Science Corner with David Friedberg: GLP-1 Study Shows Encouraging Results

the one I wanted to do is that new macro study on gp1s which I think is super interesting oh tell us do you guys remember I talked a while ago about how they were able to mine VA data so the VA right they they take care of veterans and they have all the medical records and on an anonymized basis they can make that data available to researchers and so if you guys remember this this is how they identified that the Epstein bar virus or the virus that causes mono as being statistically certain to be the trigger for multiple sclerosis in the cohort of hundreds of thousands of patients that were in this this data set no one got Ms that didn't get Epstein bar

virus if you did not get Epstein bar virus you did not get Ms I don't know if you guys remember I did the science Corner a while ago anyway so the data set that you can mine at the VA is incredible so they pulled all the data from everyone that's been on the glp1 agonists and they identified all of the health effects across multiple indications the statistical difference between the cohorts okay so this research team out of St Louis pulled all the data from the VA database and basically they looked at you know 1.2 million people with diabetes that didn't take anything compared to 215,000 that took the glp1 receptor agonists and another 600,000 people that took other

drugs for diabetes so basically this cohort segmentation allows them to isolate the effect of the glp1 drugs um and as you can see here this shows across hundreds of thousands of patients the effect of the glp1 on a hazard ratio which means like How likely are you to have the following health condition versus the population that's not taking the glp ones and then uh on the right if you scroll to the right Nick are the increase in risk and on the left are the things that go down so the increase the only thing that increased is like you know 8% or 10% increase in nausea and vomiting y confirm uh muscular skeletal

complications grd which is you know gastric reflux from sleep indigestion yeah and sleep disturbance to indigestion so it's all abdominal stuff now if you go over here to the benefit side so the benefit side is what conditions did you see a decrease in so you have a decrease in shock a decrease in uh he hepatic failure so liver failure respiratory failure cardiac arrest in fact on cardiac arrest you see a 30% decrease in the probability of having cardiac arrest from the cohort that's on the gp1 verus Bia wow schizophrenia so so this goes to the point if you guys remember the interview I did a couple months ago with the CEO of Eli Lily that they have all these

clinical trials going on right now for different indications for the glp1 receptor agonists that they're seeing that there's health benefits Beyond just the weight loss in reducing things like kidney disease obviously liver problems mental problems and so on do we know why and and if we don't know why do you think it's because this is suppressing the food and it's the the lack of food or the change in the food consumption that's creating this do you know what I'm asking like do you think the drug is actually yeah yeah so um you should watch the interview I did with RX in fact this is a good

moment to call it out if you haven't seen it yeah I think he highlights that this class of drugs there are you know genes get turned on and off so there's a you know what's called a gene expression Cascade that occurs with certain compounds so we know that the gp1 receptor Agonist means that it binds to these glp1 sites and there's a cascading effect of genes that then get expressed and what that seems to do is turn off things like inflammatory markers it turns on things like C two genes which can actually increase cellular repair so there seem to be other benefits from these drugs Beyond just the appetite

control and it's not the appetite control itself but there seems to be other effects let me ask you a question from these these receptors being activated would you put your kids on this no okay would you put your wife on this I would consider it and I would consider it for myself too just for the anti-inflammatory effects how will you make that decision well for me personally and the thing that I weigh against is the muscle loss and uh the the bone density loss so I think that if you look at the the biggest kind of effect on these on a on the downside basis is you should increase your protein in your diet you have to do weightlifting there's things that you

would do and frankly if you do those things anyway if you increase protein in your diet and do more weightlifting you're actually going to see very good health benefits from just doing those things that may actually outweigh the benefits you get from on the G I have a question D which is and this is the question is when when you look at that data and you talk to the the CEOs how much you think really longterm when the longterm sites are out is going to be that it was the drug or just that being obese is very bad for you and so when you take your body fat down dramatically all these other Gene Expressions happen anyway right so you think it which one will it be well this

is this is what they're starting to isolate and I will say Antonio they are starting to see that there are other Expressions that are not related to the Obesity and people that don't have obesity that they're using that are using these drugs so they're they're seeing that cohort data now clinical studies uh phase two were published and I think we're going to see phase three and some of these indications soon but it is looking very positive that it's not just the loss of obesity now to your point being obese not exercising eating poorly destroys your health you stop that right right everything gets better um if you lift weight freeer can you tell us when you

decide to do this I will yeah if I if I do do a glp1 um receptor Agonist I will let you guys know right now I'm I I actually feel like I want to go through a process of increasing uh my weightlifting routine more I I you know I've been trying to create a more kind of rigorous my schedule just sucks so that's been the hardest thing for me but I actually want to go through that first before making that decision kind of cool David I'm sorry no I was just curious why why that order I don't understand I want to measure the effects because I do think that if you actually get into a regular

