzyme isn't
00:37:16
functional okay so nitric oxide has an impact on
the tomease tomeorase enzyme that's right tomeres
00:37:23
enzyme so what happens with each cellular division
those telomeirs can get shorter right but as long
00:37:28
as that tomeorase enzyme is active it prevents the
shortening of the very ends of the chromosome okay
00:37:34
and just for people that don't understand the um
with every replication as we age we're continually
00:37:40
replicating ourselves to restore and repair them
but in that replication process harm is occurred
00:37:46
sometimes yeah and different cell types have
different replication rates right so the the epithelium of the gut is highly regenerative right
it's it's a replicatable uh you replacing these
00:37:57
cells all the time because it's the outside
environment that you're having to continue to replace those cells neurons to the exact
opposite aren't regenerative by nature so we don't
00:38:07
typically make I mean we can it was once thought
that you can't regenerate neurons but today we know we can but yeah so it affects different organ
systems differently but the data are clear shorter
00:38:17
telomeres shorter lifespan the other thing that
um I wanted to talk to you about before we really get into the heart of how do I improve my nitric
oxide levels keep them at a healthy range while I
00:38:26
age is nitric oxide's relationship with the oral
microbiome i had a conversation on this podcast
00:38:33
not too long ago about the oral microbiome again
another subject I hadn't thought much about but is there a relationship there no doubt i mean
this is this is probably 20 year old science
00:38:43
um where we find that you know probably 20 years
ago the microbiome project was complete and what
00:38:51
that means is that the bacteria that live in and
on our body were completely mapped out and these
00:38:57
communities were identified in the gut started in
the gut the gastrointestinal tract and then you
00:39:02
know you can you can culture the the this the skin
flora there's bacteria that live on our skin there
00:39:08
are bacteria that live in our colon there are
bacteria in women that that that reside in the in
00:39:13
the vagina and so all of these different ecologies
of bacteria that live in and on the body are there
00:39:19
to do things to help the human host right we
call this symbiosis we're providing benefit to
00:39:25
the bacteria and the bacteria providing benefit
to the human host and so if you use antibiotics
00:39:33
or antiseptics to kill the bacteria that live
in and on our body you get human disease i mean
00:39:41
that's clear and the the best example is that
there's no physician in the world that would recommend you or I take an antibiotic every day
for the rest of our lives right do you agree with
00:39:50
that and why is that because the antibiotics are
killing the good bacteria they kill the infectious
00:39:56
pathogen bacteria but they also destroy
the entire microbiome and when you disrupt
00:40:01
the microbiome you get systemic disease you get
vascular disease you get Alzheimer's you get uh
00:40:07
leaky gut syndrome you get autoimmune disease you
get high blood pressure you get yeast infections
00:40:13
uh you get overgrowth of candida you get parasites
so the bacteria are really the police of the human
00:40:22
kind of surveillance right so the n we have 10
times more bacteria cells that make up the human
00:40:28
than we have human cells so we're 10 times more
bacteria than we are human and so if you destroy
00:40:35
that microbiome then it leads to systemic disease
we live in a culture where we're constantly trying
00:40:40
to kill bacteria right like especially post
pandemic we're using all kinds of hand washes and antiseptics and obviously the the big I
guess chemicals that we all typically use are
00:40:52
things like mouthwashes with uh which are again
trying to just clean out all the bacteria from our mouths what how would you caution someone
on using these things and even the like the
00:41:03
antibacterial Yeah it's bad news really we give
it to our children because we want our kids to be clean and not to have kids need to be dirty
you find and again you look at epidemological
00:41:13
data peop kids who grow up in the in a rural area
they're out in the environment they're rolling in
00:41:19
dirt they're they're got dirt on them and they
have um you know they're inoculated with a lot of bacterium those kids are the healthiest people
and and you look later in life they have lower
00:41:29
incidence of cardiovascular disease diabetes they
have better immune dysfunction less autoimmune disease so there's this whole hy hygienic
principle or hygienic hypothesis of disease
00:41:39
and I don't think it's a hypothesis anymore i
think it's proven out so for me I go back and I
00:41:45
go "What why are we doing this why are we using
fluoride rinses in dental offices why is there
00:41:51
fluoride in our toothpaste why is there fluoride
in the municipal water of 72% of municipalities in
00:41:57
the US when fluoride is a known antiseptic it's a
chemical toxicant it's a a thyroid toxic it kills
00:42:05
your thyroid and it's a neurological toxin." And
so when you go back and look at the history of
00:42:11
dentistry over a hundred years ago it was first
identified that oral bacteria can be found in
00:42:19
the plaque that killed someone from an acute
heart attack right people who died from sudden
00:42:24
cardiac death they'll take the thrombus or the
embleis that oluded that coronary artery and they
00:42:29
basically biops it and they find oral bacteria in
that plaque that caused the heart attack or stroke
00:42:37
so that told us there's an oral systemic
link there's bacterial transllocation of the pathogens that's why bleeding gums are a problem
because you've got bacteria in the mouth if you
00:42:46
got bleeding gums there's open blood vessels for
those bacteria to get into our blood supply now they become systemic cause inflammation plaque
rupture and heart attack and stroke so 100 years
00:42:57
ago with reason with good reason they go well
let's treat with an aneseptic we have to kill all
00:43:03
the bacteria in the mouth so if you have bleeding
gums there's no translloca transllocation of that
00:43:08
in the systemic circulation and we can prevent
heart attack or stroke that was a hundred years
00:43:14
ago and we've learned a lot in those hundred
years number one it wasn't recognized that we
00:43:19
have a microbiome on our body in our body so now
when I ask dentists all the time why do you use
00:43:26
floor and they go well it's been used for hundred
years and I go I don't care what the question is that's the worst answer you could provide just
because we're doing it because that's the way
00:43:33
we've always done it right so now we have
to understand how do we selectively kill the
00:43:38
pathogens while maintaining a healthy microbiome
