E13: SPACsgiving Special! Vaccine news, innovation vs regulation, fixing higher ed, challenge trials
- Nov 24, 2020
- 1:21:34
- Full Episode
Follow the crew: https://twitter.com/chamath https://linktr.ee/calacanis https://twitter.com/DavidSacks https://twitter.com/friedberg
Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast
Referenced in the show: NYT Article - Politics, Science and the Remarkable Race for a Coronavirus Vaccine https://www.nytimes.com/2020/11/21/us/politics/coronavirus-vaccine.html
Show Notes: 0:00 Besties congratulate Friedberg & Chamath for taking Metromile public, Chamath explains a PIPE, Sacks & Jason express their discontent for being left out of the first bestie SPAC 10:59 More positive vaccine news, NYT article on Operation Warp Speed: did the Trump administration nail it? 21:50 How will the COVID experience impact the response to the next pandemic? Morality of challenge trials, hypocrisy of regulatory capture around gambling, drug use, pharma, etc. 35:25 Why innovation has occurred so rapidly on the Internet: Permissionless innovation & lack of regulators, regulation vs. innovation 47:07 Thoughts on ISAs & how they could disrupt overpriced higher education, Dave Chappelle's contract with Comedy Central 59:58 Trump accepts defeat (sort of), Biden's cabinet selections so far 1:06:29 What the besties are thankful for 1:14:50 Peace in the Middle East being achieved by declining reliance on oil, based on resume alone - would Trump have won if not for his antics? 1:21:01 Code 13!
Brief Summary
David Friedberg announces Metro Mile's IPO and discusses innovative insurance models and the impact of mRNA vaccines on public health.
Key points
- Metro Mile's Innovative Insurance Model. Metro Mile offers a pay-per-mile insurance model, potentially saving customers significantly.
- Operation Warp Speed's Success. The Trump administration's Warp Speed project effectively accelerated vaccine development.
- The Future of Vaccines. The approach to vaccines may have changed permanently due to mRNA technology.
- Challenge Trials in the UK. The UK is set to begin challenge trials, raising ethical questions about their execution.
- Regulatory Capture in Drug Trials. The discussion highlights how regulatory frameworks can hinder innovation in drug trials.
- The Burden of Regulation. Discussion on how regulations hinder opportunities for individuals, especially in trades.
Episode highlights
- Metro Mile's Innovative Insurance ModelMetro Mile offers a pay-per-mile insurance model, potentially saving customers significantly.“If you don't drive, you save!”2:14Nov 24, 2020
- Operation Warp Speed's SuccessThe Trump administration's Warp Speed project effectively accelerated vaccine development.“They shoveled money to the right people.”15:55Nov 24, 2020
- The Future of VaccinesThe approach to vaccines may have changed permanently due to mRNA technology.“Our approach to doing vaccines may have just changed permanently.”22:11Nov 24, 2020
- Challenge Trials in the UKThe UK is set to begin challenge trials, raising ethical questions about their execution.“In the UK, they're going to be doing the first challenge trials in January.”26:02Nov 24, 2020
- Regulatory Capture in Drug TrialsThe discussion highlights how regulatory frameworks can hinder innovation in drug trials.“Regulatory capture has driven the structure around risk taking in drug trials.”32:30Nov 24, 2020
- The Burden of RegulationDiscussion on how regulations hinder opportunities for individuals, especially in trades.“It's insane that you can't just go be a hairdresser.”45:07Nov 24, 2020
- The Value of Vocational TrainingA call to respect vocational skills over traditional degrees in American culture.“We need to celebrate vocational capability.”54:14Nov 24, 2020
- Income Sharing AgreementsExploration of ISAs as a solution for funding education without upfront costs.“The ISA as a service idea is a brilliant idea.”56:41Nov 24, 2020





