Neuroscientist: “Alzheimer’s Is Optional” (95% of Cases Are Preventable)

The Diary Of A CEO

  • Feb 5, 2026
  • 2:05:14
  • Full Episode

Alzheimer’s expert LOUISA NICOLA explains early Alzheimer’s risk, why creatine fuels brain energy and memory, deep sleep hacks, and why sitting is a silent killer!

Louisa Nicola is a leading neurophysiologist and human performance coach who studies the brain and nervous system. She is the founder of Neuro Athletics, a consulting firm that provides scientific strategies for cognitive performance, and is also currently finishing her PhD at the University of Washington.

She explains: ▪️Why 70% of Alzheimer's patients are women ▪️The "leaky brain" warning signs you are ignoring ▪️Why menopause triggers a 30% drop in brain energy ▪️How 20 minutes of Zone 5 training reverses heart aging ▪️Why your "willpower muscle" shrinks without hard challenges

00:00 Intro 02:28 Why I’m on a Mission to Prevent Alzheimer’s for Millions 02:55 The Real Reason Alzheimer’s Is More Preventable Than You Think 04:31 How Lifestyle Choices Quietly Lead to Dementia 08:40 Why Some Older Adults Stay Mentally Sharp — and Others Don’t 12:32 How Short-Form Content Might Be Damaging Your Brain 13:44 The Surprising Way Exercise Boosts Cognitive Function 16:28 What Strong Legs Reveal About Your Brain’s Health 17:20 How Resistance Training Powers Up Your Brain 21:05 Can Exercise Actually Help Prevent Cancer? 22:55 The One Exercise Every Brain Needs 25:39 How Aerobic Training Could Help Prevent Alzheimer’s 28:44 The Brain-Heart Connection: Reducing Cardiovascular Disease 32:12 Why VO2 Max Might Be the #1 Predictor of How Long You’ll Live 34:42 The Best Exercises for Long-Term Brain Health and Longevity 41:42 What to Do Immediately After an Alzheimer’s Diagnosis 45:02 Why the Ketogenic Diet May Be Crucial for Women in Perimenopause 50:09 What You Need to Know About Hormone Replacement Therapy 52:28 The Truth About Finding the Best HRT Option 01:00:21 Ads 01:01:53 The Hidden Link Between Sleep Deprivation and Alzheimer’s 01:03:39 Why You Need to Fix Your Sleep Routine Now 01:06:58 Can Ashwagandha and Rhodiola Really Help with Stress? 01:09:59 The Most Powerful Supplement for Brain Health 01:14:01 How Vitamin D Plays a Role in Living Longer 01:15:00 The Most Affordable Way to Boost Your Brain and Body 01:34:31 Ads 01:36:24 Why Doing Hard Things Is Literally Growing Your Brain 01:43:25 What Brain Rot and Chatbots Are Doing to Us 01:49:00 The Truth Every Woman Deserves to Hear 01:57:36 Do You Ever Wish You Weren’t So Obsessed With Your Mission?

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Independent research: https://stevenbartlett.com/wp-content/uploads/2026/02/Copy-of-DOAC-Louisa-Nicola-Independent-Research-further-reading.pdf

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Brief Summary

Louisa discusses Alzheimer’s prevention through lifestyle changes, exercise, and the benefits of creatine for brain health.

Key points

  • Alzheimer's Disease Statistics. 60 million people worldwide have Alzheimer's, and that number is projected to triple by 2050.
  • Myioines and Brain Health. Myioines are signaling molecules that help grow new neurons in the brain.
  • The Impact of Sedentary Lifestyle. Sitting for more than 10 hours a day increases cardiovascular disease risk, even with exercise.
  • Impact of Exercise on Heart Health. A variety of exercises can profoundly impact heart health, reversing age-related decline.
  • The Role of Estrogen in Brain Health. Estrogen plays a crucial role in maintaining brain health and preventing Alzheimer’s.
  • Sleep and Alzheimer's Prevention. Deep sleep activates the brain's cleaning system, crucial for preventing Alzheimer's.

Episode highlights

Tension

65/ 100Some tension

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