and so this this field started probably in the
00:43:46
I mean some of the first papers were published
probably in the 90s showing that there were if you use mouthwash it destroyed the microbiome
and we saw an increase in blood pressure these
00:43:57
papers were published in the late 2000s we we
published on this probably in like 2008 2009
00:44:03
we created what's called an association so people
who had the healthiest and most diverse bacteria
00:44:08
in their mouth had the best blood pressure people
who had the least diverse oral microbiome and we
00:44:15
we could not culture any of these nitric oxide
producing bacteria appeared to have the highest blood pressure so that's what we call association
it's not causation but it's a nice association
00:44:27
so in 2019 we published a paper showing okay
let's now let's see if we do if we take normal
00:44:32
intensive patients young healthy people with good
nitric oxide good blood pressure and we just give
00:44:40
them mouthwash twice a day for seven days to kill
the entire oral microbiome and then we do tongue
00:44:46
scrapings to see if we're killing the bacteria
and we do blood pressure measurements and so we do that twice a day for seven days seven days
we bring them back in we measure their blood
00:44:55
pressure and then we stop for four days we say
okay don't talk don't take mouthwash for four
00:45:00
days then come back let's rememeasure your blood
pressure and let's do tongue scrapings and figure out what's happening to this these bacterial
communities and what we found was that if you
00:45:11
eradicate the bacteria within 7 days your blood
pressure goes up so if you use mouthwash within
00:45:18
seven days your blood pressure goes up i think it
occurs earlier but what we we looked at seven days
00:45:24
we only looked at day one at baseline seven days
and then four days after stopping the mouthwash
00:45:30
but in one 21-year-old kid his blood pressure went
up 26 millimeters of mercury which is put that in
00:45:36
context for me that's clinically hypertensive so
for every 1 millimeter increase in blood pressure that increases your risk of cardiovascular
disease by 1% so within 7 days we increased
00:45:47
this kid's risk of cardiovascular disease by 26%
simply by giving him mouthwash and explain to me
00:45:53
in layman's terms the mechanism there what's
going on well we're still trying to understand
00:46:01
mechanism again we're at the observational level
that's really indisputable because these bacteria there's what we call nitrate reducing bacteria
and humans do not have this enzyme so nitrate
00:46:11
is what's found in green leafy vegetables right
these these plants assimilate nitrogen in the soil in the form of nitrate we consume these
vegetables the nitrate is taken up in the gut
00:46:21
it's concentrated in our salivary glands and the
bacteria perform this metabolism of nitrate into
00:46:28
nitrite and nitric oxide and humans do not have
the the functional enzyme to do this so we're
00:46:34
100% dependent upon the bacteria so then now
because nitrate is inert in humans we we rely
00:46:41
on the bacteria to metabolize this molecule into a
usable form where we can make nitric oxide so when
00:46:48
you're killing the bacterium now the nitrate is
just being recirculated but you're you're you're
00:46:54
urinating because it's it's it's filtered across
the kidneys you poop it out and you sweat it out
00:47:00
so it's completely unchanged unless you have the
right bacteria and what we're finding is that that
00:47:07
oral production of nitride and nitric oxide
being produced in the acid environment of the stomach is somehow regulating resistance arteries
in dilation to normalize systemic blood pressure
00:47:20
so if I don't have a healthy oral microbiome then
you have an elevation in blood pressure and much
00:47:26
of the things you you're talking to me about
today in terms of dietary um changes won't have
00:47:32
any effect anyway because I need the bacteria
to convert it into nitric oxide as it relates
00:47:38
there are many benefits of of many nutrients
in foods particular plants that confer some
00:47:43
health benefits but when we focus specifically
on the benefits of nitric oxide from your diet
00:47:49
if you don't have the right oral bacteria you
get zero nitric oxide benefits from your diet
00:47:56
now you're going to get you know obviously
hopefully vitamin A vitamin C vitamin D from foods fiber other phytonutrients but in terms
of the blood pressure lowering effects of a for
00:48:06
instance a plant-based diet if you don't have the
right bacteria you get zero benefits of that have you seen a link between oral health and cancer
yes absolutely what have you seen people that
00:48:19
have dental infections root canals cavitations
from previous extraction sites have typically
00:48:26
cancer it sets the stage for cancer cell growth
and proliferation so and and I've you know I made
00:48:33
a controversial statement on a on a previous
podcast where I say number one I'm not an oncologist but people who have terminal metastatic
disease who aren't ready to die who are sent home
00:48:43
to die on hospice somehow find me and go can you
help me with this cancer and so the first thing
00:48:48
I always send them to is a dentist to see do you
have any active oral infections that may have led
00:48:55
to the development of the primary tumor in the
first place but obviously it's it's metastatic meaning that it's now everywhere it's it's it's
migrated outside that primary tumor but almost
00:49:05
always without fail they have an active oral
infection and it may be a symptomatic infection to where they know it and they have a toothache
or it may be an asymptomatic infection where they
00:49:14
don't even know they got a dental infection what
percentage of cancer patients that you see that you then refer to a dentist have an oral infection
people with primary tumors solid tumors so we
00:49:24
categorize these in bloodborne cancers something
like lymphoma leukemia multiple myoma which is a bloodborne cancer and those that have a solid
tumor a primary tumor that starts in the breast
00:49:35
the colon the prostate the lungs or the liver
without fail 100% of them have dental infections
00:49:43
but cause and effect is not possible to establish
here right because cause and effect no I don't think we're there yet i think probably as the
science advances and people start to look at
00:49:52
this because you may imagine if you have cancer
and you've been to the best cancer doctors in the
00:50:00
world and you've done surgery you've done chemo
you've done radiation you've gone through the standard of care and the cancer comes back
it's terminal it's metastatic and you tell
00:50:11
when I tell people well you need to go see a
dentist i mean many people laugh and they go "Have you what what in the hell did you just say
i've got cancer i don't have a dental problem."