weightlifting routine and you increase protein in your diet which is another thing I've been making a a concerted measured effort to do which is hard as a vegetarian by the way you see pretty significant uh health effects and so I'm trying to get through the process of increasing muscle composition before I make the de ision on whether or not to add G one I don't want to kind of confound the two factors you know what I did that made it super easy for me um is I got uh egg whites in a carton and I have and I have this incredible uh crunchy spicy garlic thing that everybody muku and everybody makes and everybody's crazy about just in the

mornings I'll eat whatever it is 10 ounces 12 ounces of egg whites with that spicy stuff it's delicious it's awesome and I just try to you know get that whatever 30 40 grams of protein first thing in the morning and then doing the rucking well this is is easy like you just wear a 35 lb weight vest freeberg and you walk a mile or two and you will get like my problem Jason with all of this is that every time I see something so I saw Gary Brea on the Shawn Ryan podcast recently and Shan Ryan asks him like what are a handful of things that you recommend for everybody right and he recommends mineral salt and then he recommends a methylated vitamin recommends amino acids whatever there's

a protocol then if you happen to catch a clip on X of Andrew huberman he'll have a protocol and then Brian Johnson has a protocol and the problem is all these Protocols are slightly the same but they're just different enough where it creates a huge cognitive load in a normal person like myself to your point freeberg Who's busy who's got a job who's got kids how do you decide and so I would really love something to be sort of like I don't want to say gold standard because you can't say that but that is like what's the real bank for your buck what Antonio said you know are you just better off just losing the 50 pounds and then this is why these

products are successful and I think will be continue to grow pretty dramatically Antonio is because it is pop a pill and it solves all those problems it doesn't require a cognitive load it will be in a pill format soon right I mean the pills are almost here I would be very cool actually DAV if you do this U to Jamal's point about you know people being confused if you did the every the every person's um kind of story around this journey and you documented it you know like you you did like this is my weight I did weightlifting first and I did the gop1 and you actually did like a weekly thing where you checked in and even it was 10 minutes up on X or something

where you just gave people the journey um in a way that wasn't so complicated because I think people are confused Jam me I have I have very good doctors you guys get doctors but if you don't you don't know what to do by the way that the problem for me just to give you a sense of it I had a doctor in La I had a doctor in San Francisco I would have them do their own versions of things then I would have somebody else help me compare it cost me way too much money and all that complexity did was make the quality of my healthare actually go down yeah and instead what I really wanted was just a very simple protocol that said take the metformin because it's

good for you take the vitamin D take the omega-3 fatty acids otherwise just eat this meal plan and it would help me a lot more than then I've had to Cobble it together myself because by the way when you see something like you know Gary Brea is very very articulate very smart but when I see him on the Shan Ryan podcast the first thing I do is I go and populate an Amazon cart with all the things that he said because my instinct is well I should do the right thing for myself this is a couple hundred bucks it's worth the investment but then the day after somebody else say something else you know so I'll be really you have a little OCD though jamad I've known you

for a long time you get very obsessive with died because of poor health my best friend died of poor health I feel like you you should at least do the things that are preventable have you guys seen that that post jamat did with he was like half naked in the mirror he looks great what are you talking about he looks great if if you you could look like that you you'd do it too no no no I'm talking about like when you had the glucose monitor I'm sitting with him at the poker table he's got the glucose monitor and he's taking a sip of wine he's checking the glucose he's he's having like a piece of BJ then he's checking the glucose it just like literally becomes obsessive

then with the you know then we had a i me come on that's this AI stuff this Genera you know what's so funny about this picture all these clowns all these clowns on the internet are like they don't understand that when you're 6'2 these are big legs when you're six not big when you're short King when you're short King when you're like my Chopstick I lost my chopsticks when you're 57 58 I get I get it while you guys cuz you guys are all stubby and short I don't get it this is the problem with generative AI you can tell it's a fake photo you can tell that that was generative AI because nobody has legs that thin how could you

have biceps and then legs that th doesn't make sense blushing unbelievable what a thirst trap now you guys are going to find photos of Antonio and I we're going to throw them unb listen I have have four pieces of advice for people number one get good sleep number two exercise number three diet number four meditation and if you want to do that it's very simple you get you get the calm meditation app you get the eight sleep sleep you get the fitbod for fitness and then you get neutri forut your diet those are the four things you focus on make sure you have a AA you get a good Athena assistant all of this is

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