00:50:21
And I go "Well perhaps you do." Because again
if you go back and always look at back what's
00:50:27
what's held true throughout ages and if you look
at ayurveetic medicine if you look at traditional Chinese medicine if you look at acupuncture you
know if you go back and you look if you don't
00:50:37
know what to look for you're never going to find
it if you know what to look for it's out there it's in the published literature but every tooth
in the body is connected to an organ system right
00:50:47
and so these are these are the meridians the
acupuncture meridians you know the analogy is they're circuit breakers so if you if you trip a
breaker in your home there's no electricity going
00:50:57
through that circuit so your oven doesn't work
your refrigerator doesn't work or your lights go out well the body is electric right and how do we
diagnose death no electrical activity right either
00:51:09
through an EKG or an EEG so the body is electric
and we're we're batteries and so if we get if that
00:51:16
red light comes on on our phone it says we have
a low battery everybody panics and goes and plugs it in and charges right and the human body is
the exact same we lose voltage over time and if
00:51:26
you've got a trip breaker from an infected tooth
there's no voltage there's no circuitry going to
00:51:32
that meridian that feeds individual organs so the
the best example is if you've got a root canal
00:51:38
and a 100% of root canal teeth are infected and
when you think and people go well that's not true
00:51:43
well think about what a root canal is you had a
toothache at some point because of an infection
00:51:50
so you go to the dentist and they pull the nerve
root out of that tooth so you don't feel the pain
00:51:56
anymore because there's no nerve root there and
they pull the blood supply out of that tooth now
00:52:01
you have no blood supply to that tooth and a tooth
is a crystallin structure it's a living organ with
00:52:06
no blood supply and no nerve root that's a dead
tissue so if you were to go in and we'd disconnect
00:52:12
your gallbladder for example and just cut the
blood supply to it the nerve supply to it within seven or 10 days you'd be dead from sepsis nobody
leaves dead tissue in the body and so then what
00:52:23
happens is when you leave the dentist what do they
do they put you on an oral antibiotic but they
00:52:28
must have forgotten they took out the blood supply
to that infected site so an oral antibiotic isn't
00:52:34
going to reach the sight of infection i mean to me
when you think when you sit back and think about this and go who the hell does this and why do they
do it well it's because what we've always done
00:52:44
so then what happens is these anorobic bacteria
they don't need oxygen they're sitting there in an anorobic low oxygen environment and they're
just eating away at your jawline they're just
00:52:53
like us do they they they metabolize they take
stuff in they poop waste out those waste products
00:52:58
uh accumulate it shuts down voltage and they eat
away at your jawline so then you've got osteom
00:53:04
necrosis osteomiitis and you don't even know it
and an x-ray will not show it and most dentists
00:53:09
unfortunately still use x-rays instead of a higher
resolution CT it's really interesting i was doing
00:53:15
some research in preparation for this conversation
around this subject of oral microbiome and cancer and the link there and one particular study that
was done um published in the New York Post but
00:53:23
done by a team of researchers found that this
was done at New York University as well so it
00:53:28
was published by the New York Post and done at
New York University they analyzed saliva samples of over 160,000 participants over 15 years are you
familiar with this study and they identified over
00:53:38
a dozen bacteria species linked to a high risk
of head and neck cancers with certain bacteria increasing the risk by 50% of getting a cancer
which is pretty shocking um literally I feel
00:53:48
like texting my assistant and asking us to book
a oral hygieneist and to change my mouthwash no
00:53:55
matter where I am in the world it seems like
everyone is drinking matcha and there's a good chance that that matcha you're drinking is made
by a company that I've invested more than seven
00:54:03
figures in who are a sponsor of this podcast
called Perfect Ted because they're the brand
00:54:08
used globally by cafes like Blank Street Coffee
and Joe in the Juice and many many more not only
00:54:14
can you get Perfect Ted Match in cafes but you
can now also make it at home much cheaper in
00:54:20
seconds using our flavored matcha powders that
I have here in front of me perfect Ted matcher is ceremonial grade and sourced from Japan it
is smooth it is naturally sweet not like those
00:54:30
bitter grassy matches that I tried before perfect
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Steven40 this one change has transformed how my
team and I move train and think about our bodies
00:55:04
when Dr daniel Lieberman came on the diio he
explained how modern shoes with their cushioning
00:55:10
and support are making our feet weaker and less
capable of doing what nature intended them to do we've lost the natural strength and mobility in
our feet and this is leading to issues like back
00:55:20
pain and knee pain i'd already purchased a pair
of Viva barefoot shoes so I showed them to Daniel
00:55:25
Lieberman and he told me that they were exactly
the type of shoe that would help me restore natural foot movement and rebuild my strength
but I think it was planttoicitis that I had where
00:55:33
suddenly my feet started hurting all the time
and after that I decided to start strengthening my own foot by using the Vivo barefoots and
research from Liverpool University has backed
00:55:41
this up they've shown that wearing Vivo barefoot
shoes for 6 months can increase foot strength by up to 60% visit vivarefoot.com/doac
and use code DOAC20 for 20% off that's a
00:55:55
vivobarefoot.com/dac use code DOAC20 a strong body
starts with strong feet if I've just listened to
00:56:05
everything you've just said there and I want
to improve my oral microbiome what should I be doing well I think the most important thing
we've learned is what you shouldn't be doing
00:56:14
right so it's not what should we do it's what
we shouldn't be doing number one we have to get rid of fluoride you know just this past weekend I
was speaking at a dental conference in Salt Lake
00:56:22
City and there were there people there from
the National Toxicology Program which in the US is the organization tasked with if there's any
kind of risk of exposure of environmental toxicant
00:56:35
they're charged with doing the toxicology studies
to see if there's an increased risk what is the risk and is there a safe level that is without
risk and what they report is that fluoride there's
00:56:47
no benefit of fluoride and it's all risk it lowers
IQ in kids by as much as seven points and it shuts
00:56:54
down your thyroid function and it's a neurotoxin
and as I mentioned before most toothpaste has
00:57:02
fluoride in it and if you read the back of your
toothpaste it will tell you at least in the US
00:57:07
I don't know about in other countries but it
says if you swallow this call poison control
00:57:12
because it's a poison they're putting poison in
toothpaste and then if you also pay attention it says only put a P-siz amount of toothpaste on
your toothbrush a P size but everybody that I know
00:57:25
fills the entire bristle of the toothpaste with
toothbrush with toothpaste so that's about 10 or
00:57:31
15 sometimes 20 P-size amounts of toothpaste and
a P-siz amount of toothpaste contains about half
00:57:38
a milligram of fluoride now if you're using 10
20 times more than that P size now you're exposed
00:57:45
to 5 milligrams 10 milligrams of fluoride and you
don't even have to swallow it this is a very small
00:57:50
molecule a molecular weight of 19 so it's absorbed
directly across the bugal mucosa the oral cavity
00:57:57
and it becomes systemic i'm not going to use it
anymore no you shouldn't what should I use instead
00:58:03
you have to use a non florinated toothpaste
and what about things like tongue scrapers
00:58:08
now tongue scrapers the data again that's time-
tested that's an ancient practice and even in
00:58:13
our study we found that people who do tongue
scraping have a more diverse oral microbiome and
00:58:19
they seem to have better oral health why is this
my girlfriend's been banging on to me she's always bloody right my girlfriend's been banging on to me
about tongue scraping for the last two years and
00:58:29
I've kind of just ignored her i've just kind of
Yeah babe sure and but when she's not in the bath bathroom I'm not using her tongue scraper because
it just looks strange i for me based on what I
00:58:39
knew about the oral microbiome and the microbiome
generally I'm like should I be scraping off all my bacteria well if you're going to plant a garden
do you plant a garden on untilled soil listen
00:58:50
I know nothing about gardening you're asking the
wrong guy so maybe yes I grow my own food okay so you have to till the soil right you got to break
up the soil so the seeds actually can be irrated
00:59:00
and you just break up that um that bofilm yeah you
take the back of the dorsal tongue i mean almost
00:59:06
to the point of the gag reflex and you just pull
that ideally copper tongue scraper forward and
00:59:12
you're going to see this goop coming in there but
it's it's like kind of like tilling the soil and
00:59:18
it's it's increasing the diversity of the the
dorsal part of the tongue the microbiome so my girlfriend was right in that regard yes but what
we found was in that one kid we saw the greatest
00:59:29
increase in blood pressure if you tongue scrape
and use antiseptic mouthwash that's the absolute
00:59:34
worst scenario interesting so if you just think
about this you're tongue scraping you're opening
00:59:41
up the pores and now you're using mouthwash
it's better to can easily penetrate deep in
00:59:46
the crypts of the tongue and more effectively kill
the bacteria so you want to tongue scrape and then use a toothbrush without fluoride toothpaste
absolutely and no mouth no no antiseptic mouth
00:59:56
rinse okay and what about going to dental
hygienists and things like that do you think
01:00:02
that's a advisable idea because once every quarter
or so um I'll go and see a dental hygienist just
01:00:08
to get everything sort of cleaned out no I think
that's a good proactive uh practice but you know
01:00:13
because you need to look at the um the health of
the gum tissue and the the gingal tissue and a
01:00:20
routine clean and scraping the the plaque off
the teeth and allow making sure you have good mineralization of the enamel of the tooth is
good but never let them do a fluoride rinse on
01:00:30
you okay is there anything else on this subject
of your microbiome and its relationship with nitric oxide that I need to be aware of before we
move on yeah we there's also data showing that if
01:00:39
you use mouthwash you lose the cardioprotective
benefits of exercise so think about this we know
01:00:46
that diet and exercise is the best medicine
and many people aspire to do that they they
01:00:53
go and they they try to eat good they avoid the
temptations of sugars and sweets they exercise
01:00:58
every day to try to increase their longevity and
cardiovascular health if you do that and you're
01:01:05
using mouthwash you no longer get the benefits
from exercise and we've already established you don't get the nitric oxide benefits from diet so
two out of three Americans wake up every morning
01:01:14
and use mouthwash and two out of three Americans
have an unsafe elevation in blood pressure what's
01:01:19
the mechanism there well because you're you're
killing the the the oral microbiome that's partly
01:01:24
responsible for production of nitric oxide without
nitric oxide you get constriction of blood vessels
01:01:29
and it leads to high blood pressure that's crazy
and is there a link between our hormone levels
01:01:36
things like my testosterone levels and the nitric
oxide yes so this is a two-way street so nitro So
01:01:42
in men testosterone activates nitric oxide
production okay in women estrogen activates
01:01:48
and stimulates nitric oxide production okay so
as long as we have optimal sex hormones and as
01:01:54
long as the enzyme in the lining of the blood
vessel can functionally produce nitric oxide that explains the cardio protective benefits of
hormone replacement therapy got you so taking
01:02:03
testosterone or um estrogen therapies helps to
increase my nitro oxide levels as long as the
01:02:10
enzyme is functional and coupled which means that
we have to we have to understand the enzyology
01:02:15
and the biochemistry of that reaction to where
when it's exposed to testosterone it the cell
01:02:21
can actually make nitric oxide in response
and there's a two-way relationship as well with exercise then because I've read in your book
that um exercise activates and stimulates nitric
01:02:31
oxide production but you also just told me that
if you want to get the great benefits of exercise you need nitric oxide in the first place because
else your blood cells are going to be very narrow
01:02:41
less oxygen traveling through you're going to do a
worse workout as well presumably well think about I mean there's other agonist too like vitamin D
i mean most Americans are deficient in vitamin D
01:02:51
uh people with low testosterone have erectile
dysfunction and why is that because they're not stimulating nitric oxide production and they're
not dilating the blood vessels so they develop
01:02:59
ED so all of this no matter what it is whether
it's related to vitamin D deficiency which is activating and stimulating of nitric oxide if it's
low hormones if it's poor diet sedentary lifestyle
01:03:10
all of that can be explained by insufficient
nitric oxide production when I think about the role that food plays in my nitric oxide production
what should I be eating to increase um my nitric
01:03:24
oxide levels or to keep them at a healthy level i
think it the same answer is for that too it's it's
01:03:31
not so much what we should be eating it's what
we should not be eating okay so we we'll we'll
01:03:36
cover those step by step number one you have
to avoid sugar and high glycemic index foods
01:03:43
because sugar is a toxin it's a poison and let's
think about what sugar is so when we eat sugar or
01:03:50
drink sugar beverages right whether it's sucrose
whether it's fructose whether it's high fructose
01:03:55
corn syrup the end result inside the human is we
see an increase in glucose so elevation in blood
01:04:02
sugar or blood glucose is diabetes right and now
there's continuous glucose monitors that you can
01:04:10
get anywhere and everybody does this so if you eat
something and it causes an increase in your blood
01:04:15
sugar blood glucose then you should avoid that
because glucose as the name implies is glue right
01:04:21
it's sticky and if we if you have a soda and you
spill it on your countertop you come back the next
01:04:26
day it's sticky right well that's what happens
inside the body that sugar sticks to everything it
01:04:32
sticks to proteins it sticks to enzymes it binds
to hemoglobin and sugar stuck to hemoglobin is
01:04:38
what we call hemoglobin A1C and what is that it's
a it's a marker of long-term glucose control if
01:04:46
you have hemoglobin A1C of greater than 5.7 you're
diabetic so it's not just hemoglobin it sticks to
01:04:52
it sticks to the enzyme that makes nitric oxide
in in biochemistry and enzyology enzymes have to
01:05:00
be able to undergo confirmational changes right
so it transfers electrons from one donor to an
01:05:06
acceptor and that's how biochemistry is is done
but if sugar is stuck to that enzyme it locks it
01:05:12
in some confirmation and it can't do its job for
it can't make nitric oxide so sugar is an absolute
01:05:18
poison and it kills many enzymes and binds to
everything and it lowers nitric oxide production
01:05:24
absolutely that's why diabetics have a 10 times
higher incidence of heart attack stroke all cause
01:05:30
mortality mortality that's why they develop neur
neurological or peripheral neuropathy that's why
01:05:36
they have non-healing wounds there's no nitric
oxide that's why they're developing diabetic retinopathy macular degeneration pancreatitis
i mean all of that can be traced back to a lack
01:05:47
of nitric oxide production because the sugar
stuck to the enzyme the sugar destroys the oral
01:05:53
microbiome and completely changes the the ecology
of the bacteria and completely shuts down nitric
01:05:58
oxide production just a bit of a tangent there
you mentioned that's why they have open wounds
01:06:04
that don't Yeah diabetic ulcers okay so nitric
oxide's playing a a role a healing role in wounds
01:06:11
and scars absolutely so I've got this scar on my
head i was playing football the other day someone ran into the back of my head and uh they they like
they they passed out and um got taken away by an
01:06:20
ambulance but I was just left with this big like
scar on the back of my head which I've had like
01:06:25
glue stitched so I'm wondering I'm like if I apply
the nitric oxide serum it'll stimulate blood flow
01:06:31
to that it'll improve cellular turnover and and
heal that wound and basically remediate the scar
01:06:36
and how do I do that is it Yeah so you take one
pump from each side so one pump from this side and turn it around one pump from the other yeah
and now if you apply that and mix it together as
01:06:46
soon as you mix it together it starts to generate
nitric oxide gas so then that gas will diffuse into that tissue it's going to increase blood
flow and it's going to mobilize stem cells and
01:06:57
it's going to improve cellular turnover and
completely remodel that and heal that and if it were an infection in there it would kill the
the the infectious bacteria okay well we shall we
01:07:08
shall see if that worked so back on this point of
food then so sugar's bad sugar's bad yeah you got
01:07:14
to eliminate sugar and I think the benefits of it
like a straight ketogenic diet or a straight you know vegan vegetarian diet is just the elimination
of sugar and carbs right but I think to answer
01:07:25
your question what should we be eating i think
you've got to eat a balanced diet in moderation you know Americans are overfed all you got to do
is walk around and see the the epidemic of obesity
01:07:36
good high quality protein good quality fats and
little or no carbs and it's really that simple and
01:07:44
why did you write a book about beetroots beets
yeah the beets hit the uh really the airwaves
01:07:51
back in 2012 in the London Olympic Games mhm uh
there was a lot of data coming out at the time
01:07:56
of the benefits of beetroot juice on enhancing
athletic performance and there was a a benefit
01:08:02
of the nitric oxide being produced that could
explain the improvement in athletic performance
01:08:08
the problem is these athletes were drinking liters
and liters of beetroot juice and causing a lot of gastric discomfort causing diarrhea their urine
and their feces would turn red and a lot of people
01:08:18
interpreted misinterpreted that as gastric bleeds
or urinary bleeds and then when I started looking
01:08:24
at the products on the market most of the bead
products the desiccated bead powders provided
01:08:29
zero nitric oxide benefit they didn't contain any
nitrate no nitrite they were just we called them
01:08:36
dead beats they're they're a dead beat product
and so I thought if people if consumers are out
01:08:42
there looking for beets because they've been
shown to enhance their performance but that
01:08:49
enhancement in performance was dependent upon the
beets ability to improve nitric oxide production in the body then the non-scientist out there
wouldn't know what to look for right they're
01:08:59
buying products that aren't providing any benefit
to them and so years ago we would do randomized
01:09:04
placeboc controlled clinical trials and we would
take some of these commercial bead products that you can go to your local nutrition store or
pharmacy buy off the shelf and we would use
01:09:14
those as placeos in our clinical trials because
it's the perfect placebo so what I tried to do in
01:09:20
that book is educate okay what is it about beets
that are so important what's the mechanism and
01:09:25
what is necessary in those beets that can improve
nitric oxide production so again everything I do
01:09:32
is intended to educate and inform the consumer
so that they know how to make informed educated
01:09:39
choices on the products they're taking or the
foods they're eating or their oral hygienic practices trying to find the page in your book
but there was a page in your book where you
01:09:51
describe beetroot as the most un as the most
underappreciated food in the history of eating
01:10:00
yeah that may be in the beat the odds um I
thought it was in this book but if you if you go back to historical times and you look at the
the hieroglyphics on caves of the ancient cavemen
01:10:11
you know people thought they were drinking wine
because they would have these red stuff in this before battle but what these ancient Egyptians
were doing was they were drinking beet juice
01:10:22
to improve their performance before they went
into battle so that they were ready they were energized they improved their circulation
so that's the historical study on beets and
01:10:32
obviously these were beets grown at a time when
there were no herbicides pesticides and the soil
01:10:37
was probably fertile so these beets were full of
nutrients probably full of nitrate that provided the the benefits of that but unfortunately today
the beets that are grown at least in America um
01:10:48
really are nutrient depleted just like most of the
food so would you recommend people eat beetroots
01:10:55
no because as would again through our survey
that we published in 2015 we realized that you really can't eat enough beets to get enough
nitrate to improve your performance and the other
01:11:04
caveat is that if you're using mouthwash you've
got fluoride in your toothpaste or fluoride in your drinking water that you're mixing the beet
powder in you're not going to get a nitric oxide
01:11:11
benefit from it there's a graph in front of me
here which I printed off which shows the rise in antacid medications oh yeah from 2004 to so a
20-year period we're seeing um what is that almost
01:11:25
a quadrupling of the use of ant acids and this is
globally or is this in the US that's worldwide I
01:11:32
believe yeah worldwide now this is the problem I
mean these these ant acids what is an antacid so
01:11:39
it's a medication that's given orally to suppress
stomach acid production and as a biochemist
01:11:47
and physiologist I can't think of nothing more
damaging than to inhibit stomach acid production
01:11:53
because stomach acid is required to break down
proteins into amino acids whether it's you're
01:11:59
eating animal protein or or plant-based protein
it's required for nutrient absorption you need
01:12:04
stomach acid to absorb B vitamins you need stomach
acid to absorb selenium chromium iodine magnesium
01:12:12
iron i mean most nutrients micronutrients
are absorbed in the lumen of the stomach
01:12:18
and if the stomach cannot is not making stomach
acid then these nutrients are not absorbed and
01:12:23
most Americans 75% of Americans are deficient in
magnesium 95% of Americans are deficient in iodine
01:12:33
i mean it's a huge problem these are the brands
like Gavascon no these are like the the prylok the
01:12:39
previsids the nexium the prescription medications
are omerazol pentopresol these you today in in the
01:12:46
US I think it's probably worldwide you don't even
need a prescription for these from your physician you can go to your local drugstore and you can buy
these what we call proton pump inhibitors or PPIs
01:12:57
what about Tums over the killer Tums so there's
a difference in so Tums and things like baking
01:13:04
soda are a buffer right sodium bicarb or calcium
carbonate and it's a buffer right so if you if you
01:13:12
have an acute bout of hyper secretion of acid you
can take a Tums or some buffer some base alkaline
01:13:20
substance to neutralize the acid neutralizing
acid is completely different than inhibiting its
01:13:26
natural production in the polyoric cells of the
stomach so what is the difference between some have you heard of gavascon before yes yeah what's
the difference between like a gavon well there's
01:13:35
there's certain classes of ant acids there's what
we call H2 blockers there's proton pump inhibitors
01:13:41
and then there's the natural buffers that are
just kind of neutralizing the acid environment in the stomach gavascon I'm trying to think um what
class that falls under i don't think it's widely
01:13:51
used here in the US i mean the main drugs used
here are Prolysk Nexium Previsid those are the overthec counter and then the main prescription
medications are the omeraol and the pentoresol
01:14:01
gabaskcon is a commonly used antacid brand and
the active ingredients are aluminium hydroxide and
01:14:09
magnesium carbonate oh so Gavascon so number one
it's got aluminum in it which you should should
01:14:14
absolutely be avoided uh but yeah that just
it looks like a buffer it's got an hydroxide aluminum hydroxide which is a strong base so it's
neutralizing the stomach acid production but it's
01:14:25
it's a neutralizing agent but anything that
contains aluminum you should absolutely avoid um my as I mentioned her a few times today but
my girlfriend's a breath practitioner she runs
01:14:34
a business called barley breathwork.com hashtag
ad um and one of the things she's talked to me a
01:14:40
lot about is mouth breathing and I know there's
a a relationship between nitric oxide and how we
01:14:46
choose to breathe whether it's through our nose
or through our mouths can you explain to me that that link you know when we talk about the enzyme
that's found in the lining of the blood vessels
01:14:56
we started this segment that same enzyme is
found in our epithelial cells in our upper airways in our sinuses so just like exercise can
activate nitric oxide production in the lining of
01:15:07
the blood vessels deep breathing nasal breathing
activates that enzyme in the epithelial cells of
01:15:13
our sinuses and so when we do nasal breathing it's
activating the enzyme to make nitric oxide and now
01:15:19
we're delivering that nitric oxide gas into the
the bronchules the lower airway it's dilating
01:15:25
those bronchioles moreover it's dilating the
pulmonary arteries so now we're improving oxygen
01:15:31
uptake oxygen delivery and that's why nasal
breathing and deep breathing has been shown to lower blood pressure this is a pretty crazy
graph I took from Google as well which shows
01:15:39
just how interested people are now getting in the
subject of mouth breathing oh yeah again going over the past uh 20 years yeah i know I think
there's a lot of people I mean obviously your
01:15:50
girlfriend there's a Patrick Mchuan Mchuan in um
Oh yeah the UK came into Dragon's Den I and I uh
01:15:56
did a made a minoffer in Dragon's Den no I think
that the the the benefits of that are pretty well
01:16:02
and mechanistically we understand the benefits
of it so the the mouth breathers are not only bypassing this natural nitric oxide production
pathway but when you mouth breathe it completely
01:16:13
changes the microbiome and you so you're not
only bypassing the nitric oxide producing in
01:16:19
the upper airway but you're inhibiting nitric
oxide production in the mouth from the microbiome
01:16:24
because you're fully oxygenating the mouth it's
changing the pH of the saliva and completely
01:16:29
changes the microbiome and completely shuts down
nitric oxide production interesting interesting
01:16:37
so so you have to I mean I'm a big fan of of
mouth taping but for me I know and I watch my
01:16:44
kids but sometimes there's anatomical issues where
there's obstructive airways and airway obstruction
01:16:50
that has to be corrected by dental appliances
or some sometimes surgery but the worst thing
01:16:56
you can do is tape your mouth and your airway be
constricted and you know suffocate so before you
01:17:02
do mouth taping you need to get um you know some
some imaging done from your dentist to make sure that your airway is is open to where if you forced
to breathe through your nose you can actually have
01:17:11
oxygen exchange and is there anything else that I
could and should be doing to increase and improve my nitric oxide levels that we haven't talked
about yet humming you know there are certain
01:17:20
frequencies um we've done this and looking at
nitric oxide coming out of the exhaled breath
01:17:25
when you're humming so certain frequencies can
activate this enzyme and it's dependent upon the
01:17:32
volume of the nasal sinuses so there's not one
frequency that would work in every single person because the volume of your airways and and oral
cavity and sinuses was probably much different
01:17:41
than mine give me an example show me well if you
just you know like ohms like you do in meditation
01:17:47
or just simple humming you could actually so if
I had my ozone or gasphase analyzer here I could
01:17:53
hum and I could detect nitric oxide coming out
of my exhaled breath because of the frequency
01:18:00
of the because of the frequency and activating
the the nitric oxide synthes enzyme but if you
01:18:06
take older patients and we've demonstrated this
it's published years ago and other other groups have demonstrated this older patients that their
enzyme isn't making nitric oxide whether they do
01:18:17
nasal breathing or whether they do humming there's
no nitric oxide coming out so again this is an activator and a stimulator but it's dependent upon
the function of the enzyme that makes nitric oxide
01:18:27
if your enzyme is broken humming nasal breathing
exercise isn't going to produce any nitric oxide
01:18:32
is there anything else that I should be aware of
if I'm trying to improve my nitric oxide levels i think it's it's it's doing the things that disrupt
it get rid of fluoride get rid of mouthwash stop
01:18:41
using ant acids stop eating sugar anything that
leads to an elevation in blood sugar a balanced
01:18:47
diet in moderation moderate physical exercise 20
to 30 minutes of sunlight a day sunlight sunlight
01:18:53
there are certain at both both ends of the
visible spectrum both or the UV spectrum and the
01:19:00
um full spectrum infrared so those frequencies and
vibrations again stimulate nitric oxide release
01:19:08
so the UV has enough energy to where it'll it'll
knock nitric oxide bound to a cysteine and protein
01:19:14
and then the UV spectrum will release nitric oxide
bound to metals so you mean go out in the sunshine
01:19:20
but also those red light beds and stuff yeah the
red light I have an inf I have a red light bed i have an infrared sauna that uses red lights in
it and it's I use it every day for nitric oxide
01:19:30
production yeah and there's there's other benefits
of light you know it can stimulate mitochondrial
01:19:36
biogenesis it improves energy production it can
lower blood pressure but yeah lots of benefits of light therapy and yet we're programmed to
not go outside if we go outside put on SPF 60
01:19:47
and intoxicate oursel with these cancer-causing
chemicals and sunscreen I mean makes no sense what
01:19:54
is the most important thing we haven't talked
about that we should have talked about today Dr nathan you know I think the future of Well I I
don't think I'm I'm I know you know there's three
01:20:04
levels of conviction you think you believe and
you know i'm at the point of knowing now that the future of medicine and health care around the
globe is going to be dependent upon nitric oxide
01:20:14
product technology because I think we can inform
and instruct people to stop doing things or start
01:20:20
doing things but the most difficult thing to do
is to change people's habits and to get people
01:20:27
out of their comfort zone and stop drinking
sugar soda waters eliminate sugar to the best
01:20:34
extent possible get 20 30 minutes of exercise a
day and completely change your diet compliance is
01:20:40
an issue people don't do that they we're we're
programmed to want to take a pill to overcome everything and there's that pill nitric oxide is
very important but it's not a silver bullet it's
01:20:49
not going to overcome all your bad habits but what
it is going to do it's going to correct a lot of the things that your bad habits are leading to a
deficiency of well it's a good thing we have um
01:20:59
a lot of people that are devoted to finding new
solutions to old problems and you're certainly
01:21:05
one of those people and it's super fascinating
because as you say as I said at the start of this conversation I had no idea about any of this
stuff beforehand i had no idea I'd not really even
01:21:13
heard that the word nitric oxide and maybe I'd
heard it in passing but um maybe I was confusing
01:21:18
it with that NOS gas that people talk about and
that some people inhale and maybe because I hadn't
01:21:24
added context and story and understanding to it
maybe I'd heard it in passing but didn't know what it was or meant so it's really wonderful that
you're leading the charge in educating the world
01:21:33
on nitric oxide because it's clearly a a really
really important molecule in the the broader picture of our health and the more we understand
it the more we ask questions about it and have
01:21:42
curiosity about it the higher the probability
that we're going to be able to build some of these therapies that prevent us from ending up
in a state as we've seen in some of these graphs
01:21:49
where we're deficient in nitric oxide and then
have to deal with the downstream consequences of that so thank you for all the work that you're
doing it's really really important i'm going to
01:21:57
ask you one final question which is the question
left by our previous guest Kim they don't know who
01:22:03
they're leaving it for and they write it into this
diary so the question that's been left for you is are you happily or unhappily mated and why
happily or unhappily mated you know one of my
01:22:20
biggest challenges in life is maintaining
balance right because I've been so focused on you know discovery and research and leaving a
lasting legacy and and making innovations and and
01:22:33
doing doing things in the scientific and medical
community that many people said couldn't be done
01:22:39
and so my the problem is is there's always
a deficiency you know I've got young kids i
01:22:45
spend a lot of a lot of time away and you know
that's you know I'm happily mated but there's
01:22:51
deficiencies right because again my challenge is
always maintaining balance work home life kind
01:22:59
of maintaining you know my spiritual my you
know it's it's it's it's mental it's physical
01:23:04
and it's spiritual health I'm trying to do better
at that now but you know you can't there's always
01:23:10
sacrifice right and we just have to pick pick
our sacrifices and you know so I've got to I've
01:23:16
got to choose to do better yeah everything has
a trade-off as many of my guests have told me
01:23:22
thank you so much for the work that you do
where do people if people want to find out more about you if they want to read more they
should certainly get this book which you've
01:23:28
just released called The Secret of Nitric Oxide
um I'll link it below for anyone that wants to
01:23:34
have a read of this book i highly recommend you
do because it gives an even more comprehensive understanding of everything we've talked about
today and it's incredibly accessible which is
01:23:41
always critically important to me um but if they
want to find out more if they want to understand the products that you you sell and anything else
where do they go well I I mean obviously I'm I'm
01:23:50
here to educate and informal nitric oxide you
know this latest book The Secret of Nitric oxide bringing the science to life really
chronicles both my kind of journey through
01:24:00
science and medicine as you revealed kind of my
early years and kind of what motivated me to go into space but I think more importantly it tells
the story of nitric oxide what it is what led to
01:24:10
a Nobel Prize for its discovery what you can do
to prevent the loss of this molecule so you can
01:24:17
go to nathan'sbook.com or you can get it anywhere
books are sold Amazon Barnes & Noble i've got a YouTube channel Dr nathan S brian nitric oxide
where we provide education information latest
01:24:29
scientific information on nitric oxide you can
find me on social media Instagram Dr nathan S
01:24:35
brian and then for those who want to follow our
product journey and you know bringing forth safe
01:24:40
and effective product technology that's none.com
so it's the letter N the number one letter number
01:24:46
one.com but you know we make products that release
nitric oxide dr nathan Brian thank you so much for
01:24:52
your time today being so incredibly generous
but thank you so much for educating the world in such an articulate and accessible way on a
subject that few of us knew very little about
01:25:01
it's incredibly important work and it's gonna
it's inspired me to think again about my diet and about the decisions I make the habits I have
about exercise about sunlight exposure about my
01:25:09
oral microbiome all of these things so thank you
so much for that it's a real gift and I appreciate you taking the time today well thank you so much
it's pleasure being with you this has always blown
01:25:18
my mind a little bit 53% of you that listen to
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01:25:31
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01:25:39
you want me to speak to and we'll continue
to do what we do thank you so much [Music]
01:25:56
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